Phone: 310.423.4471; Email: [email protected]. BK’s present address is: Department of Basic Oncology, Hacettepe University Cancer Institute, Ankara, Turkey. RAP’s present address is: NCI-designated Cancer Center; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California, USA.
Glioblastoma multiforme (GBM) is the most aggressive and lethal type of brain tumor. Both therapeutic resistance and restricted permeation of drugs across the blood–brain barrier (BBB) play a major role in the poor prognosis of GBM patients. Accumulated evidence suggests that in many human cancers, including GBM, therapeutic resistance can be attributed to a small fraction of cancer cells known as cancer stem cells (CSCs). CSCs have been shown to have stem cell-like properties that enable them to evade traditional cytotoxic therapies, and so new CSC-directed anti-cancer therapies are needed. Nanoparticles have been designed to selectively deliver payloads to relevant target cells in the body, and there is considerable interest in the use of nanoparticles for CSC-directed anti-cancer therapies.
A new study from The Wistar Institute has uncovered an unexpected link between fructose—a common dietary sugar—and the spread of an aggressive form of ovarian cancer. Published in Nature Aging, the study found that cancer cells not killed by chemotherapy send signals to neighboring tumor cells, helping them become more capable of spreading.
The researchers identified fructose as a key messenger in this process, revealing a previously unrecognized way that treatment-surviving cancer cells may promote the spread of cancer.
“Some cancer cells that survive chemotherapy aren’t dividing anymore, but they’re still biologically active,” said Aidan Cole, a postdoctoral fellow in the lab of Katherine Aird at The Wistar Institute and first author of the study. “Instead, they continue to release molecules that send signals to nearby cells. Our study is among the first to show that a nutrient—in this case, fructose—can act as one of those signals.”
An interesting report on the phenomenon by which cells and organisms glow very faintly, primarily due to energy transitions during aerobic respiration. Speculation on biological functions and future applications are covered.
Ultra-weak ‘biophotons’ might be used to diagnose disease, or could even represent a new signalling mechanism in cells.
This hypothesis has led to a new “whole-brain” mathematical and computational model developed at the MOX Laboratory of the Department of Mathematics of Politecnico di Milano. The model is designed to describe in an integrated way the interaction between the spread of amyloid beta and the functioning of the cerebral vascular network. The aim is to provide a tool capable of simulating, on the scale of the whole organ, how small biological or vascular alterations can evolve over time and contribute to neurodegeneration. The model and the accompanying scientific study have been published in the prestigious scientific journal Computer Methods in Applied Mechanics and Engineering.
The model integrates two scales of analysis. On the one hand, it describes the dynamics of the production, transformation, diffusion and elimination of the healthy and pathological forms of amyloid beta. On the other, it describes blood flow through a “macroscopic” description of arteries, capillaries and veins, treating brain tissue as a porous medium perfused by blood vessels, through a macroscopic compartmental model. The two components are then connected to represent the possible mechanism of mutual reinforcement between protein accumulation and vascular dysfunction.
The simulations show a particularly relevant result: the brain can evolve into different states depending on the initial conditions. Small localised amounts of amyloid beta can be eliminated, allowing the system to return to a healthy state. Conversely, larger amounts can trigger a self-sustained spread of the pathology at brain scale.
Electrons zipping through transistors, powering the screens on our smartphones. Light zooming from distant stars to Earth, moving faster than anything else in the universe. Protons enabling MRI machines to analyze people’s injuries.
Quantum mechanics explains the behavior of subatomic particles like electrons, photons and protons. In contrast to classical physics that we can observe with our senses, particles in the quantum realm have unusual behaviors. Even though quantum particles make common technologies possible, we don’t experience these behaviors in our everyday world.
That’s why a discovery in 1985 was such a big deal. In a laboratory at the University of California, Berkeley, a team of three scientists showed that a system you could see could demonstrate quantum behavior. Or as they said in one of the journal articles covering the experiments, the system was “big enough to get one’s grubby fingers on.”
Researchers mapped where DNA first opens and how a helicase gate may release one strand as genome copying begins.
Before a cell can divide, it must open its tightly wound DNA and begin copying the entire genome. Researchers at the MRC Laboratory of Medical Sciences (LMS) and collaborating institutions have now traced this process to one of its earliest moments, revealing where DNA first separates inside living cells and identifying a molecular gate that helps launch replication.
Published in Nature Communications, the findings provide a closer view of how cells begin duplicating their genetic material. Because copying errors can damage the genome, the start of DNA replication must be controlled with exceptional precision.
Treating loneliness as a health issue may encourage action while obscuring the broader social conditions behind it.
Loneliness can damage health, but a healthcare system cannot rebuild communities or restore the social connections people have lost. A University of Michigan study warns that defining loneliness mainly as a medical concern may shift responsibility away from the wider social conditions that produce isolation.
Published in Social Problems, the research traces how chronic loneliness and social isolation became widely recognized as public health issues after studies connected them with greater risks of illness, premature death, and increased healthcare spending.