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• We Finally Know How to BOOST NITRIC OXIDE…
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Scientist Reveals How to BOOST NITRIC OXIDE to End Inflammation & REVERSE AGING! | Dr. William Li.
Most people think aging starts with wrinkles.
A little know fact is that mushrooms are a natural food to prevent disease especially in superbugs that keep getting stronger. This simple fact allows for better cheaper forms of natural defenses against viruses that can be almost out of control in some areas. Also they are cheaper to make than even antiviral medicines.
Mushrooms have long been celebrated for their culinary and medicinal properties. Species such as Ganoderma lucidum (Reishi) and Lentinula edodes (Shiitake) have been extensively used in traditional medicine for their immune-boosting and anti-inflammatory properties. Despite their well-documented nutritional and health benefits, the antimicrobial potential of mushrooms remains underexplored. Recent studies have shown that compounds like polysaccharides and phenolics found in mushrooms can effectively inhibit the growth of drug-resistant pathogens, including Methicillin-resistant Staphylococcus aureus (MRSA) and Candida albicans. For instance, Lentinula edodes extracts have demonstrated antibacterial activity against E. coli and antifungal properties against Candida species, highlighting their potential as a source of novel antimicrobial agents.
The combination drug ceftazidime-avibactam (CZA) is a last line of defense against the common Pseudomonas aeruginosa hospital bug: It’s the drug that gets called in when nothing else works, but there’s now evidence that it may not keep working for long.
Based on an analysis of two critically ill patients with P. aeruginosa infections, the bacteria are developin g genetic mutations that change the enzymes they produce – and can ward off an attack from CZA.
Researchers led by a team from Tongji University in China have now published a new paper in Microbiology Spectrum detailing the mutations and what it might mean for fighting P. aeruginosa in the future.
Cognitive frailty, characterized by the coexistence of physical frailty and cognitive impairment, has emerged as a major challenge in aging populations and is closely linked to sarcopenia, neurodegeneration, and chronic inflammation. Increasing evidence suggests that the gut microbiota acts as a central regulator of neuromuscular and neurocognitive aging through the integrated gut–brain–muscle axis. This review highlights how microbial dysbiosis, reduced short-chain fatty acid (SCFA) production, systemic endotoxemia, and altered microbial metabolites contribute to mitochondrial dysfunction, neuroinflammation, anabolic resistance, and impaired neuroplasticity.
Background Mitral valve prolapse (MVP) can be associated with ventricular arrhythmias (VA), but little is known about the relationship between VA and exercise in these patients. The aim of this study was to assess the occurrence and severity of VA during exercise tests in patients with MVP, and to explore the association between VA during exercise and the occurrence of arrhythmic events during follow-up.
Methods In this multicentre study, 375 patients with MVP (58 (48–69) years, 53% male) who underwent a clinically indicated exercise test were included. Severity of VA during exercise was defined as: no VA, minor VA (premature ventricular contractions ≥5% or non-sustained ventricular tachycardia (nsVT) 120 beats per minute) and major VA (nsVTs ≥120 beats per minute).
Results During exercise test, 242 (65%) patients showed no VA, 88 (24%) minor VA and 45 (12%) major VA.
Intraoperative motor mapping is essential for maximum safe resect ion of peri-Rolandic gliomas. While both awake and asleep techniques have demonstrated efficacy in preserving neurological function, comparative outcomes across WHO 2021 molecular tumor subtypes remain poorly defined. We compare outcomes between these mapping modalities in glioblastoma (GBM) and IDH-mutant gliomas.
A 130-patient cohort undergoing peri-Rolandic glioma resect ion with intraoperative motor mapping at a single institution was analyzed. Patients were stratified by mapping modality (awake n = 54, asleep n = 76) and tumor subtype (WHO 2021). Within the asleep cohort, handheld probe (HHP-DCS, n = 61) and subdural electrode direct cortical stimulation (SDE-DCS, n = 12) were compared. The primary outcome was new or worsening neurological deficits at 3 months. Secondary outcomes included Karnofsky Performance Status (KPS), hospital length of stay, discharge disposition, and survival in GBM patients.
Three-month deficit rates were comparable between awake and asleep mapping (5.6% vs. 5.3%, p = 1.000). In GBM patients, pre-and postoperative KPS were significantly lower in the asleep group (p 0.001 and p = 0.002), though delta KPS and 3-month deficit rates did not differ. No deficits occurred in either group among IDH-mutant gliomas. Progression-free and overall survival were comparable between mapping modalities in GBM. HHP-DCS and SDE-DCS produced similar 3-month deficit rates (3.3% vs. 16.7%, p = 0.124).
In this Review, Krishna and colleagues draw on clinical and scientific progress in the past two decades to describe the many factors that influence clinical outcomes during adoptive cell therapy using tumour-infiltrating lymphocytes and TCR-engineered T cell therapies. They explain how T cell-intrinsic factors and tumour-specific factors in patients with advanced cancer challenge or promote the success of adoptive cell transfer (ACT), and outline new approaches in the field of ACT.
Mongiovi, J.M., Babic, A., Sasamoto, N. et al. Ovarian cancer tumor immune profiles associated with intrauterine device and oral contraceptive use. Br J Cancer (2026). https://doi.org/10.1038/s41416-026-03508-9