Lifeboat Foundation

This isn’t rocket science it’s neuroscience.

Ever since the dawn of antiquity, people have strived to improve their cognitive abilities. From the advent of the wheel to the development of artificial intelligence, technology has had a profound leverage on civilization. Cognitive enhancement or augmentation of brain functions has become a trending topic both in academic and public debates in improving physical and mental abilities. The last years have seen a plethora of suggestions for boosting cognitive functions and biochemical, physical, and behavioral strategies are being explored in the field of cognitive enhancement. Despite expansion of behavioral and biochemical approaches, various physical strategies are known to boost mental abilities in diseased and healthy individuals. Clinical applications of neuroscience technologies offer alternatives to pharmaceutical approaches and devices for diseases that have been fatal, so far. Importantly, the distinctive aspect of these technologies, which shapes their existing and anticipated participation in brain augmentations, is used to compare and contrast them. As a preview of the next two decades of progress in brain augmentation, this article presents a plausible estimation of the many neuroscience technologies, their virtues, demerits, and applications. The review also focuses on the ethical implications and challenges linked to modern neuroscientific technology. There are times when it looks as if ethics discussions are more concerned with the hypothetical than with the factual. We conclude by providing recommendations for potential future studies and development areas, taking into account future advancements in neuroscience innovation for brain enhancement, analyzing historical patterns, considering neuroethics and looking at other related forecasts.

Keywords: brain 2025, brain machine interface, deep brain stimulation, ethics, non-invasive and invasive brain stimulation.

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The authors of a recent review published in Ageing Research Reviews summarize the research on epigenetic reprogramming and its potential as a rejuvenation therapy [1].

Aging leads to changes in the epigenome. Those changes can lead to alterations in gene regulation, affecting cellular homeostasis, and can play a role in age-associated phenotypes. Epigenetic modifications, the addition or removal of chemical groups to the DNA or DNA-associated proteins, have a profound impact on gene expression, tissue functions, and identity [2].

This review’s authors believe epigenetic reprogramming to be among the most currently promising interventions to stop or delay aging, potentially even reversing it at the cellular level. They believe that epigenetics are the basis of aging; therefore, being able to impact the epigenome would allow them to address multiple Hallmarks of Aging simultaneously.

Semiconductor devices are small components that manage the movement of electrons in contemporary electronic gadgets. They are essential for powering a wide range of high-tech products, including cell phones, laptops, and vehicle sensors, as well as cutting-edge medical devices. However, the presence of material impurities or variations in temperature can interfere with electron flow, causing instability.

But now, theoretical and experimental physicists from the Würzburg-Dresden Cluster of Excellence ct.qmat—Complexity and Topology in Quantum Matter have developed a semiconductor device from aluminum-gallium-arsenide (AlGaAs). This device’s electron flow, usually susceptible to interference, is safeguarded by a topological quantum phenomenon. This groundbreaking research was recently detailed in the esteemed journal Nature Physics.

“Thanks to the topological skin effect, all of the currents between the different contacts on the quantum semiconductor are unaffected by impurities or other external perturbations. This makes topological devices increasingly appealing for the semiconductor industry. They eliminate the need for the extremely high levels of material purity that currently drive up the costs of electronics manufacturing,” explains Professor Jeroen van den Brink, director of the Institute for Theoretical Solid State Physics at the Leibniz Institute for Solid State and Materials Research in Dresden (IFW) and a principal investigator of ct.qmat.

Human telomerase threatens genome integrity by adding telomeres to broken chromosomes and is held in check by ATR kinase signaling.

A revolutionary nanomaterial with huge potential to tackle multiple global challenges could be developed further without acute risk to human health, research suggests. The study is published in the journal Nature Nanotechnology.

Carefully controlled inhalation of a specific type of graphene—the world’s thinnest, super strong and super flexible material —has no short-term adverse effects on lung or cardiovascular function, the study shows. The first controlled exposure clinical trial in people was carried out using thin, ultra-pure graphene oxide—a water-compatible form of the material.

Researchers say further work is needed to find out whether higher doses of this graphene oxide material or other forms of graphene would have a different effect. The team is also keen to establish whether longer exposure to the material, which is thousands of times thinner than a human hair, would carry additional health risks.

A tiny robot with a clutch that mimics similar mechanisms found in microorganisms could be used to trigger the internal workings of a cell.

By Alex Wilkins

A groundbreaking titanium metamaterial with unparalleled strength and versatility could revolutionize manufacturing and high-speed aviation.

A lightweight, high-strength titanium material has been engineered that could lead to stronger medical devices and innovative vehicle and spacecraft designs. The research team used a common titanium alloy, Ti-6Al-4V, to construct the “metamaterial”, a term used to describe an artificial material that possesses unique properties not observed in nature — meta means “beyond” in Greek.

Many such intricate and surprisingly strong structures do exist in nature, like that of the Victoria water lily. Native to South America, this gigantic floating leaf is strong enough to support an adult owing to the unique lattice structure of it veins.

One of the ways cells in different kinds of tissue communicate is by exchanging RNA molecules. In experiments with roundworms of the species Caenorhabditis elegans, researchers at the State University of Campinas (UNICAMP) in Brazil found that when this communication pathway is dysregulated, the organism’s lifespan is shortened.

An article on the study is published in the journal Gene. The findings contribute to a better understanding of the aging process and associated diseases.

“Previous research showed that some types of RNA can be transferred from one cell to another, mediating intertissue communication, of the kind that occurs with proteins and metabolites, for example. This is considered a mechanism for signaling between organs or neighboring cells. It’s part [of the physiopathology] of several diseases and of the organism’s normal functioning,” said Marcelo Mori, corresponding author of the article and a professor at the Institute of Biology (IB-UNICAMP).

In a study published last month in mSystems, researchers from Osaka University revealed that the interaction between two common types of oral bacteria leads to the production of a chemical compound that is a major cause of smelly breath.

Bad breath is caused by volatile compounds that are produced when bacteria in the mouth digest substances like blood and food particles. One of the smelliest of these compounds is methyl mercaptan (CH₃SH), which is produced by microbes that live around the teeth and on the surface of the tongue. However, little is known about which specific bacterial species are involved in this process.

“Most previous studies investigating CH₃SH-producing oral bacteria have used isolated enzymes or relatively small culture volumes,” explains lead author of the study Takeshi Hara. “In this study, we aimed to create a more realistic environment in which to investigate CH₃SH production by major oral bacteria.”