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We have talked about the polarization of macrophages in a number of previous articles, but, in short, macrophages can have multiple behavioral profiles that determine what roles they play; this is known as polarization. A new study has identified a regulatory protein that controls this process.

Macrophage Polarization

For the purposes of this article, we are interested in the M1 and M2 polarization. The M1 type is pro-inflammatory and aggressive towards invading pathogens, while the M2 type of macrophage is anti-inflammatory in nature, suppressing inflammatory responses and facilitating tissue repair.

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If you’re one of the unlucky millions of people burdened by allergies, you know that sometimes there’s only so much antihistamines can do to help.

Researchers have been working to find more effective allergy treatments, and now they’ve discovered how a particular antibody can stop an allergic reaction from happening altogether.

An allergic reaction is the immune system’s way of completely overreacting to a normally benign substance, from proteins in cat saliva to surprisingly deadly peanuts.

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This revolutionary gene modified T cell therapy is bearing fruit in treating a type of lymphoma, a resistant form of cancer.


Summary: After years of effort, this revolutionary gene-modified T cell therapy is bearing fruit in treating a type of lymphoma, a resistant form of cancer. [This article first appeared on the website LongevityFacts.com. Author: Brady Hartman. ]

Thirty-seven-year-old Nick Asoian of Denver unsuccessfully fought Hodgkin’s Lymphoma using conventional cancer treatments for two years. In 2008, while in New Zealand for a ski race, Nick was diagnosed with Hodgkin’s Lymphoma. Two bone marrow transplants and two years of chemotherapy combined with radiation therapy didn’t bring his cancer to heel.

Then, a few years ago the avid skier got wind of clinical trial using T cell therapy at the Center for Cell and Gene Therapy at the Baylor College of Medicine in Texas. After speaking with Dr. Bollard and Vicky Torrano, the physicians conducting the trial, Asoian decided to give it a shot.

By Ben Hirschler

LONDON (Reuters) — Chinese scientists have cloned monkeys using the same technique that produced Dolly the sheep two decades ago, breaking a technical barrier that could open the door to copying humans.

Zhong Zhong and Hua Hua, two identical long-tailed macaques, were born eight and six weeks ago, making them the first primates — the order of mammals that includes monkeys, apes and humans — to be cloned from a non-embryonic cell.

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The ocean is crowded. As many as 10 million viruses can be found squirming in a single millilitre of its water, and it turns out they have friends we never even knew about.

Scientists have discovered a previously unknown family of viruses that dominate the ocean and can’t be detected by standard lab tests. Researchers suspect this viral multitude may already exist outside the water — maybe even inside us.

“We don’t think it’s ocean-specific at all,” says environmental microbiologist Martin Polz from MIT.

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Einstein’s secret to an incredibly intelligent brain may be in part to how well his brain aged…

Samples of his brain revealed he was missing a protein Lipofuscin, a not so well understood compound which contains lipid residues of lysosomal digestion that accumulates in the brain liver kidney, heart muscle, retina, adrenals, nerve cells, and ganglion cells.

Lipofuscin busting drugs could have a lot of potential for anti-aging therapies for the future.

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