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Scientists develop rapid, cell-free platform for assembling Nipah virus vaccine prototypes

Researchers from Cornell and Northwestern universities have developed a rapid, cell-free method for building nanoparticle vaccines that mimic viruses at the molecular level, offering a powerful new tool for responding to emerging pandemics.

By producing and folding full-length viral membrane proteins directly into synthetic lipid bubbles called liposomes, the technique creates in hours, rather than weeks or months, and could pave the way for faster, more adaptable immunization strategies against deadly viruses like Nipah.

The research, presented in the paper “Cell-Free Expression of Nipah Virus Transmembrane Proteins for Proteoliposome Vaccine Design,” was published in the journal ACS Nano.

Self-powered solar panels remove dust using wind-generated electricity

A collaborative research team has successfully developed a self-powered pollution prevention technology that can remove pollutants from the surface of solar panels without external power. This technology uses a wind-powered rotational triboelectric nanogenerator to generate power and combines said power with electrodynamic screen (EDS) technology to move dust in the desired direction for removal.

The findings are published in the journal Nano Energy. The team was led by Professor Juhyuck Lee from the Department of Energy Science and Engineering, Daegu Gyeongbuk Institute of Science & Technology, along with Dr. Wanchul Seung at Global Technology Research, Samsung Electronics.

The dust that gathers on the surface of solar panels causes a significant reduction in power production efficiency. EDS technology, designed to address this problem, uses electric fields to remove dust from the surface, and it is noted for environments that are not easily accessible, such as deserts, mountains, and space, as it does not require cleaning equipment or personnel. Traditional EDS technology, however, requires and, consequently, external power, and it has the disadvantage of additional maintenance costs.

Scientists twist DNA into self-building nanostructures that could transform technology

Scientists have used DNA's self-assembling properties to engineer intricate moiré superlattices at the nanometer scale—structures that twist and layer like never before. With clever molecular “blueprints,” they’ve created customizable lattices featuring patterns such as honeycombs and squares, all with remarkable precision. These new architectures are more than just scientific art—they open doors to revolutionizing how we control light, sound, electrons, and even spin in next-gen materials.

Molecular Decrowding by Tissue Expansion Allows Precise Determination of the Spatial Distribution of Synaptic Proteins at a Nanometer Scale by exTEM

To understand how the molecular machinery of synapses works, it is essential to determine an inventory of synaptic proteins at a subsynaptic resolution. Nevertheless, synaptic proteins are difficult to localize because of the low expression levels and limited access to immunostaining epitopes. Here, we report on the exTEM (epitope-exposed by expansion-transmission electron microscopy) method that enables the imaging of synaptic proteins in situ. This method combines TEM with nanoscale resolution and expandable tissue-hydrogel hybrids for enhanced immunolabeling with better epitope accessibility via molecular decrowding, allowing successful probing of the distribution of various synapse-organizing proteins. We propose that exTEM can be employed for studying the mechanisms underlying the regulation of synaptic architecture and function by providing nanoscale molecular distribution of synaptic proteins in situ. We also envision that exTEM is widely applicable for investigating protein nanostructures located in densely packed environments by immunostaining of commercially available antibodies at nanometer resolution.

Expanding the material design space at the nanoscale

Researchers are creating new moiré materials at the nanometer scale using advanced DNA nanotechnology. DNA moiré superlattices form when two periodic DNA lattices are overlaid with a slight rotational twist or positional offset. This creates a new, larger interference pattern with completely different physical properties.

New AI tool deciphers mysteries of nanoparticle motion in liquid environments

Nanoparticles—the tiniest building blocks of our world—are constantly in motion, bouncing, shifting, and drifting in unpredictable paths shaped by invisible forces and random environmental fluctuations.

Better understanding their movements is key to developing better medicines, materials, and sensors. But observing and interpreting their motion at the atomic scale has presented scientists with major challenges.

Researchers in Georgia Tech’s School of Chemical and Biomolecular Engineering (ChBE) have developed an (AI) model that learns the underlying physics governing those movements.

Heterometallic nanosheets containing multiple metal ions achievable through new technique

Coordination nanosheets are a unique class of two-dimensional (2D) materials that are formed by coordination bonds between planar organic ligands and metal ions. These 2D nanomaterials are increasingly utilized in energy storage, electronic devices, and as electrode-based catalysts due to their excellent electronic, optical, redox properties, and catalytic activity.

Over the last decade, coordination nanosheets composed of various transition , such as nickel (Ni) ions linked to benzenehexathiol (BHT)—an organic compound—have been successfully synthesized in laboratories. However, their production has relied on a two-phase interfacial reaction that occurs between two immiscible phases of matter.

Furthermore, the selective synthesis of well-organized heterometallic nanosheets, containing two or more metal ions, has proven to be difficult. To address these two major issues limiting the production of novel coordination nanosheets, a team of researchers led by Professor Hiroshi Nishihara, from the Research Institute for Science and Technology (RIST), Tokyo University of Science (TUS), Japan, has conducted a series of innovative experiments.

Need a new 3D material? Build it with DNA

When the Empire State Building was constructed, its 102 stories rose above midtown one piece at a time, with each individual element combining to become, for 40 years, the world’s tallest building. Uptown at Columbia, Oleg Gang and his chemical engineering lab aren’t building Art Deco architecture; their landmarks are incredibly small devices built from nanoscopic building blocks that arrange themselves.

“We can now build the complexly prescribed 3D organizations from self-assembled nanocomponents, a kind of nanoscale version of the Empire State Building,” said Gang, professor of chemical engineering and of applied physics and at Columbia Engineering and leader of the Center for Functional Nanomaterials’ Soft and Bio Nanomaterials Group at Brookhaven National Laboratory.

“The capabilities to manufacture 3D nanoscale materials by design are critical for many emerging applications, ranging from light manipulation to neuromorphic computing, and from catalytic materials to biomolecular scaffolds and reactors,” said Gang.

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