Laura Trachsel-Moncho, Anne Simonsen and colleagues (Universitetet i Oslo (UiO)) identify the endosomal protein SNX10 as a modulator of piecemeal mitophagy of OXPHOS machinery components and mitochondrial homeostasis. They show that loss of SNX10 enhances mitochondrial protein degradation, reduces respiration, and increases ROS levels, leading to elevated cell death in vivo.

Trachsel-Moncho et al.

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