A plan to revive the mammoth is on track, scientists have said after creating a new species: the woolly mouse.
Scientists at the US biotechnology company Colossal Biosciences plan to “de-extinct” the prehistoric pachyderms by genetically modifying Asian elephants to give them woolly mammoth traits. They hope the first calf will be born by the end of 2028.
Aging depletes the brain’s protective sugar shield, weakening defenses and fueling cognitive decline, but restoring key sugars may reverse these effects.
What if a critical piece of the puzzle of brain aging has been hiding in plain sight? While neuroscience has traditionally focused on proteins and DNA
DNA, or deoxyribonucleic acid, is a molecule composed of two long strands of nucleotides that coil around each other to form a double helix. It is the hereditary material in humans and almost all other organisms that carries genetic instructions for development, functioning, growth, and reproduction. Nearly every cell in a person’s body has the same DNA. Most DNA is located in the cell nucleus (where it is called nuclear DNA), but a small amount of DNA can also be found in the mitochondria (where it is called mitochondrial DNA or mtDNA).
Researchers at the Arc Institute, Stanford University, and NVIDIA have developed Evo 2, an advanced AI model capable of predicting genetic variations and generating genomic sequences across all domains of life.
Testing shows that Evo 2 accurately predicts the functional effects of mutations across prokaryotic and eukaryotic genomes. It also successfully annotated the woolly mammoth genome from raw genomic sequences without a direct training reference, showing an ability to generalize function from the sequence alone.
Current genomic models struggle with predicting functional impacts of mutations across diverse biological systems, particularly for eukaryotic genomes. Machine learning approaches have demonstrated some success in modeling protein sequences and prokaryotic genomes. The complexity of eukaryotic DNA, with its long-range interactions and regulatory elements, presents more of a challenge.
AI-powered precision in medicine is helping to enhance the accuracy, efficiency, and personalization of medical treatments and healthcare interventions. Machine learning models analyze vast datasets, including genetic information, disease pathways, and past clinical outcomes, to predict how drugs will interact with biological targets. This not only speeds up the identification of promising compounds but also helps eliminate ineffective or potentially harmful options early in the research process.
Researchers are also turning to AI to improve how they evaluate a drug’s effectiveness across diverse patient populations. By analyzing real-world data, including electronic health records and biomarker responses, AI can help researchers identify patterns that predict how different groups may respond to a treatment. This level of precision helps refine dosing strategies, minimize side effects, and support the development of personalized medicine where treatments are tailored to an individual’s genetic and biological profile.
AI is having a positive impact on the pharmaceutical industry helping to reshape how drugs are discovered, tested, and brought to market. From accelerating drug development and optimizing research to enhancing clinical trials and manufacturing, AI is reducing costs, improving efficiency, and ultimately delivering better treatments to patients.
A woman can see nearly 100 million more colors than the rest of us.
This extraordinary ability, known as tetrachromacy, arises from a rare genetic variation that influences the development of the retina, giving her an extra type of cone cell capable of detecting a broader spectrum of light.
While most people have three types of cone cells, allowing them to see around a million colors, tetrachromats have four, enabling them to perceive a staggering range of hues that remain invisible to the average person. For this woman, the world is a kaleidoscope of vibrant, nuanced colors. Ordinary scenes, such as a pathway of pebbles, transform into a dazzling array of oranges, yellows, greens, blues, and pinks, while others see only dull gray.
However, tetrachromacy is not always a blessing. The overwhelming array of colors in environments like grocery stores can be distressing, as the sheer intensity of visual information becomes exhausting. She finds solace in the simplicity of white surfaces, which provide a rare respite from the constant flood of color. Tetrachromacy is thought to be exclusive to women due to its genetic basis. The genes responsible for red and green cone cells are located on the X chromosome. Women, with two X chromosomes, can carry different versions of these genes, potentially resulting in four distinct cone types. While approximately 12% of women may have the genetic potential for tetrachromacy, only a small fraction exhibit the enhanced color perception associated with the condition. Researchers identified the first tetrachromat in 2010. Since then, others have described experiencing a world filled with richer and more nuanced colors.
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As a kid, Concetta Antico was always ‘a bit out of the box’, but it took decades for her to discover just how differently she was seeing the world.
The Bajau tribe of Indonesia have become the first known humans to genetically adapt to diving.
The tribe live an extremely amphibious life, and have now been proven to possess the genetic makeup to do so.
Living off the coasts of Indonesia for more than 1,000 years, the Bajau people live in houseboats, spending a high quantity of their lives in the sea.
Researchers have developed small robots that can work together as a collective that changes shape and even shifts between solid and “fluid-like” states — a concept that should be familiar to anyone still haunted by nightmares of the T-1000 robotic assassin from “Terminator 2.”
A team led by Matthew Devlin of UC Santa Barbara described this work in a paper recently published in Science, writing that the vision of “cohesive collectives of robotic units that can arrange into virtually any form with any physical properties … has long intrigued both science and fiction.”
Otger Campàs, a professor at Max Planck Institute of Molecular Biology and Genetics, told Ars Technica that the team was inspired by tissues in embryos to try and design robots with similar capabilities. These robots have motorized gears that allow them to move around within the collective, magnets so they can stay attached, and photodetectors that allow them to receive instructions from a flashlight with a polarization filter.
A small clinical trial, published in Occupational & Environmental Medicine, suggests that melatonin supplementation may help counteract DNA
DNA, or deoxyribonucleic acid, is a molecule composed of two long strands of nucleotides that coil around each other to form a double helix. It is the hereditary material in humans and almost all other organisms that carries genetic instructions for development, functioning, growth, and reproduction. Nearly every cell in a person’s body has the same DNA. Most DNA is located in the cell nucleus (where it is called nuclear DNA), but a small amount of DNA can also be found in the mitochondria (where it is called mitochondrial DNA or mtDNA).
Humanity came close to extinction 800,000 years ago. Only 1,280 of our ancestors survived.
A recent study published in Science suggests that a catastrophic “ancestral bottleneck” reduced the global population to just 1,280 breeding individuals, wiping out 98.7% of the early human lineage.
This population crash, lasting about 117,000 years, likely resulted from extreme climate shifts, prolonged droughts, and dwindling food sources.
Using a groundbreaking genetic analysis method called FitCoal, researchers analyzed modern human genomes to trace this dramatic decline, potentially explaining a gap in the African and Eurasian fossil record.
Despite the near-extinction, this bottleneck may have played a crucial role in shaping modern humans. Scientists believe it contributed to a key evolutionary event—chromosome fusion—which may have set Homo sapiens apart from earlier hominin species, including Neanderthals and Denisovans. The study raises intriguing questions about how this small population survived, possibly through early fire use and adaptive intelligence. Understanding this ancient crisis helps scientists piece together the story of human evolution and the resilience that allowed our species to thrive against all odds.
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