Lifeboat Foundation: Safeguarding Humanity
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Category: life extension – Page 50

Open House

Have you heard about the crazy guys who bought an entire tower to convert it into a vertical village? Yes, that’s us.

Do you want to walk the 16-floor tower and explore the space? Still on the fence, if you should become a citizen? Do you have questions about how you can get involved and co-create? Wanna hear updates on what happened in the last 2 weeks? This event is for you! 👩‍🚀

About us: We are transforming a 16-floor tower in the heart of San Francisco into a self-governed vertical village —a hub for frontier technologies and creative arts. 8 themed floors will be dedicated to creating tier-one labs, spanning AI, Ethereum, biotech, neuroscience, longevity, robotics, human flourishing, and arts & music. These floors will house innovators and creators pushing the boundaries of human potential in a post-AI-singularity world.

Mimicking the benefits of exercise with a single molecule

Capital Medical University, in collaboration with the Chinese Academy of Sciences, reports that betaine, a molecule produced in the kidney and enhanced through sustained exercise, operates as a potent inhibitor of inflammatory and aging-related pathways.

Regular physical activity boosts health across cardiovascular, metabolic, and neurological systems. Scientists have traced improvements in , , clearing of senescent cells and to consistent physical activity. Earlier animal studies suggested that long-term exercise can delay aging processes and reduce vulnerability to chronic disease.

Precise molecular explanations for how sustained exercise reshapes human biology remain incomplete. Many investigations have focused on single biomarkers or isolated tissues, leaving a need for systematic maps that can connect exercise to measurable physiological benefits. Specific factors capable of mimicking exercise’s protective effects without requiring continuous physical exertion have remained unclear.

Scientists reprogram ant behavior using brain molecules

Leafcutter ants live in highly organized colonies where every ant has a job, and now researchers can flip those jobs like a switch. By manipulating just two neuropeptides, scientists can turn defenders into nurses or gardeners into leaf harvesters. These same molecular signals echo in naked mole-rats, revealing a deep evolutionary link in how complex societies function, even across species. The study also teases out a possible connection to insulin and longevity, hinting at new frontiers in understanding human behavior and lifespan.

Aging-related inflammation is not universal across human populations, new study finds

Inflammation, long considered a hallmark of aging, may not be a universal human experience, according to a new study from Columbia University Mailman School of Public Health. The research suggests that “inflammaging”—chronic, low-grade inflammation associated with aging—appears to be a byproduct of industrialized lifestyles and varies significantly across global populations.

The findings are published in Nature Aging.

Researchers analyzed data from four populations: two industrialized groups—the Italian InCHIANTI study and the Singapore Longitudinal Aging Study (SLAS)—and two Indigenous, non-industrialized populations—the Tsimane of the Bolivian Amazon and the Orang Asli of Peninsular Malaysia. While the inflammaging signature was similar between the two industrialized populations, it did not hold in the Indigenous groups, where levels were largely driven by rather than age.

Blood Test #4 in 2025: 17y Younger Biological Age

Join us on Patreon! https://www.patreon.com/MichaelLustgartenPhD

Discount Links/Affiliates:
Blood testing (where I get the majority of my labs): https://www.ultalabtests.com/partners/michaellustgarten.

At-Home Metabolomics: https://www.iollo.com?ref=michael-lustgarten.
Use Code: CONQUERAGING At Checkout.

Clearly Filtered Water Filter: https://get.aspr.app/SHoPY

Epigenetic, Telomere Testing: https://trudiagnostic.com/?irclickid=U-s3Ii2r7xyIU-LSYLyQdQ6…M0&irgwc=1
Use Code: CONQUERAGING

NAD+ Quantification: https://www.jinfiniti.com/intracellular-nad-test/

Continue reading “Blood Test #4 in 2025: 17y Younger Biological Age” | >

Calorie restriction mimetics against aging and inflammation

Geroprotectors, a class of compounds that ameliorate molecular, cellular, or physiological aging-related alterations, have garnered significant attention in the quest to promote healthy aging and extend the human health span. Among these, Calorie Restriction Mimetics (CRMs) have emerged as promising candidates due to their potential to mimic the benefits of calorie restriction, a dietary approach involving reduced calorie intake without malnutrition. Prospective CRMs may include biguanides (metformin and aminoguanidine), which exert effects on the insulin signaling pathway; rapamycin, which interacts with mTOR signaling pathways; and stilbenes (resveratrol), which influences stress signaling pathways and promotes the activation of AMPK, impacting mitochondrial metabolism in addition to the activity of FOXO and sirtuin.

Muscle in Space Sheds Light on Ageing-Related Muscle Loss

Sarcopenia, which is a progressive and extensive decline in muscle mass and strength, is common with aging and estimated to affect up to 50% of people aged 80 and older. It can lead to disability and injuries from falls and is associated with a lower quality of life and an increased mortality. Apart from lifestyle changes, there is no current clinical treatment for sarcopenia.

Space flight with the associated absence of gravity and limited strain on muscles causes muscle weakness, a prominent feature of sarcopenia, within a short period of time, providing a time lapse view on age-related atrophy-associated changes in the muscle. This relatively short window of time in space provides a microgravity model for muscular aging and opens opportunities for studying sarcopenia, which normally takes decades to develop in patients on earth.

To understand the changes of muscle in microgravity, Siobhan Malany, Maddalena Parafati, and their team from the University of Florida, USA, engineered skeletal muscle microtissues from donor biopsies and launched them to the International Space Station (ISS) aboard SpaceX CRS-25. Their findings were published today in Stem Cell Reports. The microtissues were taken from both young, active donors and from aged, sedentary donors and cultured in an automated mini lab, which besides regular feeding and monitoring of cultures also enabled electrical stimulation to simulate exercise. On earth, the contraction strength of microtissues from young, active individuals was almost twice as much as the strength of tissues from older, sedentary individuals. After only two weeks in space, muscle strength trended to decline in the young tissues and was now more comparable to the strength of old tissues. A similar trend was seen for the muscle protein content, which was higher in young microtissues on earth compared to old microtissues but decreased in microgravity to levels measured in old tissues. Further, space flight changed gene expression, particularly in the younger microtissues and disturbed cellular processes related to normal muscle function. Interestingly, electrical stimulation could mitigate these changes in gene expression to some extent.

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