Posted in neuroscience | Leave a Comment on Nasal anti-CD3 monoclonal antibody ameliorates traumatic brain injury, enhances microglial phagocytosis and reduces neuroinflammation via IL-10-dependent Treg–microglia crosstalk Neuroscience
Nasal anti-CD3 therapy shows promise for treating traumatic brain injury by reducing neuroinflammation and aiding recovery in mice. It induces interleukin-10-producing regulatory T cells that enhance microglial phagocytic activity and reduce chronic inflammation, potentially aiding brain repair.
Could your driving habits reveal your mental health? Research shows AI can analyze driving data to identify depression risk in older adults.
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Biomedical engineers at the University of Melbourne have developed a 3D bioprinting system capable of creating structures that closely replicate various human tissues, ranging from soft brain tissue to more rigid materials like cartilage and bone.
This innovative technology provides cancer researchers with a powerful tool for replicating specific organs and tissues, enhancing their ability to predict drug responses and develop new treatments. By offering a more accurate and ethical approach to drug discovery, it also has the potential to reduce reliance on animal testing.
Head of the Collins BioMicrosystems Laboratory at the University of Melbourne, Associate Professor David Collins said: In addition to drastically improving print speed, our approach enables a degree of cell positioning within printed tissues. Incorrect cell positioning is a big reason most 3D bioprinters fail to produce structures that accurately represent human tissue.
New data on brain-wide circuits centred around two interconnected hypothalamic neuron populations provide significant mechanistic insights into the emergence of social need during social isolation and the satiation of social need during social reunion.
Scientists at the La Jolla Institute for Immunology (LJI) have identified a potential new target for Parkinson’s disease treatment. Their research highlights the role of a specific brain cell protein in triggering the disease and may explain why Parkinson’s is more prevalent in men.
Recent studies from LJI suggest that autoimmunity plays a key role in Parkinson’s onset. Their latest findings, published in The Journal of Clinical Investigation, reveal that the protein PINK1 may label certain brain cells for attack by the immune system, contributing to disease progression.
“This research allows us to better understand the role of the immune system in Parkinson’s disease,” says LJI Professor Alessandro Sette, Dr. Biol. Sci., senior author of the recent study.
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Summary: A new study challenges the long-held belief that the striatum is responsible for selecting actions. Researchers found that instead of making decisions, the striatum and motor cortex work together to specify movement details, such as how to reach for an object.
Using a novel “reach-to-pull” system, they recorded neural activity in mice and found that both regions were active during movement execution, not decision-making. These findings could reshape our understanding of motor control and help improve treatments for movement disorders like Parkinson’s and Huntington’s disease.
Slides here: http://bit.ly/MZMmdp — Whole Brain Emulation & Computational Neuroscience Synopsis Within a few decades, I believe it will be possible to construct working simulations of an entire human brain. In this talk I will explain why I believe this, with reference to recent work in Computational Neuroscience, extrapolations of Moore’s Law, and other such matters. I will also address some common criticisms leveled against whole brain emulation, and briefly discuss some of the many ways I believe this technology will drastically change the face of society in the near future.
I’ll basically be presenting selected material from this publication, with some updates and additions of my own.
http://www.fhi.ox.ac.uk/brain-emulation-roadmap-report.pdf.
Science, Technology & the Future — By Design.
Summary: Scientists have developed e-Taste, a novel technology that digitally replicates taste in virtual environments. Using chemical sensors and wireless dispensers, the system captures and transmits taste data remotely, enabling users to experience sweet, sour, salty, bitter, and umami flavors.
In tests, participants distinguished different taste intensities with 70% accuracy, and remote tasting was successfully initiated across long distances. Beyond gaming and immersive experiences, this breakthrough could enhance accessibility for individuals with sensory impairments and deepen our understanding of how the brain processes taste.
