Lifeboat Foundation: Safeguarding Humanity
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Category: biotech/medical – Page 2,497

A new interview on LEAF with biogerontologist Dr. João Pedro de Magalhães.

Today, we have an interview with Dr. João Pedro de Magalhães, the biogerontologist who created and runs senescence.info. In the unlikely event that his name is new to you, we had another interview with him last year, which you can check out here.

How do you think we age; are we programmed to die, do we wear out, or is the truth a mixture of both?

I don’t think we wear out. Humans and complex animals are made of cells and molecules that, by and large, have some turnover; we can replace most of our components, so I don’t think it’s correct to see aging as wearing out, at least not in complex animals like humans. (Please see here.) That said, I do think that some forms of cumulative damage contribute to the aging process, such as DNA damage. I also think that there are programmatic aspects to aging. That is, I think that genetic programs coordinating some aspects of growth and development persist into adulthood and become detrimental as forms of antagonistic pleiotropy. It is probably a combination of molecular damage and the inadvertent actions of genetic programs that causes aging.

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Published in Scientific Reports, this study is the first to provide evidence of new neuron formation—and the presence of stem cells—in the leopard gecko brain.

University of Guelph researchers have discovered the type of stem cell allowing geckos to create new brain cells, providing evidence that the lizards may also be able to regenerate parts of the brain after injury.

This finding could help in replacing human brain cells lost or damaged due to injury, aging or disease.

“The brain is a complex organ and there are so few good treatments for brain injury, so this is a very exciting area of research,” said Prof. Matthew Vickaryous in the Department of Biomedical Sciences at the Ontario Veterinary College (OVC).

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Billed as the Chinese answer to Dallas Buyers Club, the tear-jerking film Dying to Survive last week became Premier Li Keqiang’s new rallying cry for speeding up price cuts for cancer medications. It is an issue of such complexity that he has held two cabinet meetings about it in the past three months.

Li Keqiang has been trying to speed up price cuts for life-saving medication for months, and it’s a boon that the box-office hit has generated widespread awareness.

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Closing in on molecular manufacturing…

http://xt-pl.com received an honorable mention from I-Zone judges for its innovative product that prints extremely fine film structures using nanomaterials. XTPL’s interdisciplinary team is developing and commercializing an innovative technology that enables ultra-precise printing of electrodes up to several hundred times thinner than a human hair – conducive lines as thin as 100 nm. XTPL is facilitating the production of a new generation of transparent conductive films (TCFs) that are widely used in manufacturing. XTPL’s solution has a potentially disruptive technology in the production of displays, monitors, touchscreens, printed electronics, wearable electronics, smart packaging, automotive, medical devices, photovoltaic cells, biosensors, and anti-counterfeiting. The technology is also applicable to the open-defect repair industry (the repair of broken metallic connections in thin film electronic circuits) and offers cost-effective, non-toxic, flexible industry-adapted solutions.

XTPL’s technology might be the only one in the world offering cost-effective, non-toxic, flexible, industry adapted solution for the market of displays TFT/LCD/OLED, integrated circuits (IC), printed circuit boards (PCB), multichip modules (MCM); photolithographic masks & solar cells market.

XTPL delivers also solutions for research & prototyping including printing head, electronics, software algorithms which are the core of the system driving the electric field and the assembly process of nanoparticles implemented in XTPL’s Nanometric Lab Printer. It is a device that offers necessary functionalities to test, evaluate and use XTPL line-forming technology with nanometric precision and enables positioning of the printing head with micrometric resolution precisely.

Official video explaining XTPL’s technology: https://youtu.be/WMerzxzCXuw

Filmed at the I-Zone demo and prototype area at SID Display Week, the world’s largest and best exhibition for electronic information display technology.

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Consumer genetic testing company 23andMe announced on Wednesday that GlaxoSmithKline purchased a $300 million stake in the company, allowing the pharmaceutical giant to use 23andMe’s trove of genetic data to develop new drugs — and raising new privacy concerns for consumers.

23andMe is partnering with big pharma company GlaxoSmithKline. Here’s what that means for consumer rights and genetic privacy.

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While the rest of the world debates the ethics of designer babies, a team at the University of Massachusetts Medical School (UMass) have shown that we might not need CRISPR to change the genes of future generations. Their paper, released this week in the journal Developmental Cell, shows that things like diet and stress might affect some crucial genetic components of sperm, and that these tiny changes have real effects on how babies develop.

The same way rockets bound for outer space contain “payloads” like satellites, or astronauts who battle giant balls of urine, sperm are also like little rockets containing their own cargo: “small RNAs.” This study found that not only do RNA sequences play a crucial role in how genes get expressed early on in human development, but they can also be radically changed by the lifestyles of fathers. Things like diet, and in particular, stress can change the makeup of this crucial RNA cargo and lead to observable changes in offspring, says researcher Colin Conine, Ph.D., at UMass Medical School’s Rando Lab.

“Labs all over the world have been able to link changes in dad’s lifestyle to changes in RNA in the sperm, and then that leads to phenotypes in the offspring,” Conine tells Inverse. “Our study was one of the first to really look at how changes small RNAs affect early development. We wanted to ask, what are the first steps that lead to these phenotypes down the road?”

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Healthcare can be transformed with the innovation and insights of AI and machine learning. From robot-assisted surgery to virtual nursing assistants, diagnosing conditions facilitating workflow and analyzing images, AI and machines can help improve outcomes for patients and lower costs for providers.

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