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How does the brain retrieve memories, articulate words, and focus attention? Recent advances have provided a newfound ability to decipher, sharpen, and adjust electrical signals relevant to speech, attention, memory and emotion. Join Brian Greene and leading neuroscientists György Buzsáki, Edward Chang, Michael Halassa, Michael Kahana and Helen Mayberg for a thrilling exploration of how we’re learning to read and manipulate the mind.

The Kavli Prize recognizes scientists for their seminal advances in astrophysics, nanoscience, and neuroscience — topics covered in the series “The Big, the Small, and the Complex.” This series is sponsored by The Kavli Foundation and The Norwegian Academy of Science and Letters.

Participants:
Michael Halassa.
Edward Chang.
Michael Kahana.
Helen S. Mayberg.
György Buzsáki.

Moderator:

The formula for rational thinking explained by Harvard professor Steven Pinker.

Up next, The war on rationality ► https://youtu.be/qdzNKQwkp-Y

In his explanation of Bayes’ theorem, cognitive psychologist Steven Pinker highlights how this type of reasoning can help us determine the degree of belief we assign to a claim based on available evidence.

Bayes’ theorem takes into account the prior probability of a claim, the likelihood of the evidence given the claim is true, and the commonness of the evidence regardless of the claim’s truth.

Perhaps, human consciousness can be fully understood one day.

Researchers from Johns Hopkins and Cambridge universities have created the first-ever map of the wiring patterns of every neuron in the fruit fly larval brain.

Neurons in an organism’s nervous system, including the brain, are linked to one another by synapses.


University of Cambridge.

A series of three neuroimaging studies identified a pattern of neural activation involving specific brain regions that differentiates drug users from non-users with 82% accuracy. Researchers named the pattern the Neurobiological Craving Signature (NCS). Their findings have been published in Nature Neuroscience.

Craving is a strong desire to use drugs or eat. It has long been considered a key factor driving substance abuse and overeating. It is one of the criteria used for diagnosing substance use disorders. Craving is often induced by exposure to certain stimuli. In the case of overeating, these include the smell or sight of food. In the case of drugs, craving can be induced by one being in places or situations he/she associates with taking drugs or being offered drugs. This is called cue-induced craving.

Earlier studies of craving have successfully relied on self-reported craving, but recent research has focused on discovering its biological basis. Human neuroimaging studies have identified neural circuits related to the risk of substance abuse. Some brain circuits have been found to be involved in different substance use disorders and risky behaviors. These include specific parts of the ventromedial prefrontal cortex (vmPFC), ventral striatal/nucleus accumbens (VS/NAc) and insula regions of the brain. These regions also appear to play a role in weight gain and obesity.

https://youtu.be/tiAw2gSesoM

Thank you for watching my video about Elon Musks Neuralink! If you liked it, please consider subscribing! Have a great day. #neuralink #elonmusk.

Neuralink is a neurotechnology company founded by Elon Musk in 2016 with the goal of.
merging the human brain with artificial intelligence. The company aims to develop a.
brain-machine interface that will enable humans to communicate with computers and other.
devices directly through their thoughts. Neuralink’s ultimate vision is to create a symbiotic.
relationship between humans and AI, where the brain and the computer work together to.
enhance human capabilities. While there is a huge potential in this field, it could also turn out.
to be extremely dangerous. Here’s why.

Researchers have completed the most advanced brain map to date, that of an insect, a landmark achievement in neuroscience that brings scientists closer to true understanding of the mechanism of thought.

“It’s been 50 years and this is the first brain connectome. It’s a flag in the sand that we can do this.” —

The international team led by Johns Hopkins University and the University of Cambridge produced a breathtakingly detailed diagram tracing every neural connection in the brain of a larval fruit fly, an archetypal scientific model with brains comparable to humans.

A new paper in Nature Communications illuminates how a previously poorly understood enzyme works in the cell. Many diseases are tied to chronic cellular stress, and UMBC’s Aaron T. Smith and colleagues discovered that this enzyme plays an important role in the cellular stress response. Better understanding how this enzyme functions and is controlled could lead to the discovery of new therapeutic targets for these diseases.

The enzyme is named ATE1, and it belongs to a family of enzymes called arginyl-tRNA transferases. These enzymes add arginine (an amino acid) to proteins, which often flags the proteins for destruction in the cell. Destroying proteins that are misfolded, often as a result of cellular stress, is important to prevent those proteins from wreaking havoc with cellular function. An accumulation of malfunctioning proteins can cause serious problems in the body, leading to diseases like Alzheimer’s or cancer, so being able to get rid of these proteins efficiently is key to long-term health.

The new paper demonstrates that ATE1 binds to clusters of iron and sulfur ions, and that the enzyme’s activity increases two-to three-fold when it is bound to one of these iron-sulfur clusters. What’s more, when the researchers blocked cells’ ability to produce the clusters, ATE1 activity decreased dramatically. They also found that ATE1 is highly sensitive to oxygen, which they believe relates to its role in moderating the cell’s stress response through a process known as .