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Category: neuroscience – Page 24

This diet can protect your brain even if started later in life, study suggests

People who follow a MIND diet, even if started later in life, were significantly less likely to develop Alzheimer’s disease or related forms of dementia, according to new research.

The MIND diet stands for “Mediterranean-DASH Intervention for Neurodegenerative Delay” and combines many elements of the Mediterranean diet and DASH (“Dietary Approaches to Stop Hypertension”). It emphasizes brain-healthy foods like leafy greens, berries, nuts and olive oil.

The study, being presented Monday at the American Society for Nutrition’s annual meeting, analyzed data from nearly 93,000 U.S. adults aged 45 to 75 starting in the 1990s.

MRI method maps blood flows in reverse for deeper insight into brain physiology

The venous system maintains the health of our brains by removing deoxygenated blood and other waste products, but its complexity and variability have made scientific study difficult. Now, a UC Berkeley-led team of researchers has developed an innovative MRI technique that may expand our understanding of this critical system.

In a study published in Nature Communications, the researchers demonstrate how their new imaging method, Displacement Spectrum (DiSpect) MRI, maps blood flows “in reverse” to reveal the source of blood in the ’s veins. This approach could help answer long-standing questions about brain physiology as well as provide a safer, more efficient way to diagnose disease.

Like some current MRI methods, DiSpect uses the water in our blood as a tracing agent to map perfusion, or blood flow, in the brain. The water’s hydrogen atoms possess a quantum mechanical property called spin and can be magnetized when exposed to a magnetic field, like an MRI scanner. But what makes DiSpect unique is its ability to track the “memory” of these nuclear spins, allowing it to map blood flow back to its source.

Brain training game offers new hope for drug-free pain management

A trial of an interactive game that trains people to alter their brain waves has shown promise as a treatment for nerve pain—offering hope for a new generation of drug-free treatments.

The PainWaive technology, developed by UNSW Sydney researchers, teaches users how to regulate abnormal brain activity linked to chronic nerve , offering a potential in-home, noninvasive alternative to opioids.

A recent trial of the technology, led by Professor Sylvia Gustin and Dr. Negin Hesam-Shariati from UNSW Sydney’s NeuroRecovery Research Hub, has delivered promising results, published in the Journal of Pain.

Promising breakthroughs in amyotrophic lateral sclerosis treatment through nanotechnology’s unexplored frontier

This review explores the transformative potential of nanotechnology in the treatment and diagnosis of amyotrophic lateral sclerosis (ALS), a progressive neurodegenerative disorder characterized by motor neuron degeneration, muscle weakness, and eventual paralysis. Nanotechnology offers innovative solutions across various domains, including targeted drug delivery, neuroprotection, gene therapy and editing, biomarker detection, advanced imaging techniques, and tissue engineering. By enhancing the precision and efficacy of therapeutic interventions, nanotechnology facilitates key advancements such as crossing the blood-brain barrier, targeting specific cell types, achieving sustained therapeutic release, and enabling combination therapies tailored to the complex pathophysiology of ALS.

Neurosteroids identified as potential therapy for treatment-resistant depression

Depression, characterized by persistent sadness, hopelessness and a lack of interest in previously enjoyed activities, is one of the most common mental health disorders. Recent estimates by the World Health Organization (WHO) suggest that approximately 5% of the global population suffers from depression.

For decades, researchers have been trying to devise safe and effective treatments for that cause minimal or no side effects. This led to the introduction of a wide range of strategies, ranging from psychotherapy and to a wide range of pharmacological drugs, including (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants (TCAs), monoamine oxidase inhibitors (MAOIs) and atypical antidepressants.

Most people diagnosed with depression eventually find a suitable treatment for them via a trial-and-error process, ultimately leading to their recovery. Some individuals, however, can experience for prolonged periods of time, finding that no treatment ultimately eases their symptoms.

Fixing the leak: Blocking an opioid receptor for safer treatment of dopamine-related disorders

Dopamine, a small molecule derived from the amino acid tyrosine, plays a significant role in regulating multiple essential brain functions, including movement, mood and motivation as well as multiple cognitive functions, including attention and memory.

Dopamine signaling in the brain is a complex process, with many mechanisms in place to accelerate or slow down dopamine’s effects. When dopamine is released from nerve cells, its efficient removal to limit signaling occurs through the activity of special proteins called “transporters,” ensuring a shorter action of dopamine in the brain.

Disruptions in have been linked to several , including ADHD, schizophrenia, , , and addiction.