Lifeboat Foundation

Scientists have discovered an antibody produced by an HIV-positive patient that neutralises 98 percent of all HIV strains tested — including most of the strains that are resistant to other antibodies of the same class.

Due to HIV’s ability to rapidly respond to the body’s immune defences, an antibody that can block a wide range of strains has been very hard to come by. But now that we’ve found one, it could form the basis of a new vaccine against the virus.

Researchers from the US National Institutes of Health (NIH) found that the antibody, called NG, was able to maintain its ability to recognise the HIV virus, even as the virus morphed and broke away from it.

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Lenses with a surface accuracy in the nanometer range are behind ever more accurate laser and optical systems. Manufacturers depend on ultra-precise optical and mechanical ablation processes, innovative coating processes and extremely accurate measuring technology to venture into these nano-worlds. The latest trends in optical manufacturing will be showcased by the world’s leading trade fair LASER World of PHOTONICS, from June 26–29, 2017 in Munich.

Nanoscribe GmbH’s 3D printing process creates three-dimensional micro and nano lenses from photosensitive coatings. The structures are built up a pulse at a time by highly focused femtosecond lasers employing two-photon polymerization. Source: Nanoscribe GmbH

The diversity of lenses, their shapes, sizes and materials is growing all the time. Applications in non-visible wavelengths from x-rays and ultraviolet to the far infrared also require special optics, such as material processing using short pulse and ultrashort pulse lasers or imaging techniques in the medical and research fields and industrial quality control.

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A team of scientists in China has become the first to treat a human patient with the groundbreaking CRISPR-Cas9 gene-editing technique. While the results of the trial are uncertain, it’s a historic milestone that should serve as a serious wakeup call to the rest of the world.

(Phys.org)—A team of researchers working at West China Hospital in Chengdu has for the first time injected CRISPR–Cas9 edited cells into a human test subject. Nature reports that the procedure occurred on October 28, and that thus far, the patient is doing “fine.”

Modified cells have been injected into human subjects before, of course, but using different techniques. CRISPR-Cas 9 is considered to be a more efficient approach. In this new effort, the researchers isolated immune cells retrieved from a blood sample, then used CRISPR-Cas9 to locate and disable the PD-1 protein in them, which prior research has shown slows an immune response by a cell. The idea is that disabling the protein will allow the immune system to put up more of a fight against tumor growth. The edited cells were placed in a container where they were fed and allowed to multiply—the entire collection was then gathered and injected into a patient suffering from a type of lung cancer that had not responded to any other treatment type.

The CRISPR technique involves using an RNA guide that binds to a particular DNA sequence and an enzyme (the Cas9 part) that can cut strands of DNA at preselected spots, allowing for removing strands or adding new ones.

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Scientists have discovered a new way to edit DNA that could fix “broken genes” in the brain, cure previously incurable diseases and potentially even extend the human lifespan.

The breakthrough – described as a “holy grail” of genetics – was used to partially restore the sight of rats blinded by a condition which also affects humans.

Previously researchers were not able to make changes to DNA in eye, brain, heart and liver tissues.

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Progress for heart disease!

For the first time, a new drug given along with a cholesterol-lowering statin medicine has proved able to shrink plaque that is clogging arteries, potentially giving a way to undo some of the damage of heart disease.

The difference was very small but doctors hope it will grow with longer treatment, and any reversal or stabilization of disease would be a win for patients and a long-sought goal.

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Great to see more quality aging biomarkers arriving for researchers. Well done to Alex Zhavoronkov and his team for this brilliant work.

Pathway analysis aids interpretation of large-scale gene expression data, but existing algorithms fall short of providing robust pathway identification.

I said over a year ago that if the US will not do it China will. Whilst there was talk about a moratorium on CRISPR in the US the Chinese were forging ahead and taking steps to become a world leader in biotech. Well here we are, they have deployed CRISPR in humans for cancer and this is only the start. As George Church advocates, we should have appropriate engineering safety measures in place but we should push ahead and do these things.

The move by Chinese scientists could spark a biomedical duel between China and the United States.

Fancy a bit of cheese?

(Medical Xpress)—A large team of researchers with members from several Europeans countries and the U.S. has found that mice fed a compound called spermidine lived longer than ordinary mice and also had better cardiovascular heath. In their paper published in the journal Nature Medicine, the researchers describe experiments they carried out with the compound and mice, what they found and why they believe the compound might provide benefits for humans.

Prior research has found that ingestion of spermidine—which was first discovered in semen samples, hence its name—led to longer lifespans in simple organisms such as fruit flies, yeast and roundworms. In this new study, the researchers sought to find out if the same would prove true for more complex creatures.

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