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Physicist: I Believe You Can Enhance Your Consciousness—And Expand Your Perception Into a “Different Realm”

But what if our biological makeup limits how creative we can be? Maybe the timing of the clock that governs our introspections forces our intuitive periods—or the times of uncertainty—to be too brief. Could we use our quantum technologies to extend the wavelike processing inside our brains? I am here inspired by Aldous Huxley, who suggested in his famous book, The Doors of Perception, that drugs could alter our consciousness, revealing true reality. But rather than using drugs, I envision quantum chips designed to suppress the “noise” that induces introspection, allowing a longer interference period for our intuitive thoughts to develop. This has the potential to be far more potent than what Huxley could ever have imagined.

For my idea to work, we would first have to understand where and how these superpositions are stored and manipulated in the brain. The British physicist Roger Penrose, PhD, has speculated that this occurs within microtubules, which are dynamic, hollow, rod-like components of the eukaryotic cytoskeleton that are responsible for things such as intercellular transport. Despite some circumstantial evidence, we do not have a strong reason to believe that microtubules are capable of quantum interference, but they are certainly worth further investigation. Once we understand how our brain uses quantum effects, we could then design a quantum chip that interfaces with the relevant biological components. Theoretically, the device would be able to upload superposition states to store them for longer periods and shield them from collapse, helping us to enhance our creative wavelike thinking.

One wonders what kind of power would be unleashed by doing this. I imagine the change would not be purely quantitative, so that we merely become faster calculators or quicker problem solvers, although even that would be amazing. Instead, I think the change could be qualitative, expanding our perception into a completely different realm, effectively creating a new species. We might theoretically become more powerful than modern humans, just as we currently are with respect to other apes. Quantum-enhanced humans would see further domains of reality that would otherwise remain hidden forever from us ordinary humans.

Identifying Key Regulators in Odorant Receptor Trafficking

JNeurosci: Lu and Matsunami analyzed gene activity to find proteins that help odor-detecting receptors reach the cell surface. They identified three helper genes—Gfy, Clgn, and Syt1—that support receptor function as olfactory cells mature.

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Odor detection in mammals is primarily mediated by odorant receptors (ORs), the largest family of G-protein-coupled receptors, expressed in olfactory sensory neurons (OSNs; [Buck and Axel, 1991][1]). However, most ORs exhibit little or no cell surface expression in nonolfactory cell types ([Lu et al., 2003][2]; [Hague et al., 2004][3]). While the accessory protein RTP1 and RTP2 enhance the expression of certain ORs, we hypothesized that additional proteins coregulated with RTP1 and RTP2 during OSN maturation may further enhance OR cell surface expression ([Saito et al., 2004][4]; [Zhuang and Matsunami, 2007][5]). To test this, we developed a computational pipeline based on publicly available single-cell transcriptomic data to create an interactive tool for exploring gene expression during OSN maturation.

One-question screen may flag hoarding in Alzheimer’s and other dementias

Researchers at the University of Colorado Anschutz have developed a simple, one-question screening tool that could help doctors quickly identify hoarding behaviors in patients with memory loss and other brain disorders. Early detection, they said, could lead to early intervention, helping to reduce safety risks, relieve caregiver stress and improve the quality of life for both patients and families.

The new tool was examined in a study published this month in The Journal of Neuropsychiatry and Clinical Neurosciences. The study was co-led by Peter Pressman, MD and Julia Schaffer, BA. The senior author is David Arciniegas, MD, professor of neurology at CU Anschutz.

“This was really born of shared observations in the memory clinic,” said Pressman, associate professor of neurology at Oregon Health & Science University who conducted the research while at CU Anschutz. “We noticed that hoarding was very common in these patients but it was not part of any screening protocols.”

Engineered protein markers read living brain gene activity in monkeys via blood

Gene therapy has been successfully used to treat a number of diseases, including immune deficiencies, hereditary blindness, hemophilia and, recently, Huntington’s disease, a fatal neurological disorder.

An advance reported in the journal Neuron adds to the technique’s growing track record of evidence supporting the view that it could unlock powerful, personalized therapies: Rice University bioengineer Jerzy Szablowski and collaborators in Vincent Costa’s lab at Emory University found that released markers of activity (RMAs) — engineered proteins designed to cross the blood-brain barrier and persist in the blood for hours at a time, providing a reliable and noninvasive way to get information about gene expression in the brain — work just as well in monkeys as they do in mice.

On the route from laboratory discovery to lifesaving treatment, large animal model studies are a critical part of the process. Most research never reaches this stage.

