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Category: life extension – Page 45

Eli Mohamad & Kai Micah Mills — Advancing Frontiers Of Cryopreservation & Biological Replacement

Biological replacement and cryopreservation to significantly extend human lifespans — eli mohamad & kai micah mills — hydradao and cryodao.

Eli Mohamad is a prominent figure in the biotech, space, and AI industries who has co-founded several successful startups and has a real passion for groundbreaking ventures that focus on the development of futuristic technologies.

Currently as a Core Team Member at CryoDAO (https://www.cryodao.org/), a decentralized organization focused on sourcing and funding research in cryopreservation, Eli continues to work at the forefront of innovative technologies and applies his extensive experience in biotechnology and innovative projects to advance novel cryopreservation technologies and their various applications, from critical tissue and organ preservation, to cryo-sleep and suspended animation for space exploration.

Eli has also been involved in setting up another decentralized organization called HydraDAO (https://hydradao.org/) which is focused on funding and incubating biological replacement research to significantly extend human lifespan and will be looking at everything from Limb Regeneration, Organ Bioprinting and Xenotransplantation, to Progressive Brain Replacement, head/brain transplants, and even whole body replacement via non sentient cloning.

Throughout his career, Eli has held various leadership positions in cutting-edge companies including as Co-founder and Chief Business Officer at X-Therma Inc., a company focused on complex tissue preservation; Advisor and Chief Business Officer at Rimac Automobili, working on high-performance electric vehicles; CFO/CBO at Insilico Medicine, Inc., as well as Co-founder of Organ Preservation Alliance, a non-profit organization dedicated to the future of organ banking, Orphidia Ltd., a medical diagnostics company, and Walkmore, a data science company.

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Slimming significantly alters your microbiome and brain activity

Brain scans show fasting literally rewires your brain:

Brain scans of participants in a recent study showed changes in brain areas that regulate appetite and addiction, including the inferior frontal orbital gyrus. At the same time, tests of stool samples and blood showed changes in the gut bacteria, especially with types called Coprococcus comes and Eubacterium hallii.

The research was published in Frontiers in Cellular and Infection Microbiology.

The team emphasizes that, not only did the participants lose weight, averaging 7.6 kilograms (16.8 pounds), but there were also noticeable changes in the composition of their gut bacteria, and additional changes in brain regions.

These changes were linked to less activity in a part of the brain called the left inferior frontal orbital gyrus, which helps control food intake. During intermittent fasting, certain beneficial gut bacteria may become more prevalent, producing compounds that influence brain activity related to food intake and impulse control.

This suggests a complex, bidirectional communication between the gut and the brain, where altering the gut environment through fasting can lead to changes in brain function, potentially affecting eating behaviors and decision-making processes related to diet. Intermittent fasting offers multiple benefits, including weight loss, improved metabolic health, enhanced brain function, and potential longevity, by altering eating patterns to incorporate regular periods of fasting.

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Scientists engineer nanostructured surfaces hostile to bacteria but friendly to cells

Researchers from Tokyo Metropolitan University have created nanostructured alumina surfaces which are strongly antibacterial but can be used to culture cells. They found that anodic porous alumina (APA) surfaces prepared using electrochemistry in concentrated sulfuric acid had unprecedented resistance to bacterial growth, but did not hamper cell cultures.

The work is published in the journal Langmuir.

The team’s technology promises to have a big impact on regenerative medicine, where high quality cell cultures without bacterial contamination may be produced without antibiotics.

Nithin Kamath shares 92-year-old US professor’s advice on longevity in viral post

Zerodha co-founder Nithin Kamath triggered a conversation online after he shared the wisdom of 92-year-old US-based mathematician and professor Edward Thorp on longevity on social media.

In a post on X, Kamath praised Thorp’s advice, calling it “brilliant” and stating, “This is the only longevity expert you need to listen to.”

Thorp’s message delves into a balanced approach to living a long and healthy life. His philosophy combines “defence,” which involves mitigating risks like cardiovascular diseases through diet, exercise, and regular check-ups, and “offence,” with an emphasis on exercise as a “magic bullet” to extend both lifespan and health span.

Scientists mapped the genome of a shark that can live 400 years. It could unlock new secrets to longevity

DNA that can repair DNA similar to Digital Error Correction!

This could make human live longer!

Before the researchers sequenced the Greenland shark’s genome, only about 10 genomes were available for all elasmobranchs — a subclass of fish including sharks, rays and skates — said Dr. Nicole Phillips, an associate professor of ecology and organismal biology at the University of Southern Mississippi in Hattiesburg. Phillips was not involved in the research conducted by Hoffman, Sahm and their team.

“The more high-quality genomes that are sequenced, the better we can understand the genetic underpinnings of shared as well as unique traits of this ancient group,” Phillips said in an email. “Identification of the genetic basis of lifespans across different species, including long-lived sharks, allows researchers to understand the biology of aging and longevity.”

Because of the sharks’ preference for deep waters, historically most information on the Greenland shark came from commercial fishing records. In the past decade, researchers have increasingly used video, including remotely operated vehicles and baited cameras, as well as observations in captured specimens to research the elusive shark.

Is Longevity Science Worth It?

How long would you like to live, and could science and technology make it possible?

Longevity science aims to extend our healthy years through advancements in CRISPR, cellular reprogramming, and drug development. While private companies and philanthropists invest heavily in these innovations, should the government be responsible for funding these efforts? Those who say yes to government funding say that longevity research could revolutionize public health, keep aging populations productive in the workforce, and reduce the economic burden of age-related illnesses. Those opposed to public funding of longevity science say that true life extension beyond a decade might be unachievable, and it will take years before results are measurable.


They argue that when and if these advances become available, they may only be for a smaller, affluent population. They also argue that long-known behavior choices like good nutrition and sleep should be adopted by all now, instead of chasing uncertain longevity advancements.

With this context, we debate the question: Could Longevity Science Extend Your Health Span By Decades? Should the Government Fund It?

Immunosenescence, Inflammaging, And Immune Resilience: Matt Yousefzadeh, PhD

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Dr. Debra Whitman, Ph.D. — Chief Public Policy Officer, AARP — Author, The Second Fifty

Exploring the most important questions we face as we age.

Dr. Debra Whitman, Ph.D. is Executive Vice President and Chief Public Policy Officer, at AARP (https://www.aarp.org/) where she leads policy development, analysis and research, as well as global thought leadership supporting and advancing the interests of individuals age 50-plus and their families. She oversees AARP’s Public Policy Institute, AARP Research, Office of Policy Development and Integration, Thought Leadership, and AARP International.

Dr. Whitman is an authority on aging issues with extensive experience in national policy making, domestic and international research, and the political process. An economist, she is a strategic thinker whose career has been dedicated to solving problems affecting economic and health security, and other issues related to population aging.

As staff director for the U.S. Senate Special Committee on Aging, Dr. Whitman worked across the aisle to increase retirement security, lower the cost of health care, protect vulnerable seniors, safeguard consumers, make the pharmaceutical industry more transparent, and improve our nation’s long term care system.

Before that, Dr. Whitman worked for the Congressional Research Service as a specialist in the economics of aging. She provided members of Congress and their staff with research and advice, and authored analytical reports on the economic impacts of current policies affecting older Americans, as well as the distributional and intergenerational effects of legislative proposals.

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