Archive for the ‘neuroscience’ category: Page 385

Feb 14, 2020

Going mobile: FDA clears world’s first bedside MRI scanner-on-wheels

Posted by in categories: biotech/medical, neuroscience

The FDA has cleared the world’s first portable MRI system, designed to be wheeled to a hospital bedside for scanning a patient’s head and brain.

Developed by Hyperfine Research for people age two and older, the point-of-care imaging system weighs about one-tenth that of a conventional, fixed MRI system. About three feet wide and five feet tall, the device fits in an elevator and runs off an everyday power outlet to create both clinical contrast images and 3D renders.

“More than 40 years after its first use, MRI remains a marvel. Unfortunately, it also remains inaccessible,” Hyperfine Chief Medical Officer Khan Siddiqui said in a statement. “It’s time that MRI made the jump to point of need just like X-ray and ultrasound have before it.”

Feb 13, 2020

Scientists find ally in fight against brain tumors: Ebola

Posted by in categories: biotech/medical, neuroscience

Glioblastomas are relentless, hard-to-treat, and often lethal brain tumors. Yale scientists have enlisted a most unlikely ally in efforts to treat this form of cancer — elements of the Ebola virus.

“The irony is that one of the world’s deadliest viruses may be useful in treating one of the deadliest of brain cancers,” said Yale’s Anthony van den Pol, professor of neurosurgery, who describes the Yale efforts Feb. 12 in the Journal of Virology.

The approach takes advantage of a weakness in most cancer tumors and also of an Ebola defense against the immune system response to pathogens.

Feb 13, 2020

Grateful Dead Drummer’s Quest to End Alzheimer’s

Posted by in categories: biotech/medical, media & arts, neuroscience

Hart’s demonstrations are entertainment for sure. But his message runs deeper: rhythm and vibration heal the brain. Dementia, he says, is the “loss of rhythm.” And he, along with notables who collaborated on the event — University of California at San Francisco neuroscientist Adam Gazzaley and opera singer Renée Fleming (who lent her soprano to the event’s musical track) — are all at work searching for pathways that can bypass obstacles to function and cognition. Hart has also worked with Dr. Connie Tomaino, who runs the Institute for Music and Neurologic Function, on music as a therapeutic tool for brain function.

Gazzaley is currently conducting clinical trials with healthy older adults to show how a regular regimen of digital rhythm can enhance attention and memory in people with cognitive impairment. Hart has been working with Gazzaley on what will be a downloadable app, their goal to develop a game that challenges one’s rhythmic ability, with the hope of building new neuropathways in the brain. “What we’re talking about here is a deeper and longer immersive experience which can actually harness the brain’s plasticity to change the way it functions,” says Gazzaley.

Taking up an instrument as a child, and playing through adulthood is one proven way to protect one’s brain. But learning later in life is helpful, too. Hart shares the story of his unlikely best friend, Walter Cronkite, who was 73 when he became a Deadhead, and also started playing the drums. In July of 2009, as Cronkite lay dying from complications of cerebrovascular disease, Hart handed him a hand drum. “He could no longer speak, but he could play,” Hart says, tears in his eyes. “He used to ask, ‘When we do we know we have found our groove?’ Well, he found it.”

Feb 13, 2020

Can art be effective medicine for treatment of mental and physical illness?

Posted by in categories: biotech/medical, education, health, neuroscience

Yes! In this video with my dear friend, artist Nicholas Wilton, I review the scientific data linking creativity and disease remission from Mind Over Medicine. Plus, Nick reads the quote he wrote in Brene Brown’s Daring Greatly about art-making as treatment for perfectionism. If you or someone you love has been hoping to become a “health outlier” who experiences a better than usual outcome from a health struggle, or if you just love art and want to improve your art-making as part of your prescription for optimal health and a vital, fully expressed life, we hope this will offer you inspiration—and a few medicinal laughs! (As an OB/GYN, I couldn’t resist drawing the female reproductive systems when we got to the art-making part.)

Nick will be teaching a wonderful free online art class ART 2 LIFE that starts on Valentine’s Day, so give yourself this gift of your love of art-making. You can sign up for the free course here.

Feb 13, 2020

Childhood brain tumor discovery may unlock new treatments for many cancers

Posted by in categories: biotech/medical, neuroscience

“” This cancer seems simple. Basically, it has been known for many years it is just one type of cells that proliferate out of control,” Zong said. “However, we noticed an interesting paradox. While tumor cells grow really fast in the body, they grow poorly and only for a limited time when we take them out and put them in a [lab] dish. So we suspected some other cells may be in play.”

His investigation of that suspicion turned science’s understanding of medulloblastoma on its head. Using an innovative model of the disease, Zong and his team marked tumor cells so that they would appear green. That led to the first surprise: While all other cell types outside the tumor are colorless, a cell type called astrocyte appeared green, which never happens in normal brain regions.

