Archive for the ‘neuroscience’ category: Page 19

Aug 27, 2020

Study leads to potential for new treatment approach to Alzheimer’s

Posted by in categories: biotech/medical, genetics, life extension, neuroscience

Research looking at a possible new therapeutic approach for Alzheimer’s disease was recently published in the Journal of Neuroinflammation. The paper out of the University of Kentucky’s Sanders-Brown Center on Aging (SBCoA) is titled “Therapeutic Trem2 activation ameliorates amyloid-beta deposition and improves cognition in the 5XFAD model of amyloid deposition”. The work looked at targeting inflammation by using an antibody. Alzheimer’s disease and related dementias have no disease-modifying treatments at this time and represent a looming public health crisis given the continually growing aging population.

The paper explains that current therapeutic approaches to the treatment of Alzheimer’s focus on the major pathological hallmarks of the disease which are and neurofibrillary tangles. They are the requirements for a diagnosis of Alzheimer’s disease. However, the authors say there has been an explosion of genetic data suggesting the risk for sporadic Alzheimer’s disease is driven by several other factors including neuroinflammation, membrane turnover and storage, and .

In this study the researchers focused on triggering receptor expressed on myeloid cell-2 (TREM2). “TREM2 was identified several years ago as a gene that, when there’s a mutation, significantly increases risk of Alzheimer’s disease. The field thinks that this mutation reduces the function of the receptor, so we hypothesized that targeting TREM2 to increase its function might be a valid treatment for Alzheimer’s,” explained Donna Wilcock, SBCoA associate director.

Aug 27, 2020

The US military is trying to read minds

Posted by in categories: 3D printing, biotech/medical, computing, Elon Musk, military, neuroscience

Elon Musk’s Neuralink will likely show off its design for a brain-computer interface Friday evening. The concept it unveiled last summer involves surgically implanting it into the brain to detect the activity of neurons. The US military also wants to develop a brain-computer interface, as we explain in this story from October. But here’s the kicker: no surgery required—and the device could be put on and taken off like a helmet or headband.

In August, three graduate students at Carnegie Mellon University were crammed together in a small, windowless basement lab, using a jury-rigged 3D printer frame to zap a slice of mouse brain with electricity.

The brain fragment, cut from the hippocampus, looked like a piece of thinly sliced garlic. It rested on a platform near the center of the contraption. A narrow tube bathed the slice in a solution of salt, glucose, and amino acids. This kept it alive, after a fashion: neurons in the slice continued to fire, allowing the experimenters to gather data. An array of electrodes beneath the slice delivered the electric zaps, while a syringe-like metal probe measured how the neurons reacted. Bright LED lamps illuminated the dish. The setup, to use the lab members’ lingo, was kind of hacky.

Continue reading “The US military is trying to read minds” »

Aug 26, 2020

Unlocking the Mysteries of the Brain

Posted by in category: neuroscience

Summary: Researchers have made an important discovery about the mechanisms behind learning and memory. Depending on the number of synapses, and their proximity, information is processed and stored differently.

Source: University of Montreal

How does our brain store information?

Aug 26, 2020

Neuralink event: what to know about Elon Musk’s highly-anticipated reveal

Posted by in categories: computing, Elon Musk, neuroscience

NEURALINK, ELON MUSK’S HUMAN-BRAIN LINKUP FIRM, WILL HOLD AN EVENT THIS WEEK – and it’s expected to feature a demonstration of the brain’s neurons firing in real-time.

The secretive firm has been relatively quiet since its first public event in July 2019, when Musk and his team explained how the firm plans to use chips to link human brains up to computers. In July 2020, Musk revealed that the company was planning a second event for Friday, August 28. He also reiterated the company’s mission statement: “If you can’t beat ‘em, join ‘em.”

Neuralink is set to hold its next event this week. Here’s what you need to know about the human-brain linkup firm’s plans.

Continue reading “Neuralink event: what to know about Elon Musk’s highly-anticipated reveal” »

Aug 26, 2020

When Host Diets Are Lacking, Gut Bacteria Pull Together To Survive

Posted by in category: neuroscience

To study how the microbiome affects their host behavior, a group of researchers at the Champalimaud Centre used the fruit fly combined with high-tech tools to show that two gut bacteria establish a metabolic cross-feeding that enables them to grow in diets that lack the nutrients that are essential for their growth and to allow them to change host decision making and reproduction. Results reveal a mechanism through which the right combination of bacteria can lead to microbiome resiliency to dietary perturbations and changes in brain function.

New research reveals a mechanism through which the right combination of bacteria can lead to microbiome resiliency to dietary perturbations.

Continue reading “When Host Diets Are Lacking, Gut Bacteria Pull Together To Survive” »

Aug 25, 2020

Dementia Kills Nearly Three Times More People Than Previously Thought

Posted by in categories: biotech/medical, health, neuroscience

Summary: An estimated 13.6% of deaths in the U.S could be attributed to dementia. The number is 2.7 times higher than the official reported dementia-related deaths. The underestimation varies greatly by race, with 7.1 times more older Black adults, and 4.1 times more Hispanic adults, dying from dementia that public records indicate.

Source: boston university school of medicine.

Dementia may be an underlying cause of nearly three times more deaths in the U.S. than official records show, according to a new Boston University School of Public Health (BUSPH) study.

Aug 25, 2020

Faulty Brain Circuits Arise From Abnormal Fusion

Posted by in categories: biotech/medical, neuroscience

Summary: Discovery reveals neurons can lose their individuality in some conditions. The findings contradict the conventional belief that neurons always stay separated and never fuse.

Source: University of Queensland

A discovery that could rewrite the textbooks on neurons could also help us understand the basis of some neurological diseases.

Aug 24, 2020

Genetic Variants May Explain High Levels of Antibodies Against Epstein-Barr Virus in MS, Study Suggests

Posted by in categories: biotech/medical, genetics, neuroscience

Genetic variants may contribute to increased levels of antibodies against proteins of the Epstein-Barr virus — a known environmental risk factor for multiple sclerosis (MS) — in MS patients and their siblings, a study suggests.

The study, “EBNA-1 titer gradient in families with multiple sclerosis indicates a genetic contribution,” was published in the journal Neurology, Neuroimmunology and Neuroinflammation.

Aug 24, 2020


Posted by in categories: neuroscience, transhumanism

The belief or theory that the human race can evolve beyond its current physical and mental limitations,…

Aug 24, 2020

Elon Musk to unveil Neuralink progress with real-time neuron demonstration this week

Posted by in categories: Elon Musk, neuroscience

Elon Musk’s brain-machine interface company, Neuralink, has an event scheduled for later this week to update the public on its progress since last year’s presentation. While the agenda is speculative for the most part, one expectation is a live demonstration of neuron activity.

“Will show neurons firing in real-time on August 28th. The matrix in the matrix,” Musk tweeted at the end of July.

He also revealed a few other clues about the early fall announcement at the beginning of the year. “Wait until you see the next version vs what was presented last year. It’s *awesome*,” he wrote in February. “The profound impact of high bandwidth, high precision neural interfaces is underappreciated. Neuralink may have this in a human as soon as this year. Just needs to be unequivocally better than Utah Array, which is already in some humans & has severe drawbacks.”

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