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FactorBioscience Announces U.S. Department of Defense Grant to Develop Gene-Edited Cell Therapies Read the latest here.

Factor Bioscience Inc. announced the award of a U.S. Department of Defense grant to develop next-generation cell therapy candidates using Factor’s patented mRNA, cell-reprogramming, and gene-editing technologies. The project will be led by Factor’s Co-Founder and Chief Technology Officer, Dr. Christopher Rohde.

Under the award, Factor will generate the first scalable cell therapy specifically targeting muscle inflammation in DMD patients. To carry out the work, Factor will utilize its extensively patented technologies for engineering cells, including methods for reprogramming and gene-editing cells using mRNA.

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Kidney damage from diabetes is called diabetic nephropathy. You can slow down kidney damage or keep it from getting worse. Controlling your blood sugar and blood pressure, taking your medicines and not eating too much protein can help.

If you have diabetes, your blood glucose, or blood sugar, levels are too high. Over time, this can damage your kidneys. Your kidneys clean your blood. If they are damaged, waste and fluids build up in your blood instead of leaving your body.

Kidney damage from diabetes is called diabetic nephropathy. It begins long before you have symptoms. People with diabetes should get regular screenings for kidney disease. Tests include a urine test to detect protein in your urine and a blood test to show how well your kidneys are working.

Continue reading “Diabetic Nephropathy | Diabetic Kidney Disease” »

For older adults with mild high blood pressure, a new study suggests consuming tomatoes may help manage hypertension and may even lower the risk of developing high blood pressure in the first place.

In the study, people without high blood pressure who ate the most tomatoes or tomato-based foods had a 36% lower risk of developing hypertension than those who ate the least.

In people who already had high blood pressure, especially those with stage 1 hypertension, moderate consumption of tomatoes was associated with a reduction in blood pressure.

This is good news potentially. TL1A have the potential of helping with inflammatory bowel disease, and arthritis and inflammatory diseases but it won’t come out, until half a decade from now.

Biotech stock investors are hoping for a repeat performance from the suite of TL1A drugs.

Proving The Drug’s Merit

Continue reading “There’s A Paradigm Shift In Immunology; And Big Pharma Is Paying Richly For It” »

The repair of damage to genetic material (DNA) in the human body is carried out by highly efficient mechanisms that have not yet been fully researched. A scientific team led by Christian Seiser from MedUni Vienna’s Center for Anatomy and Cell Biology has now discovered a previously unrecognized control point for these processes.

This discovery could lead to a new approach for the development of cancer therapies aimed at inhibiting the repair of damaged cancer cells. The research work was recently published in the journal Nucleic Acids Research.

GSE1-CoREST is the name of the newly discovered complex that contains three enzymes that control DNA repair processes and could form the basis for novel cancer therapeutics. “In research, these proteins are already associated with cancer, but not in the context that we have now found,” emphasizes Seiser, who led the study in close collaboration with researchers from the Max Perutz Labs Vienna.

With depression affecting around 1 in 10 of us at some point during our lives, the need for new and improved treatments is a top priority for researchers – and it appears that spinal cord stimulation could be one route for experts to investigate.

A team led by researchers at the University of Cincinnati College of Medicine devised a pilot clinical trial in which a little black box was placed on the spinal cord of 20 volunteers with depression, with one electrode on the back and one on the right shoulder.

The box then delivered a specially customized, low-level electric buzz to half of the volunteers, for three sessions per week over eight weeks. This was shown to have a greater effect on depressive symptoms than the different, ‘placebo’ charge administered to the other half of the volunteers.

Hospitals in four states, as well as Washington D.C., have brought in some form of mask-wearing requirements amid an uptick in cases.

Discovery could be useful in developing new therapies for multiple sclerosis, neurodegenerative conditions, and brain cancer.

New research from Oregon Health & Science University for the first time reveals the function of a little-understood junction between cells in the brain that could have important treatment implications for conditions ranging from multiple sclerosis to Alzheimer’s disease, to a type of brain cancer known as glioma.

The study will be published today (January 12) in the journal Nature Neuroscience.

Department of Energy user facility helps probe questions from changes in the structure of nuclei to nuclear reactions that shape the Universe.

The Facility for Rare Isotope Beams (FRIB) enables discoveries in the science of atomic nuclei, their role in the cosmos, and the fundamental symmetries of nature. This accelerator facility uses beams of short-lived nuclei not available elsewhere. Results from FRIB address questions such as the limits of the nuclear chart, the origin of the elements, and the reason for why there is more matter than antimatter in our Universe.

In FRIB’s first year, its measurements tackled the changes in the structure of the shortest-lived nuclei, exotic decay modes, nuclear reactions that affect cosmic events such as X-ray bursts, and processes in the crusts of neutron stars.