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A combination of mRNA and a new lipid nanoparticle could help heal damaged lungs, according to new research from the Perelman School of Medicine at the University of Pennsylvania. Viruses, physical trauma, or other problems can have a serious impact on the lungs, and when the damage is in the lower regions, traditional treatments, like inhaled medication, might not work. The study, published in Nature Communications, provides a proof of concept for an injectable therapy.

“The lungs are hard-to-treat organs because both permanent and temporary damage often happen in the deeper regions where medication does not easily reach,” said study author Elena Atochina-Vasserman, MD, Ph.D., research assistant professor of Infectious Diseases at Penn and scientist at the Penn Institute for RNA Innovation. “Even drugs delivered intravenously are spread without specificity. That makes a targeted approach like ours especially valuable.”

Lung damage can result from a variety of causes ranging from physical accidents that cause inflammation of the lungs to like COVID, flu, and RSV. Viruses alone can usher in an setting off a buildup of fluid in the airways, excess mucus, , and damage to the lining of the lungs. Whether acute or chronic, weakened lungs can be life threatening. Respiratory diseases were the third leading cause of death worldwide even before the pandemic, according to previous research.

Scientists have created a hydrogel that strengthens bones in weeks. Bone density increased by 5X in a lab.

A groundbreaking injectable hydrogel may soon offer a faster, more effective treatment for osteoporosis, a condition that weakens bones and increases fracture risk.

Developed by researchers at EPFL in Switzerland and startup Flowbone, this new hydrogel, made from hyaluronic acid and hydroxyapatite nanoparticles, mimics bone’s natural minerals and strengthens fragile areas. In lab tests on rats, the treatment increased bone density by up to three times within weeks. When combined with the osteoporosis drug Zoledronate, bone density at the injection site increased nearly fivefold, potentially reducing the risk of fractures far more quickly than current medications.

While the hydrogel is not a permanent fix, researchers believe it could revolutionize osteoporosis management by complementing existing drug therapies and speeding up recovery. Given that osteoporosis affects millions worldwide—especially postmenopausal women—this breakthrough could significantly lower the risk of life-threatening fractures. The team now aims to secure regulatory approval and begin clinical trials, bringing this promising technology one step closer to real-world use. If successful, it could redefine how osteoporosis is treated, offering patients faster relief and stronger bones.


Managing osteoporotic patients at immediate fracture risk is challenging, in part due to the slow and localized effects of anti-osteoporotic drugs. Combining systemic anti-osteoporotic therapies with local bone augmentation techniques offers a promising strategy, but little is known about potential interactions. We hypothesized that integrating systemic treatments with local bone-strengthening biomaterials would have an additive effect on bone density and structure. This study investigated interactions and synergies between systemic therapies and injectable biomaterials, HA2 and HA2-ZOL, designed for local bone strengthening. HA2-ZOL incorporates Zoledronate, a bisphosphonate, to enhance anti-resorptive effects. These materials were tested in an in vivo rat model of osteoporosis using microCT and histology.

Thirty-six ovariectomized Wistar rats were treated systemically with vehicle (VEH), alendronate (ALN), or parathyroid hormone (PTH). One week later, their tibiae were randomly assigned to local treatment groups: HA2, HA2-ZOL, or NaCl control. Bilateral injections targeted metaphyseal trabecular bone, with microCT scans tracking changes over 8 weeks. Regions of interest (ROIs) were identified and analyzed for bone volume fraction (BV/TV), tissue mineral density (TMD), and trabecular morphology. Histological analyses were performed at week 8 to assess bone structure and mineral inclusions.

DGIST research teams have developed a self-powered sensor that uses motion and pressure to generate electricity and light simultaneously. This battery-free technology is expected to be used in various real-life applications, such as disaster rescue, sports, and wearable devices.

Triboelectric nanogenerators (TENG) and mechanoluminescence (ML) have attracted attention as green energy technologies that can generate electricity and light, respectively, without external power. However, researchers in previous studies mainly focused on the two technologies separately or simply combined them. Moreover, the power output stability of TENG and the insufficient luminous duration of ML materials have been major limitations for practical applications.

The research team has developed a system that generates electricity and light simultaneously using motion and pressure. They added light-emitting zinc sulfide-copper (ZnS: Cu) particles to a rubber-like material (polydimethylsiloxane [PDMS]) and designed a single electrode structure based on silver nanowires to obtain high efficiency. The developed device does not degrade in performance even after being repeatedly pressed more than 5,000 times, and it stably generates voltages of up to 60 V and a current of 395 nA.

