Suming Huang & team show the HoxBlin c long non-coding RNA serves as an oncogenic regulator that controls 3D nuclear organization, chromatin accessibility and gene transcription related to leukemogenesis.
The figure shows H&E staining of sternum and spleen from WT and B-ALL HoxBlin c Tg mice.
1Division of Pediatric Hematology/Oncology, Department of Pediatrics, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA.
2Department of Molecular Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
3Genetics Branch, Center for Cancer Research, National Cancer Institute (NCI), NIH, Bethesda, Maryland, USA.