“Astrocyte actually has been linked to poor prognosis of medulloblastoma, but nobody has ever suspected its origin, since the cell of origin for medulloblastoma normally never gives rise to astrocytes. The fact that tumor-associated astrocytes share the same color with tumor cells suggests that they actually come from tumor cells,” he said. “So some tumor cells basically completely change their identity to make a separate cell type.”

Continue reading “Childhood brain tumor discovery may unlock new treatments for many cancers” »

Feb 13, 2020

LifeXtenShow – Loss of Proteostasis

Posted by in categories: biotech/medical, life extension, neuroscience

On this informative episode of X10, Giuliano explains proteins and how they misfold, causing the hallmark of aging known as loss of proteostasis- which leads to Alzheimer’s disease and other dangerous diseases.

Feb 13, 2020

Molecular Switch Reverses Chronic Inflammation & Aging

Posted by in categories: biotech/medical, life extension, neuroscience

A molecular switch has been identified by scientists at the University of California that controls the immune machinery which is responsible for chronic inflammation within the body; findings published in the journal Cell Metabolism may lead to new ways to halt and/or reverse age related conditions such as cancer, diabetes, Alzheimer’s and Parkinson’s disease.

“My lab is very interested in understanding the reversibility of aging,” said senior author Danica Chen, associate professor of metabolic biology, nutritional sciences and toxicology at UC Berkeley. “In the past, we showed that aged stem cells can be rejuvenated. Now, we are asking: to what extent can aging be reversed? And we are doing that by looking at physiological conditions, like inflammation and insulin resistance, that have been associated with aging-related degeneration and diseases.”

A bulky collection of NLRP3 inflammasome immune proteins which are responsible for sensing potential threats to the body and launching an inflammatory response were shown to be essentially switched off by removing some molecular matter in a deacetylation process. Overactivation of NLRP3 inflammasomes is linked to a range of chronic conditions such as cancer, dementia, diabetes, and multiple sclerosis; this study suggests that drugs targeted towards deacetylation these NLRP3 inflammasomes may help to prevent and/or treat many age related conditions and even possibly age related degeneration itself in general.

Feb 13, 2020

The brain compresses data like an MP3

Posted by in category: neuroscience

Granule cells improve the storage capacity of the brain using the same trick that is used to compress digital audio files into an MP3.

Feb 13, 2020

Interventions for pain: Finding connections at the surface

Posted by in categories: biotech/medical, health, nanotechnology, neuroscience

Like buoys bobbing on the ocean, many receptors float on the surface of a cell’s membrane with a part sticking above the water and another underwater, inside the cell’s cytoplasm. But for cells to function, these receptors must be docked at specific regions of the cell. Most research has focused on the ‘underwater’ portions. That’s where the cell’s molecular machines swarm and interact with a receptor’s underwater tails, with those interactions then fueling signals that dive deep into the nucleus, changing the cell’s course.

New work by a team of Thomas Jefferson University researchers reveals new activity above the surface, in brain-cell receptors that govern learning and chronic pain. In the study, the authors show that the ‘above water’ portion of proteins can help dock the proteins at synapses, where neurons mediate flow of information throughout the brain. This discovery opens the possibility of using this docking site as a target to develop treatments for chronic pain and other diseases more effectively. The study was published January 29th in Nature Communications.

“The extracellular spaces — the parts ‘above the water’ — have been largely overlooked,” says senior author Matthew Dalva, PhD, professor and vice chair of the Department of Neuroscience and director of the Jefferson Synaptic Biology Center in the Vickie & Jack Institute for Neuroscience — Jefferson Health. Dr. Dalva and his team looked at the NMDAR receptor on brain cells and pinpointed the spot where this receptor interacts with a neighbor to initiate signaling. “When trying to develop new therapy, finding the bullseye is half the problem,” says Dr. Dalva.

Feb 13, 2020

Neuroprosthetics: Medicine of the future

Posted by in categories: biotech/medical, cyborgs, life extension, neuroscience

Neuroprosthesis is the process of using direct electric stimulation to enable proper functioning of the nervous system. Neuroprosthetic devices supplements the input or the output signals to the neural system, enabling the individual to carry out proper functioning and physical activities. Some of the purposes which involve the use of neuroprosthetics include, techniques for bladder and bowel control, deep brain stimulation, and restoration of mobility and respiration to paralyzed individuals.

Get PDF sample copy of study @

Brain disorders exhibits a considerable social and economic burden in Europe. According to WHO survey, brain disorders are responsible for 35% of Europe’s total disease burden. This burden is increasing due to increasing number of aging population in Europe, and requires a considerable attention to address the treatment issues as all the cases does not respond to medication therapy.