Toggle light / dark theme

An international team of scientists, including researchers from Harvard University and the University of Zurich, analyzed clinical trial results 777 elderly Swiss adults to test the potential anti-aging benefits of supplements and exercise.

While there’s no perfect way to measure biological aging, the researchers used tools that help measure age-related decline in the cells and organs, including factors like brain health and heart health.

They looked at participants who underwent one of eight longevity treatments over three years, including exercising and supplementing omega-3s, vitamin D, or both.

The term “nanoscale” refers to dimensions that are measured in nanometers (nm), with one nanometer equaling one-billionth of a meter. This scale encompasses sizes from approximately 1 to 100 nanometers, where unique physical, chemical, and biological properties emerge that are not present in bulk materials. At the nanoscale, materials exhibit phenomena such as quantum effects and increased surface area to volume ratios, which can significantly alter their optical, electrical, and magnetic behaviors. These characteristics make nanoscale materials highly valuable for a wide range of applications, including electronics, medicine, and materials science.

DNA (deoxyribonucleic acid), the molecular “blueprint” carrying the genetic instructions that influence the growth, development, reproduction and predispositions of individual humans, can undergo different types of mechanical stress inside cells. For instance, it can be twisted or stretched, impacting its overall structure and dynamics.

Researchers at the University of York recently explored how DNA behaves under torsion and tension using molecular dynamics simulations. These atomic-scale simulations yielded interesting new findings, which were published in a paper in Physical Review Letters.

“I have always been interested in studying how DNA behaves inside the cell,” Dr. Agnes Noy, senior author of the paper, told Phys.org. “We are used to thinking of DNA as a relaxed ‘perfect’ , but the reality is far from that. Inside cells, DNA is under/overtwisted, resulting in the formation of ‘supercoiled’ loops, resembling what can happen to long cords or garden hoses in our homes.”

A metabolomics study pinpointed the differences between leukemia stem cells (LSCs) and their normal counterparts, and suggests elevated levels of spermidine are a signature and a targetable weakness in LSCs.


Spermidine is essential for the function of leukemia stem and progenitor cells through the regulation of KAT7 expression.

Tissue processing advance can label proteins at the level of individual cells across whole, intact rodent brains and other large samples just as fast and uniformly as in dissociated single cells.

Scientists at UC San Francisco have pioneered a groundbreaking approach to fighting cancer using engineered fat cells.

By transforming ordinary fat into high-energy beige fat using CRISPR, they created a cell type that voraciously consumes nutrients — outcompeting and starving tumors.

Revolutionizing cancer treatment: engineered fat cells starve tumors.

Sorry, you’re not Neo and this isn’t “The Matrix.” Michio Kaku gets real about simulation theory.

Up next, Is reality real? These neuroscientists don’t think so ► https://youtu.be/RZdfE_7cde0?si=2-isNPeC1lVvgbiu.

Are we all just living in an elaborate simulation?

After movies like “The Matrix” (1999) posited the existence of a superficial world layered over our own, human imagination has run abound with theories about the nature of our reality. To a small but passionate minority, the red pill that can awaken us to this illusion is right at our fingertips.

World-renowned physicist Michio Kaku isn’t quite ready to take that pill. In fact, he’s skeptical that the pills even exist. He explains why.

Go Deeper with Big Think:

The proportion of people who have never smoked being diagnosed with lung cancer is rising, with new research pointing to air pollution as a growing contributor to lung cancer around the world.

Researchers from the International Agency for Research on Cancer said for never-smokers, lung cancer was the fifth largest leading cause of cancer deaths worldwide. Those cases were nearly exclusively the subtype adenocarcinoma — a tumour that forms in the glandular tissue — and largely in women and Asian populations.

The research, published in The Lancet Respiratory Medicine journal, found nearly 200,000 or about 15 per cent of all adenocarcinoma cases in 2022 were a result of air pollution, suggesting the risk of lung cancer linked to air pollution was also on the rise, particularly in east Asia and China.

Long noncoding RNAs (lncRNAs) are molecules 200 bases in length without protein-coding functions implicated in signal transduction and gene expression regulation via interaction with proteins or RNAs, exhibiting various functions. The expression of lncRNAs has been detected in many cell types, including macrophages, a type of immune cell involved in acute and chronic inflammation, removal of dead or damaged cells, and tissue repair. Increasing evidence indicates that lncRNAs play essential roles in macrophage functions and disease development. Additionally, many animal studies have reported that blockage or modulation of lncRNA functions alleviates disease severity or morbidity rate.

Josh Mitteldorf suggests new protocol for experimental young plasma therapy.

Scientists explore concentrated plasma infusions for stronger anti-ageing effects.

01-Feb-2025Key points from article :

Scientists have long observed the remarkable rejuvenation effects of young plasma in ageing rats, but translating these findings into human therapies has been slow due to intellectual property barriers and funding challenges. In the meantime, a niche industry has emerged in Texas, where ageing individuals can receive plasma infusions from young donors for tens of thousands of dollars. However, these treatments, which replace about 35% of a patient’s plasma, fall short of the dramatic regeneration seen in laboratory animals. Researchers suspect that the exosome dosages in these human procedures are too low to match the full rejuvenation potential seen in rats.

To address this, a new approach suggests concentrating young plasma by removing excess water, allowing for higher doses without overloading the circulatory system. Freeze-drying plasma, a long-standing technology, could be adapted to reconstitute plasma at three or more times its normal strength. However, modifications would be necessary—such as removing platelets to avoid clotting risks and adjusting albumin levels for safety.

A key question remains: Can young exosomes permanently reprogram the body’s ageing process, or will ongoing infusions be required? If the body starts producing its own youthful exosomes after treatment, the therapy could be a game-changer. If not, frequent infusions might be necessary, making the procedure less practical. While uncertainty remains, results from animal studies provide hope that young plasma could lead to longer-lasting rejuvenation in humans.