As the fundamental flaw of today’s quantum computers, improving qubit stability remains the focus of much research in this field. One such stability attempt involves so-called topological quantum computing with the use of anyons, which are two-dimensional quasiparticles. Such an approach has been claimed by Microsoft in a recent paper in Nature. This comes a few years after an earlier claim by Microsoft for much the same feat, which was found to be based on faulty science and hence retracted.

The claimed creation of anyons here involves Majorana fermions, which differ from the much more typical Dirac fermions. These Majorana fermions are bound with other such fermions as a Majorana zero mode (MZM), forming anyons that are intertwined (braided) to form what are in effect logic gates. In the Nature paper the Microsoft researchers demonstrate a superconducting indium-arsenide (InAs) nanowire-based device featuring a read-out circuit (quantum dot interferometer) with the capacitance of one of the quantum dots said to vary in a way that suggests that the nanowire device-under-test demonstrates the presence of MZMs at either end of the wire.

Microsoft has a dedicated website to their quantum computing efforts, though it remains essential to stress that this is not a confirmation until their research is replicated by independent researchers. If confirmed, MZMs could provide a way to create more reliable quantum computing circuitry that does not have to lean so heavily on error correction to get any usable output. Other, competing efforts here include such things as hybrid mechanical qubits and antimony-based qubits that should be more stable owing to their eight spin configurations.

Researchers, including those from the University of Tokyo, developed Deep Nanometry, an analytical technique combining advanced optical equipment with a noise removal algorithm based on unsupervised deep learning.

Deep Nanometry can analyze nanoparticles in medical samples at high speed, making it possible to accurately detect even trace amounts of rare particles. This has proven its potential for detecting indicating early signs of colon cancer, and it is hoped that it can be applied to other medical and industrial fields.

The body is full of smaller than cells. These include extracellular vesicles (EVs), which can be useful in early disease detection and also in drug delivery.

Plastic that conducts electricity might sound impossible. But there is a special class of materials known as “electronic polymers” that combines the flexibility of plastic with the functionality of metal. This type of material opens the door for breakthroughs in wearable devices, printable electronics and advanced energy storage systems.

Yet, making thin films from electronic polymers has always been a difficult task. It takes a lot of fine-tuning to achieve the right balance of physical and . Researchers at the U.S. Department of Energy’s (DOE) Argonne National Laboratory have created an innovative solution to this challenge with artificial intelligence (AI).

They used an AI-driven, automated materials laboratory, a tool called Polybot, to explore processing methods and produce high-quality films. Polybot is located at the Center for Nanoscale Materials, a DOE Office of Science user facility at Argonne.

Finding the right lubricant for the right purpose is a task that is often extremely important in industry. Not only to reduce friction, overheating and wear, but also to save energy. At TU Wien, the research groups of Prof Carsten Gachot (Tribology, Mechanical Engineering) and Prof Dominik Eder (Chemistry) are therefore working together to develop innovative, improved lubricants.

The team has now presented a new type of material with special properties: The lubricant COK-47 is not liquid like lubricating oil, but a powdery solid substance. On a nanoscale, it consists of stacks of atomically thin sheets, like a tiny stack of cards.

When the material comes into contact with , these platelets can slide past each other very easily—a so-called tribofilm is created, which ensures extremely low . This makes COK-47 a highly interesting in .

Researchers have developed a freely available droplet microfluidic component library, which promises to transform the way microfluidic devices are created. This innovation, based on low-cost rapid prototyping and electrode integration, makes it possible to fabricate microfluidic devices for under $12 each, with a full design-build-test cycle completed within a single day. The components are biocompatible, high-throughput, and capable of performing multistep workflows, such as droplet generation, sensing, sorting, and anchoring, all critical for automating microfluidic design and testing.

Microfluidics, particularly droplet-based systems, has become a promising technology for diverse fields, including protein engineering, single-cell sequencing, and nanoparticle synthesis. However, the traditional methods of fabricating —typically using PDMS (polydimethylsiloxane)—are time-consuming and costly, often requiring cleanroom facilities or external vendors.

While alternatives like laser cutting and 3D printing have been explored, these methods often suffer from limitations in resolution, material compatibility, and scalability. As a result, there has been an urgent need for a more efficient, cost-effective, and accessible fabrication method to help propel innovation in microfluidic technology.