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Category: nanotechnology – Page 8

Nanoparticle-cell interface enables electromagnetic wireless programming of mammalian transgene expression

Recent technological advances are fueling the development of cutting-edge technologies that can monitor and control physiological processes with high precision. These include devices that could control the expression of genes within living organisms, without requiring invasive surgeries or procedures.

Researchers at ETH Zurich recently introduced a new method that enables the electromagnetic programming of the wireless expression regulation (EMPOWER) of transgenes in mammals, via the interfacing of and cells.

Their proposed approach, outlined in a paper published in Nature Nanotechnology, could help to treat , including diabetes, while also opening new possibilities for research in synthetic biology and regenerative medicine.

Quantum simulation captures light-driven chemical changes in real molecules for the first time

Researchers at the University of Sydney have successfully performed a quantum simulation of chemical dynamics with real molecules for the first time, marking a significant milestone in the application of quantum computing to chemistry and medicine.

Understanding in real time how atoms interact to form new compounds or interact with light has long been expected as a potential application of quantum technology. Now, quantum chemist Professor Ivan Kassal and Physics Horizon Fellow Dr. Tingrei Tan have shown it is possible using a quantum machine at the University of Sydney.

The innovative work leverages a novel, highly resource-efficient encoding scheme implemented on a trapped-ion quantum computer in the University of Sydney Nanoscience Hub, with implications that could help transform medicine, energy and materials science.

Emerging non-viral vectors for gene delivery

The development of COVID-19 vaccines has sparked widespread interest. mRNA-based therapies are rapidly gaining attention owing to their unique advantages in quickly developing vaccines and immunotherapy for various ailments [1, 2]. Given that most human diseases stem from genetic factors, gene therapy represents a promising modality for addressing various inherited or acquired disorders by replacing faulty genes or silencing genes [3]. Gene therapy encompasses the targeted exploitation of genetic material, which includes gene replacement through DNA or mRNA [4, 5]; gene silencing utilizing siRNA or miRNA [6], and CRISPR-Cas9 based gene editing [7].

However, achieving safe and efficient gene delivery to specific cells requires overcoming multiple biological barriers, including extracellular obstacles such as enzyme degradation, serum protein interactions, electrostatic repulsion of genes and cell membranes, and innate immune system, as well as intracellular obstacles such as endosomal escape, transport barriers, precise release [8]. Therefore, gene vectors require several characteristics such as high gene condensation; favorable serum stability to avoid non-specific serum protein interactions, endonuclease degradation, and renal clearance; achieved specific targeting cell or tissues; effective transport into the cytoplasm thereby facilitating gene transfection (mRNA, siRNA and miRNA); precise gene release and scheduling, and nuclear localization that enables DNA transcription. Comprehensive exploration of transfection mechanisms can aid in the development of high-performance gene vectors [9, 10].

Gene vectors generally include viral vectors and non-viral vectors. Presently, approximately 70% of clinical gene therapy trials employ viral vectors, which include retroviruses, lentiviruses, adenoviruses, and adeno-associated viruses. Due to their exceptional infectivity, virus-based vectors typically exhibit excellent gene transfection capabilities. However, the clinical safety of viral vectors has been questioned due to their propensity to stimulate immunogenic reactions and induce transgene insertion mutations. Moreover, viral vectors possess several limitations, including low gene loading capacity, inability to deliver large-sized genes, complicated preparation procedures, and the patient cannot be repeatedly administered [4]. In contrast, non-viral vectors, particularly lipid nanoparticles (LNPs) and cationic polymers, have demonstrated robust gene loading capacity, heigh safety and practicability, simplicity preparation [10, 11]. Consequently, non-viral vectors are exhibiting tremendous potential for further clinical development and application. Our review primarily highlights the significant potential of non-viral vectors, particularly lipid nanoparticles (LNPs), highly branched poly(β-amino ester) (HPAE), single-chain cyclic polymer (SCKP), poly(amidoamine) (PAMAM) dendrimers, and polyethyleneimine (PEI). We intend to provide a detailed examination of the latest research progress and existing limitations of non-viral gene vectors over recent years.

Functional Biomaterials for Drug Delivery

Gene therapy is a technique that rectifies defective or abnormal genes by introducing exogenous genes into target cells to cure the disease. Although gene therapy has gained some accomplishment for the diagnosis and therapy of inherited or acquired cardiovascular diseases, how to efficiently and specifically deliver targeted genes to the lesion sites without being cleared by the blood system remains challenging. Based on nanotechnology development, the non-viral vectors provide a promising strategy for overcoming the difficulties in gene therapy. At present, according to the physicochemical properties, nanotechnology-based non-viral vectors include polymers, liposomes, lipid nanoparticles, and inorganic nanoparticles. Non-viral vectors have an advantage in safety, efficiency, and easy production, possessing potential clinical application value when compared with viral vectors. Therefore, we summarized recent research progress of gene therapy for cardiovascular diseases based on commonly used non-viral vectors, hopefully providing guidance and orientation for future relevant research.

