The eyes are a window into our deeper health.
As the only outward extension of the central nervous system, these sensory organs may reflect not only the state of our brain and blood vessels, but also our very bones.
Population studies in Singapore and the UK have now revealed that a person’s risk of osteoporosis may be associated with how quickly their eyes are aging.
Scientists in South Korea have developed experimental contact lenses designed to send electrical signals through the retina and into brain regions linked to mood. In mice, the technology appeared to improve depression-like behaviour.
The idea sounds futuristic: a contact lens that could one day help treat depression by stimulating the brain through the eye. The work is still at a very early stage, with findings so far limited to a single mouse study.
The eye is already one of the body’s most useful access points for medical technology.
Isomorphic Labs announces it has raised $2.1 Billion in Series B funding. The financing round is led by Thrive Capital, and includes participation from existing backers Alphabet and GV alongside new investors MGX, Temasek, CapitalG, and the UK Sovereign AI Fund, significantly expanding Isomorphic Labs’ global capital base.
Isomorphic Labs was founded with the ambition to leverage the power of AI to reimagine and accelerate drug discovery to bring much-needed treatments to millions of patients globally. The company aims to apply its pioneering AI drug design engine (IsoDDE) to deliver biomedical breakthroughs and is advancing drug design programs across multiple therapeutic areas and drug modalities.
Read more in the news release below.
An extremely interesting new technology which combines bacterial retrons with CRISPR-Cas for localized generation of single-stranded DNA inserts and subsequent targeted genome editing. I remember reading about retrons as an obscure biological phenomenon years ago in a monograph called Mobile DNA III, so it’s awesome to see them leveraged in this way!
A metagenomic screen identifies retron reverse transcriptases for precise genome-editing applications.
The causes of male infertility can be hard to diagnose, with many tests failing to detect genetic defects. Sometimes, infertility doesn’t even involve the genes themselves. It can arise from improper folding of the father’s DNA in the sperm. If a couple conceives, this mispackaged DNA can damage the lifelong health of the child.
“Paternal health is critical to sperm quality and the health of the offspring,” said Satoshi Namekawa, a professor of microbiology and molecular genetics. “Understanding the packing and folding of DNA in sperm cells is a fundamental question in modern biology.”
Namekawa and Ph.D. student Yu-Han Yeh have now unveiled an important new piece of this puzzle. They have identified a protein, called DAXX, that guides how sperm DNA is organized. DAXX silences thousands of genes so they don’t interfere with reproduction. It also keeps a handful of crucial genes turned on—shaping the delicate, early stages of embryonic development. The work was published recently in Genes & Development.
In 1985, the Innovative Design Fund placed an ad in Scientific American offering up to $10,000 to support clever prototypes for clothing, home decor, and textiles. William Freeman PhD ’92, then an electrical engineer at Polaroid and now an MIT professor, saw it and submitted a novel idea: a three-sided zipper. Instead of fastening pants, it’d be like a switch that seamlessly flips chairs, tents, and purses between soft and rigid states, making them easier to pack and put together.
Freeman’s blueprint was much like a regular zipper, except triangular. On each side, he nailed a belt to connect narrow wooden ‘teeth’ together. A slider wrapping around the device could be moved up to fasten the three strips into place, straightening them into a triangular tube. His proposal was rejected, but Freeman patented his prototype and stored it in his garage in the hopes it might come in handy one day.
Nearly 40 years later, MIT Computer Science and Artificial Intelligence Laboratory (CSAIL) researchers wanted to revive the project to create items with ‘tunable stiffness.’ Prior attempts to adjust that weren’t easily reversible or required manual assembly, so CSAIL built an automated design tool and adaptable fastener called the ‘Y-zipper.’ The scientists’ software program helps users customize three-sided zippers, which it then builds on its own in a 3D printer using plastics. These devices can be attached or embedded into camping equipment, medical gear, robots, and art installations for more convenient assembly.
A new system developed at MIT CSAIL helps users design three-sided fasteners called “Y-zippers,” then 3D prints them. The devices can be attached or embedded to camping equipment, medical gear, robots, and art installations, seamlessly switching each item between soft and rigid.
There’s something special about the APOE2 variant of the APOE (apolipoprotein E) gene: People who carry it tend to live longer, and they have a lower risk of developing Alzheimer’s disease.
Scientists are still trying to figure out why, and now, they have a new lead.
A team led by researchers at the Buck Institute for Research on Aging in the US set out to answer that question using human stem cell-derived neurons and mouse studies.
The emergence of effective immunotherapies has revolutionized therapies for many types of cancer. However, current immunotherapy has limited efficacy in certain patient populations and displays therapeutic resistance after a period of treatment. To address these challenges, a growing number of immunotherapy drugs have been investigated in clinical and preclinical applications. The diverse functionality of peptides has made them attractive as a therapeutic modality, and the global market for peptide-based therapeutics is witnessing significant growth. Peptides can act as immunotherapeutic agents for the treatment of many malignant cancers. However, a systematic understanding of the interactions between different peptides and the host’s immune system remains unclear.
