Lifeboat Foundation: Safeguarding Humanity
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Category: biotech/medical – Page 54

Scientists boost mitochondria to burn more calories

Researchers have developed experimental drugs that encourage the mitochondria in our cells to work a little harder and burn more calories. The findings could open the door to new treatments for obesity and improve metabolic health.

Obesity is a global epidemic and a risk factor for many diseases, including diabetes and cancer. Current obesity drugs require injections and can cause side effects, so a safe way to boost weight loss could deliver significant public health benefits.

The study, led by Associate Professor Tristan Rawling from the University of Technology Sydney (UTS), has just been published in Chemical Science, where it was highlighted as “pick of the week.”

An AI-based blueprint for designing catalysts across materials

Hydrogen peroxide is widely used in everyday life, from disinfectants and medical sterilization to environmental cleanup and manufacturing. Despite its importance, most hydrogen peroxide is still produced using large-scale industrial processes that require significant energy. Researchers are thus seeking cleaner alternatives.

A team of researchers has made a breakthrough in this regard, developing a new computational framework that helps identify effective catalysts for producing hydrogen peroxide directly from water and electricity.

The work focuses on the two-electron water oxidation reaction, an electrochemical process that can generate hydrogen peroxide in a more localized and potentially sustainable way.

New research frames psychopathy as a potential survival adaptation to severe early adversity

New research suggests that specific personality traits may amplify the way childhood adversity shapes an individual’s approach to life. A study published in the journal Personality and Individual Differences provides evidence that subclinical psychopathy strengthens the link between childhood trauma and “fast” life history strategies. The findings indicate that for those who have experienced severe early difficulties, certain dark personality traits may function as adaptive mechanisms for survival.

Psychologists use a framework called Life History Theory to explain how people allocate their energy. This theory proposes that all living organisms must make trade-offs between investing in their own growth and investing in reproduction. These trade-offs create a spectrum of strategies that range from “fast” to “slow.”

A fast life history strategy typically emerges in environments that are harsh or unpredictable. Individuals with this orientation tend to prioritize immediate rewards and reproduction over long-term planning. They often engage in riskier behaviors and invest less effort in long-term relationships. This approach makes evolutionary sense when the future is uncertain.

Depression Quietly Damages the Heart Through Stress Circuits

Research from Mass General Brigham suggests that this increased risk is driven by stress-related brain activity, nervous system dysregulation, and chronic inflammation.

They also found that patients with both depression and anxiety were at even higher risk of cardiovascular disease than those diagnosed with just one condition.

Heart-brain connection: International study reveals role of vagus nerve in keeping the heart young

The secret to a healthier and “younger” heart lies in the vagus nerve. A recent study coordinated by the Sant’Anna School of Advanced Studies in Pisa and published in Science Translational Medicine has shown that preserving bilateral cardiac vagal innervation is an anti-aging factor. In particular, the right cardiac vagus nerve emerges as a true guardian of cardiomyocyte health, helping to preserve the longevity of the heart independently of heart rate.

The study is characterized by a strongly multidisciplinary approach, integrating experimental medicine and bioengineering applied to cardiovascular research. Specifically, the research was led by the Translational Critical Care Unit (TrancriLab) of the Interdisciplinary Research Center Health Science, under the responsibility of Professor Vincenzo Lionetti, and by the laboratory of the Biorobotics Institute led by Professor Silvestro Micera, which contributed to the development of the bioabsorbable nerve conduit used to facilitate vagal regeneration.

The study involved a broad network of Italian and international institutions of excellence, including the Scuola Normale Superiore, the University of Pisa, the Fondazione Toscana G. Monasterio, the Institute of Clinical Physiology of the CNR, the University of Udine, GVM Care & Research, Al-Farabi Kazakh National University, the Leibniz Institute on Ageing in Jena and the École Polytechnique Fédérale de Lausanne.

REM sleep reduces subthreshold depolarization in cortical pyramidal neurons in a region-specific manner

Campelo et al. show that REM sleep induces region-specific changes in cortical excitability, with NMDARs playing a crucial role. Diazepam-induced sleep differs from natural sleep by disrupting normal inhibitory circuits, suggesting that hypnotic drugs may compromise sleep-dependent brain functions.

MIT study finds targets for a new tuberculosis vaccine

A large-scale screen of tuberculosis proteins has revealed several possible antigens that could be developed as a new vaccine for TB, the world’s deadliest infectious disease.

In the new study, a team of MIT biological engineers was able to identify a handful of immunogenic peptides, out of more than 4,000 bacterial proteins, that appear to stimulate a strong response from a type of T cells responsible for orchestrating immune cells’ response to infection.

There is currently only one vaccine for tuberculosis, known as BCG, which is a weakened version of a bacterium that causes TB in cows. This vaccine is widely administered in some parts of the world, but it poorly protects adults against pulmonary TB. Worldwide, tuberculosis kills more than 1 million people every year.

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