Researchers have developed a new two-photon fluorescence microscope that captures high-speed images of neural activity at cellular resolution. By imaging much faster and with less harm to brain tissue than traditional two-photon microscopy, the new approach could provide a clearer view of how neurons communicate in real time, leading to new insights into brain function and neurological diseases.
Scientists have made a groundbreaking advancement in understanding light propagation through complex media, potentially revolutionizing fields like optical communication and medical imaging.
By introducing the concept of coherence entropy, a new metric for evaluating light behavior, they have provided a reliable tool for managing light fields in challenging environments. This research could significantly enhance the performance of systems that rely on light, particularly in situations where traditional methods fail due to media distortion.
Light technology is at the heart of many cutting-edge innovations, from high-speed internet to advanced medical imaging. However, transmitting light through challenging environments, such as turbulent atmospheres or deformed optical systems, has always posed a significant hurdle. These complexities can distort and disrupt the light field, making it difficult to achieve clear and reliable results. Scientists have long sought ways to overcome these limitations, and a new breakthrough may hold the key to advance practical applications.
Researchers from Western University have discovered a protein that has the never-before-seen ability to stop DNA damage in its tracks. The finding could provide the foundation for developing everything from vaccines against cancer, to crops that can withstand the increasingly harsh growing conditions brought on by climate change.
Although natural-killer-cell therapies are safer than T-cell therapies and offer other advantages, they require upgrades to overcome their limited lifespan and susceptibility to immunosuppression.
ABOVE: Researchers recapitulate electrical gradients in vitro to help guide stem cell differentiation for neural regeneration. ©istock, Cappan.
The dance of development is electric. Bioelectrical gradients choreograph embryonic growth, signaling to stem cells what cell types they should become, where they should travel, who their neighbors should be, and what structures they should form.1 The intensity and location of these signals serve as an electrical scaffold to map out anatomical features and guide development. Bioelectricity also shapes tissue regeneration.2 Tapping into these mechanisms is of special interest to researchers who grapple with the challenge of regenerating injured nerves.3
One such curious team from Stanford University and the University of Arizona recently reported a new approach using electrically conductive hydrogels to induce differentiation of human mesenchymal stem cells into neurons and oligodendrocytes in vitro.4 Their findings, published in the Journal of Materials Chemistry B, provide important proof of principle for future studies of biocompatible materials to electrically augment transplanted and endogenous cells after injury.
Organoids of mammary glands can help researchers more efficiently study lactation, with findings that could apply to fields ranging from agriculture to medicine.
A tiny battery designed by MIT engineers could enable the deployment of cell-sized, autonomous robots for drug delivery within in the human body, as well as other applications such as locating leaks in gas pipelines.
The new battery, which is 0.1 millimeters long and 0.002 millimeters thick—roughly the thickness of a human hair—can capture oxygen from air and use it to oxidize zinc, creating a current of up to 1 volt. That is enough to power a small circuit, sensor, or actuator, the researchers showed.
“We think this is going to be very enabling for robotics,” says Michael Strano, the Carbon P. Dubbs Professor of Chemical Engineering at MIT and the senior author of the study. “We’re building robotic functions onto the battery and starting to put these components together into devices.”
“Not being able to communicate is so frustrating and demoralizing. It is like you are trapped,” Harrell said. “Something like this technology will help people back into life and society.”
For the researchers involved, seeing the impact of their work on Harrell’s life has been deeply rewarding. “It has been immensely rewarding to see Casey regain his ability to speak with his family and friends through this technology,” said the study’s lead author, Nicholas Card, a postdoctoral scholar in the UC Davis Department of Neurological Surgery.
Leigh Hochberg, a neurologist and neuroscientist involved in the BrainGate trial, praised Harrell and other participants for their contributions to this groundbreaking research. “Casey and our other BrainGate participants are truly extraordinary. They deserve tremendous credit for joining these early clinical trials,” Hochberg said. “They do this not because they’re hoping to gain any personal benefit, but to help us develop a system that will restore communication and mobility for other people with paralysis.”
This type of molecular collaboration has inspired scientists for nearly a century. Here, oxygen is the effector. It flips a protein switch, helping proteins better carry oxygen through the body. In other words, it may be possible to optimize protein functions with an alternative effector drug.
The problem? The original inspiration is wonky. Sometimes hemoglobin proteins carry oxygen. Other times they don’t. In 1965, a French and American collaboration found out why. Each protein alternates between two three-dimensional shapes—one that carries oxygen and another that doesn’t. The shapes can’t coexist in the assembled protein to carry oxygen: It’s all-or-none, depending on the presence and amount of the effector.
The new study built on these lessons to guide their AI-designed proteins.
Made by Cresilon, Traumagel can stop bleeding from gunshot wounds and is being looked at for future uses by the Department of Defense.
