Surprising findings on bacterial aging have emerged from a study carried out by a team of researchers led by the biologist Dr. Ulrich Steiner at Freie Universität Berlin. In a new paper published in Science Advances, the team demonstrated that even genetically identical bacterial cells living in the same environment react differently to the aging process and that changes occur at different rates within different regions of the cell.
Abstract. Type H vessels have been proven to couple angiogenesis and osteogenesis. The decline of type H vessels contributes to bone loss in the aging process. Aging is accompanied by the accumulation of advanced oxidation protein products (AOPPs). However, whether AOPP accumulation is involved in age-related decline of type H vessels is unclear. Here, we show that the increase of AOPP levels in plasma and bone were correlated with the decline of type H vessels and loss of bone mass in old mice. Exposure of microvascular endothelial cells to AOPPs significantly inhibited cell proliferation, migration, and tube formation, increased NADPH oxidase activity and excessive reactive oxygen species generation, upregulated the expression of vascular cell adhesion molecule-1 and intercellular cell adhesion molecule-1, and eventually impaired angiogenesis, which was alleviated by redox modulator N-acetylcysteine and NADPH oxidase inhibitor apocynin. Furthermore, reduced AOPP accumulation by NAC treatment was able to alleviate significantly the decline of type H vessels, bone mass loss and deterioration of bone microstructure in old mice. Collectively, these findings suggest that AOPPs accumulation contributes to the decline of type H vessels in the aging process, and illuminate a novel potential mechanism underlying age-related bone loss.
To learn more, a research team led by Drs. Asghar Rezaei and Kenton Kaufman of the Mayo Clinic set out to assess gait, balance, and strength in healthy people over age 50. Their study enrolled 40 participants. Half were between ages 50 and 64. The rest were ages 65 or older. In each group, half of the participants were female, and half were male.
Each participant underwent a series of tests in a motion analysis lab. Reflective markers were attached to specific locations on each participant’s feet, thighs, pelvis, head, and more. To assess gait, a 14-camera motion capture system recorded marker movements as people walked back and forth on an eight-meter-long walkway. Force plates on the floor measured ground reaction forces to detect changes in the center of pressure. Balance tests similarly used force plates to record movements and center of pressure data. The balance tests assessed the body’s sway as people stood on one leg with eyes open and on both legs with eyes open and closed. Grip strength and knee strength were measured by using specialized devices. Results were reported on October 23, 2024, in PLOS ONE.
The researchers found that gait characteristics—including walking speed and stride length—were not significantly affected by age. In contrast, several measures of balance and strength showed significant age-related reductions.
Researchers at Wenzhou Medical University in China have discovered that changes in sleep patterns as we age are associated with lower odds of successful aging.
A team of scientists from the Chinese Academy of Sciences (CAS) and BGI Research has uncovered the intricate mechanisms by which immunoglobulins influence the aging process, a finding that might reshape our understanding of aging.
Changes to actin dynamics during brain aging are not well understood. Here, the authors report that there is an age-related increase in F-actin in Drosophila brain which disables autophagy within the tissue and limits the fly lifespan.
We use our lips to talk, eat, drink, and breathe; they signal our emotions, health, and aesthetic beauty. It takes a complex structure to perform so many roles, so lip problems can be hard to repair effectively. Basic research is essential to improving these treatments, but until now, models using lip cells—which perform differently to other skin cells—have not been available.
In a study published in Frontiers in Cell and Developmental Biology, scientists report the successful immortalization of donated lip cells, allowing for the development of clinically relevant lip models in the lab. This proof-of-concept, once expanded, could benefit thousands of patients.
“The lip is a very prominent feature of our face,” said Dr. Martin Degen of the University of Bern.
When things get tough in adulthood, it might seem appealing to return to simpler times.
One bizarre marine creature has taken this approach to dire situations quite literally, regressing its physical adult body to a juvenile stage once the stress of starvation or injury has subsided.
Until now, the immortal jellyfish (Turritopsis dohrnii) was the only species thought to be able to wind back the clock on jelly-puberty like this, but now it’s joined by Mnemiopsis leidyi, better known as the sea walnut or the warty comb jelly.
We all want to ‘age successfully’ with as few health issues as possible. A new study suggests getting more than seven hours of sleep a night could go a long way to achieving that goal.
The study involved 3,306 participants aged 45 and over, whose sleep habits were recorded in 2011, 2013, and 2015, followed by a health check five years later. The data, analyzed by a team from Wenzhou Medical University in China, showed that those who bank at least seven hours of sleep a night tend to have significantly better health later in life.
“Successful aging was evaluated in 2020 and was defined as being free of major chronic diseases, no physical impairment, high cognitive function, good mental health, and active engagement with life,” write the researchers in their published paper.
