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Category: nanotechnology – Page 4

Harvard University and the Chinese University of Hong Kong researchers have developed a technique that increases the solubility of drug molecules by up to three orders of magnitude. This could be a breakthrough in drug formulation and delivery.

Over 60% of pharmaceutical drug candidates suffer from poor water solubility, which limits their bioavailability and therapeutic viability. Conventional techniques such as particle-size reduction, solid dispersion, lipid-based systems, and mesoporous confinement often have drug-specific limitations, can be costly to implement, and are prone to stability issues.

The newly developed approach addresses these issues by leveraging the competitive adsorption mechanism of drug molecules and water on engineered silica surfaces. It avoids chemical modification of drug molecules or using additional solubilizing agents to achieve solubility, potentially replacing multiple drug delivery technologies.

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Particle detectors play a crucial role in our understanding of the fundamental building blocks of the universe. They allow scientists to study the behavior and properties of the particles produced in high-energy collisions. Such particles are boosted to near the speed of light in large accelerators and then smashed into targets or other particles where they are then analyzed with detectors. Traditional detectors, however, lack the needed sensitivity and precision for certain types of research.

Researchers at the U.S. Department of Energy’s (DOE) Argonne National Laboratory have made a significant breakthrough in the field of high-energy particle detection in recent experiments conducted at the Test Beam Facility at DOE’s Fermi National Accelerator Laboratory (Fermilab).

They have found a new use for the superconducting nanowire photon detectors (SNSPDs) already employed for detecting photons, the fundamental particles of light. These incredibly sensitive and precise detectors work by absorbing individual photons. The absorption generates small electrical changes in the superconducting nanowires at very low temperatures, allowing for the detection and measurement of photons. Specialized devices able to detect individual photons are crucial for quantum cryptography (the science of keeping information secret and secure), advanced optical sensing (precision measurement using light) and quantum computing.

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Another question is how bacteria form these tubes, and under what conditions. The tubes are not much longer than an individual cell, and Prochlorococcus, in particular, is thought to spread out in the water column. Muñoz-Marín and her team are curious about the concentrations of bacteria required for a network to form. “How often would it be possible for these independent cells to get close enough to each other in order to develop these nanotubes?” García-Fernandez asked. The current study shows that nanotubes do form among wild-caught cells, but the precise requirements are unclear.

Looking back at what people thought about bacterial communication when he began to study marine cyanobacteria 25 years ago, García-Fernandez is conscious that the field has undergone a sea change. Scientists once thought they saw myriad individuals floating alongside each other in immense space, competing with neighboring species in a race for resources. “The fact that there can be physical communication between different kind of organisms—I think that changes many, many previous ideas on how the cells work in the ocean,” he said. It’s a far more interconnected world than anyone realized.

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The rapid technological advancements of our world have been enabled by our capacity to design and fabricate ever smaller electronic chips. These underpin computers, mobile phones and every smart device deployed to date.

One of the many challenges is that electronic components generate increasingly more heat as they are miniaturized. A significant issue lies in making the wires which connect the transistors on the chip thinner while ensuring that the minimum amount of heat is released.

These interconnects are typically made from copper, and as we start to scale them down to nano-scale thicknesses, their electrical resistance increases rapidly because the electrons moving along the wires have a higher probability of colliding into the surface of the wire. Known as scattering, this leads to energy being released in the form of waste heat, meaning you need more power to maintain the same level of performance.

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The automated synthesis of plasmonic nanoparticles with on-demand properties is a challenging task. Here the authors integrate a fluidic reactor, real-time characterization, and machine learning in a self-driven lab for the photochemical synthesis of nanoparticles with targeted properties.

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Scientists have translated nanoscale experimental and computational data into precise 3D representations of bacteria, yeast and human epithelial, breast and breast cancer cells in Minecraft, a video game that allows players to explore, build and manipulate structures in three dimensions.

The innovation will allow researchers and students of all ages to navigate biological cells, puncturing through the membranes of organelles to view their interiors or wandering across the cytoplasm to see how the various structures are distributed within the cell.

“CraftCells: A Window into Biological Cells” is the first broadly accessible tool allowing users to get an accurate picture of whole cells in 3D, said Zaida (Zan) Luthey-Schulten, a professor of chemistry and of physics at the University of Illinois Urbana-Champaign who led the work with Illinois bioengineering professors Stephen Boppart and Rohit Bhargava, graduate student Kevin Tan, postdoctoral researchers Zane Thornburg and Seth Kenkel, and study lead author Tianyu Wu, a biophysics graduate student at the U. of I.

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The phase and the group velocity of light propagating in conventional optical media cannot exceed the speed of light in vacuum. However, in so-called epsilon-near-zero (ENZ) materials, light exhibits an infinite phase velocity and a vanishing group velocity for a particular color (frequency).

So far, such properties have only been observed in very few solids and nano-engineered materials. A new study by researchers from the Max Born Institute in Berlin and Tulane University in New Orleans opens a completely new avenue by transiently turning ordinary liquids, such as water and alcohols, into ENZ materials at terahertz (THz) frequencies through the interaction with intense femtosecond laser pulses.

Ionization of a polar molecular liquid with generates , which localize or “solvate” on a femtosecond time scale and eventually occupy voids in the network of molecules, a disordered array of electric dipoles. The binding energy of the electron in its final location is mainly determined by electric forces between the electron and the molecular dipoles of the liquid.

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A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed into mRNA precursors, is correctly assembled into mature mRNA. Splicing is a basic requirement for producing proteins that fulfill an organism’s vital functions. Faulty functioning of a spliceosome can lead to a variety of serious diseases.

Researchers at the Heidelberg University Biochemistry Center (BZH) have succeeded for the first time in depicting a faulty “blocked” at high resolution and reconstructing how it is recognized and eliminated in the cell. The research was published in Nature Structural & Molecular Biology.

The of all living organisms is contained in DNA, with the majority of genes in higher organisms being structured in a mosaic-like manner. So the cells are able to “read” the instructions for building proteins stored in these genetic mosaic particles, they are first copied into precursors of mRNA, or messenger RNA. The spliceosome then converts them into mature, functional mRNA.

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LiDAR, or Light Detection and Ranging, works by measuring the time it takes for a laser pulse to travel to an object and back. This time-of-flight measurement reveals the distance, and by scanning across an area, a 3D image is created.

This new tech utilizes a superconducting nanowire single-photon detector (SNSPD), an ultrasensitive detector developed by the MIT and NASA Jet Propulsion Laboratory.

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