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Category: neuroscience – Page 21

Neighborly help in the brain: Cerebral cortex networks rapidly reorganize to compensate for lost neurons

How the brain largely maintains its function when neurons are lost—this is what researchers at the University Medical Center Mainz, the Frankfurt Institute for Advanced Studies (FIAS) and Hebrew University (Jerusalem) have deciphered. They show that neuronal networks in the cerebral cortex reorganize within a short period of time, with other nerve cells taking over the tasks of the lost neurons.

These findings could form the basis for future research into natural aging processes and neurodegenerative diseases such as Alzheimer’s or Parkinson’s. The study is published in the journal Nature Neuroscience.

Nerve cells (neurons) are the most important building blocks of the brain. They form the basis for all mental and physical functions such as thinking, feeling, movement, and perception. In the course of life, in the brain can be lost for various reasons: They die off due to age-related processes, are damaged by toxins such as alcohol, or neurodegenerative diseases such as Alzheimer’s and Parkinson’s lead to a more rapid progressive loss of neurons.

New imaging method reveals how lithium-metal batteries lose capacity over time

Lithium-metal batteries have not hit the market yet, but if they do, they could be a solution to the everyday woes of the dwindling battery meter. They are cousins of the lithium-ion batteries found in legions of everyday electronic devices, but with the potential to hold twice as much power. Unfortunately, the lithium-metal battery’s limited number of recharges has been a major obstacle to their wide adoption.

A new study led by researchers at the California NanoSystems Institute at UCLA, or CNSI, however, might just help ratchet up the pace of progress. In the journal Science Advances, the team documented an they invented that—for the first time ever—captures a lithium-metal battery as it charges, at a level of detail smaller than the wavelength of light.

The method, electrified , or eCryoEM for short, yielded insights that may help guide the design of better lithium-metal batteries. Cultivating this progress with U.S.-based research could give the U.S. an edge in this successor technology to , an industry currently dominated by Chinese enterprises. The study also holds promise for shedding light on mysteries in disciplines as far afield as neuroscience.

Different genetic roots of autism may lead to shared brain activity and behaviors

New research from the University of Minnesota Medical School suggests that different genetic forms of autism may lead to similar patterns in brain activity and behavior. The findings were recently published in Nature Neuroscience.

Using brain-recording technology, the research team observed neurons across the entire brain to explore whether different genetic forms of autism share patterns and establish commonalities in neural responses. They found that, despite , various forms may show a similar unique pattern of —also known as a brain signature.

“We hope this research will serve as a stepping stone linking genetic differences and behavioral atypicalities,” said Jean-Paul Noel, Ph.D., an assistant professor at the University of Minnesota Medical School.

Common sleep aid blocks brain inflammation and tau buildup in Alzheimer’s model

Scientists have found that lemborexant not only increased restorative sleep in male mice but also reduced levels of toxic tau and brain inflammation. The findings suggest that targeting the brain’s orexin system may help slow Alzheimer’s progression.

Repurposed cancer drugs shown to promote stroke recovery and limit brain damage

Stroke remains one of the leading causes of death, disability, increased economic burden and decreased quality of life around the world. Current stroke therapies are time-limited and largely focused on restoring blood flow, and there are few which address the secondary wave of inflammation that causes further injury in the hours and days after stroke.

A study by researchers from the Yong Loo Lin School of Medicine, National University of Singapore (NUS Medicine), has shown that a class of drugs, HDACi (), protects neurons and limits following stroke by altering the gene expression of microglia, the immune cells of the brain.

HDACi are currently used or being tested as treatments for certain cancers and are also being researched for neurological conditions such as Alzheimer’s disease.

Photon transport through the entire adult human head

SignificanceThe highly scattering nature of near-infrared light in human tissue makes it challenging to collect photons using source-detector separations larger than several centimeters. The limits of detectability of light transmitted through the head remain unknown. Detecting photons in the extreme case through an entire adult head explores the limits of photon transport in the brain. AimWe explore the physical limits of photon transport in the head in the extreme case wherein the source and detector are diametrically opposite. ApproachSimulations uncover possible migration pathways of photons from source to detector. We compare simulations with time-resolved photon counting experiments that measure pulsed light transmitted through the head. ResultsWe observe good agreement between the peak delay time and width of the time-correlated histograms in experiments and simulations. Analysis of the photon migration pathways indicates sensitivity to regions of the brain well beyond accepted limits. Source repositioning can isolate sensitivity to targeted regions of the brain, including under the cerebrum. ConclusionsWe overcome attenuation of ∼1018 and detect photons transmitted through an entire adult human head for a subject with fair skin and no hair. Photons measured in this regime explore regions of the brain currently inaccessible with noninvasive optical brain imaging.