Lifeboat Foundation: Safeguarding Humanity
Toggle light / dark theme

Blog

Category: biotech/medical – Page 225

Low-frequency wireless sensor tracks artery stiffening in real time with less interference

Wireless sensors used in wearable smart devices and medical equipment must be capable of detecting minute changes while maintaining high operational stability. However, existing technologies often utilize excessively high frequencies, leading to electromagnetic interference (EMI) or potential health risks to the human body. To address these fundamental issues, a Korean research team has developed a low-frequency-based wireless sensor technology.

A joint research team, led by Professor Seungyoung Ahn from the KAIST Cho Chun Shik Graduate School of Mobility and Professor Do Hwan Kim from the Department of Chemical Engineering at Hanyang University, has developed the “WiLECS” (Wireless Ionic-Electronic Coupling System), a low-frequency wireless electrochemical sensing platform that combines ion-based materials with wireless power transfer technology. The research is published in the journal Nature Communications.

Conventional wireless sensors suffer from low capacitance (the ability to store electrical charge), requiring high frequencies in the megahertz (MHz) range to compensate. However, these high-frequency methods can cause tissue heating or signal instability, limiting their practical application in clinical medical settings.

Pain-sensing neurons mapped in unprecedented detail, pointing to new chronic pain drug targets

One in five people worldwide suffers from chronic inflammatory pain. Meanwhile, about two thirds of those affected find little relief from existing pain medications; new therapeutic approaches are urgently needed. “We first must understand precisely how sensory nerve cells trigger pain at the molecular level—in other words, which proteins are involved,” says Professor Gary Lewin, Group Leader of the Molecular Physiology of Somatosensory Perception lab at the Max Delbrück Center in Berlin.

To unravel these molecular processes, Lewin—who has been studying pain for four decades and recently discovered a previously unknown ion channel involved in pain perception—is working closely with systems biologist Dr. Fabian Coscia, Group Leader of the Spatial Proteomics lab at the same center. Coscia co-developed a method called Deep Visual Proteomics that makes it possible to determine the proteome —the complete set of proteins—of specific cells and to create maps detailing the spatial locations of individual proteins.

The researchers combined this technology with electrophysiological methods from Lewin’s group. This enabled them to first identify specific subtypes of pain neurons based on their function and then analyze their protein profiles. The result is a high-resolution molecular map of these nerve cells, which has been published in Nature Communications. The team also demonstrated how the technology can identify potential new drug targets to treat chronic pain.

Designing better membrane proteins by embracing imperfection

Scientists at the VIB–VUB Center for Structural Biology have uncovered a counterintuitive principle that could reshape how membrane proteins are designed from scratch: Sometimes, making a protein less stable helps it fold correctly. In their study published in the Proceedings of the National Academy of Sciences, the researchers demonstrate that introducing carefully placed “imperfections,” a strategy known as negative design, enables synthetic membrane proteins to fold and assemble efficiently in artificial membranes.

Membrane proteins are essential for life and biotechnology, acting as gateways, sensors, and drug targets. Yet designing them from scratch remains notoriously difficult. Unlike soluble proteins, they must navigate a complex folding process while inserting into lipid membranes and during this step, many designs fail.

Traditional protein design focuses on maximizing the stability of the final folded structure. But the new study shows that, for transmembrane β-barrel proteins, this approach can backfire.

These nanotweezers grab thousands of tiny cell packets in seconds and expose their hidden cargo

Justus Ndukaife, associate professor of electrical and computer engineering and Chancellor Faculty Fellow, and his team have developed next generation nanotweezers that better analyze extracellular vesicles and aid in unraveling the mysteries of how cells package molecules and interact with one another. The research was published in Light: Science and Applications journal on March 20, 2026. Graduate student Ikjun Hong helped to perform the experimental characterization under Ndukaife’s direction.

Nanosized extracellular vesicles (EVs), though they vary in size and molecular cargo composition, are an important means for cells to communicate with each other. A significant research opportunity involves analyzing EVs individually to discern their biological roles in diverse diseases as well as leverage them for next generation therapeutics.

Studying single, intact EVs often relies on trapping individual particles, but existing methods face significant limitations. For example, optical tweezers —an approach recognized by the 2018 Nobel Prize in Physics—use a tightly focused laser beam to trap microscopic objects. However, the process is slow, as particles must be captured sequentially, and it is difficult to ensure that a new particle is trapped for each measurement. These constraints severely limit throughput and scalability.

Quantum sensors get a precision boost as 2D defects reveal their hidden timing

A key factor for the performance of sensors is the speed at which the system returns to its initial state after a disturbance or measurement, similar to the taring of a balance. In the quantum sensor under investigation, this corresponds to the transition of electrons from an energetically excited state to the ground state. However, the electrons remain in a kind of metastable intermediate state for a short time. A team of physicists from Julius-Maximilians-Universität Würzburg (JMU) has now directly measured this waiting time in a two-dimensional material: It lasts exactly 24 billionths of a second.

This knowledge is particularly important for quantum technology. It can be used to significantly increase the accuracy of atomic sensors, paving the way for the medical diagnostics of the future, for example. Professor Vladimir Dyakonov, Head of the Chair of Experimental Physics VI (EPVI), was responsible for the study published in the journal Science Advances.

Record-breaking photonics approach traps light on a chip for millions of cycles

For years, scientists have dreamed of using atomically thin van der Waals (vdW) materials to build faster, more efficient photonic chips. These materials can be stacked and tuned with extraordinary precision, opening possibilities far beyond those of conventional technologies. The challenge is that they are extremely fragile, making them notoriously difficult to shape with standard nanofabrication tools.

Now, an international team of researchers including scientists from Aalto University has overcome this long-standing barrier. By developing a method for what can be described as nanoscale surgery, they were able to sculpt these delicate materials without destroying them, achieving record-breaking performance in the process.

Published in Nature Materials, the work marks an important step forward for vdW materials, shifting them from passive coatings toward becoming the active building blocks of future photonic and quantum devices.

A New Chapter in Chemistry? Scientists Uncover New Way Metals Bind Oxygen

Iron plays a central role in how the body uses oxygen. In hemoglobin, it binds dioxygen, a pair of oxygen atoms, allowing blood to carry oxygen to tissues. But this is only part of the story. Iron-oxo compounds, which contain iron bonded to oxygen in a highly reactive form, also drive critical chemistry in the liver, where enzymes rely on them to break down medications and toxins.

Rice University chemist Raúl Hernández Sánchez set out to explore whether oxygen could react with other metals, particularly those in the lowest region of the periodic table known as the f-block. This group includes lanthanides in the upper row and actinides below.

He proposed that if lanthanides could bond with oxygen, they might form reactive lanthanide-oxo compounds. These compounds could serve as synthetic alternatives to iron-oxo systems and give chemists new ways to study small-molecule reactions linked to biology.

/* */