Bioengineered neuronal ‘circuit board’ mimics conditions of the human brain

A new bioengineered neuronal circuit board “BioConNet” allows scientists to artificially engineer human brain-like wiring at scale and can be used to engineer any possible circuit. The fully programmable, open-source system allows generation of large-scale circuits, while maintaining the ability to focus on single connections between neurons.

This is a key advance in engineering human-like neural circuits as it allows for a new level of wiring complexity compared to previous systems. BioConNet allows scientists increased control over wiring in the culture compared to existing methods such as organoids and commercially available systems. The research is published in the journal Advanced Healthcare Materials.

“By combining engineering and neurobiology with the most recent stem cell culture techniques, we can now create human-specific, functional, large-scale complex neural circuits in the lab,” said senior author, Dr. Andrea Serio, Reader in Neural Tissue Engineering, Group Leader at the UK Dementia Research Institute (UK DRI) at King’s and Senior Group Leader at the Crick.

High-Pressure Freezing EM Tomography of Entire Ribbon Synapses in the Retina

JNeurosci: Using advanced electron microscopy in rats, Zhang et al. captured 3D images of chemical synapses that perform visual computations in the retina. Their findings reveal how neural connections are structured for efficient visual signaling.

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In the retina, presynaptic active zones in photoreceptors and bipolar cells are distinguished by a plate-like “ribbon” linked to the plasma membrane (PM) and surrounded by dozens of synaptic vesicles (SVs) tethered to it. SVs at the base of the ribbon, closest to the PM, are thought to constitute the readily releasable vesicle pool (RRP), i.e., SVs primed to be released 1–2 ms following stimulation. The number of SVs in the RRP is a critical synaptic parameter that influences synaptic strength and varies with light levels to enable ribbon synapses to compute visual information. Physiological RRP measurements agree well with anatomical estimates obtained via electron microscopy (EM), although EM often employs chemical fixation, which causes exocytotic artifacts that may influence RRP size.

Adherence to Different Dietary Patterns and Subsequent Risk of Total, Ischemic, and Hemorrhagic Stroke

In people with elevated cardiovascular risk at baseline, adherence to the Mediterranean and Mediterranean-DASH Diet Intervention for Neurodegenerative Delay diets was associated with a lower risk of stroke.


BACKGROUND: Adherence to healthy dietary patterns has been related to lower cardiovascular disease risk. However, few studies have examined prospective associations between adherence to different healthy dietary scores and the incidence of stroke and its subtypes. The aim of this study was to prospectively examine the associations between adherence to 4 recognized healthy dietary patterns and the risk of total and ischemic stroke in an existing dietary-based randomized controlled trial. METHODS: This is a secondary observational cohort analysis of 7,447 participants at high cardiovascular disease risk enrolled in the PREDIMED trial (Prevención Con Dieta Mediterranea).

What Can 50-Year-Old Chatbots Teach Us About Clinical Applications of AI?

Can a large language model (LLM) provide insights on the history of chatbots and their clinical applications? 🤖

In this episode of JAMA+ AI Conversations, JAMA+ AI Editor in Chief Roy Perlis, MD, MSc, interviews OpenAI’s ChatGPT (GPT-4o, voice mode) about the development and legacy of the first clinical chatbots, ELIZA and PARRY.

The discussion explores differing perspectives of their creators, as well as how foundational debates about technology and ethics continue to inform the present landscape of AI in mental health care.

🎧 Listen now.


JAMA+ AI Editor in Chief Roy Perlis, MD, MSc, conducted an interview with ChatGPT about the history of chatbots and their clinical applications, for JAMA+ AI Conversations.

Living ‘Mini Brains’ Meet Next-Generation Bioelectronics

A team led by Northwestern University and Shirley Ryan AbilityLab scientists have developed a new technology that can eavesdrop on the hidden electrical dialogues unfolding inside miniature, lab-grown human brain-like tissues, according to a study published the journal Nature Biomedical Engineering.

Known as human neural organoids — and sometimes called “mini brains” — these millimeter-sized structures are powerful models of brain development and disease. But until now, scientists could only record and stimulate activity from a small fraction of their neurons — missing network-wide dynamics that give rise to coordinated rhythms, information processing and the complex patterns of activity that define brain function.

For the first time, the new technology overcomes that stubborn limitation. The soft, three-dimensional (3D) electronic framework wraps around an organoid like a breathable, high-tech mesh. Rather than sampling select regions, it delivers near-complete, shape-conforming coverage with hundreds of miniaturized electrodes. That dense, three-dimensional interfacing enables scientists to map and manipulate neural activity across almost the entire organoid.

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