Cardiovascular disease (CVD) leads to almost a third of all deaths worldwide, resulting from atherosclerotic plaque leading to hemadostenosis and blood flow restriction (Park et al., 2020; Tsao et al., 2022). Despite progress in medical technology, CVD is still a major cause of death (Yang et al., 2023). Conventional treatment strategies for CVD include anticoagulation, antiplatelet, thrombolytics, hypolipidemic drugs, and invasive therapies like vascular bypass grafting and stent transplantation (Zhu et al., 2021). However, small molecule drug therapy in conventional treatment strategies is characterized by short half-life and low bioavailability, and long-term use of certain drugs may also lead to side effects such as drug resistance and potential hematological toxicity (Missri, 1979; Fu et al., 2014). Surgical treatment, on the other hand, is more pro-traumatic, requires a longer recovery time, and has a high risk of postoperative complications.

Finely-tuned TiO₂ nanorod arrays enhance solar cell efficiency

A research team led by Prof. Wang Mingtai at the Hefei Institutes of Physical Science of the Chinese Academy of Sciences has developed a finely tuned method for growing titanium dioxide nanorod arrays (TiO2-NA) with controllable spacing without changing individual rod size and demonstrated its application in high-performance solar cells.

Their findings, published in Small Methods, offer a new toolkit for crafting nanostructures across clean energy and optoelectronics.

Single-crystalline TiO2 nanorods excel at harvesting light and conducting charge, making them ideal for solar cells, photocatalysts, and sensors. However, traditional fabrication methods link rod density, diameter, and length—if one parameter is adjusted, the others shift accordingly, often affecting device efficiency.

Carbon nanotubes release more energetic light than they receive, could help solar power

The mechanism can also create better biological imaging tools to see deep inside tissues using safer infrared light. It could even cool materials with lasers, by removing thermal energy through UCPL.

“By establishing an intrinsic model of UCPL in single-walled carbon nanotubes, we hope to open up new possibilities for designing advanced optoelectronic and photonic devices,” added Kato.

What the RIKEN scientists have essentially discovered is that one does not need structural defects for up-conversion in carbon nanotubes. Instead, phonons and dark excitons do the trick. This opens up cleaner, more efficient, and more flexible designs for future energy and photonic technologies.

Nanoscale spectroscopy detects vibrational signals from molecules in confined gaps

Vibrational sum-frequency generation (VSFG) is a nonlinear spectroscopic method widely used to investigate the molecular structure and dynamics of surface systems. However, in far-field observations, the spatial resolution of this method is constrained by the diffraction limit, which restricts its ability to resolve molecular details in inhomogeneous structures smaller than the wavelength of light.

To address this limitation, researchers, Atsunori Sakurai, Shota Takahashi, Tatsuto Mochizuki, and Toshiki Sugimoto, Institute for Molecular Science (IMS), NINS, developed a tip-enhanced VSFG (TE-SFG) spectroscopy system based on scanning tunneling microscopy (STM). Using this system, the team detected VSFG signals from molecules adsorbed on a gold substrate under ambient conditions.

The research is published in the journal Nano Letters.

New quantum gravity discovery could unite quantum mechanics and relativity

Two recent advances—one in nanoscale chemistry and another in astrophysics—are making waves. Scientists studying the movement of molecules in porous materials and researchers observing rare cosmic events have uncovered mechanisms that could reshape both industry and our view of the universe.

One of the most promising fields in material science centers on molecular diffusion. This is the way molecules move through small, confining spaces—a key process behind technologies like gas separation, catalysis, and energy storage. Materials called MOFs, short for metal-organic frameworks, have emerged as powerful tools because of their flexible structure and tunable chemistry.

Yet predicting how molecules behave inside these frameworks isn’t simple. Pore size, shape, chemical reactivity, and even how the material flexes all play a role. Studying these factors one by one has been manageable. But understanding how they work together to control molecular flow remains a major hurdle for material designers.

These DNA-sized nanobots are made for walking and sorting molecular cargo

The field of nanotechnology is still in its nascent stages, but recent innovations are increasingly making this science fiction world of tiny robots into a reality. New breakthrough research from a team at Caltech has demonstrated the ability of a robot made of a single strand of DNA to explore a molecular surface, pick up targeted molecules, and move them to another designated location.

“Just like electromechanical robots are sent off to faraway places, like Mars, we would like to send molecular robots to minuscule places where humans can’t go, such as the bloodstream,” says Lulu Qian, co-author on the paper. “Our goal was to design and build a molecular robot that could perform a sophisticated nanomechanical task: cargo sorting.”

Previous work by a variety of researchers has successfully demonstrated the creation of such DNA robots, but this is the first time they have been shown to pick up and transport specific molecules.