Lifeboat Foundation

Our mission is to promote the advancement of biomedical technologies which will increase healthy human lifespan.

A 5 year study. In recent years it has been shown to extend the lives of nematodes (or roundworms) by 57% and mice by 6%. In humans, claims abound that metformin-takers are living longer, having fewer cardiovascular episodes and seeing reduced odds of getting cancer.

Groundbreaking TAME trial, which directly targets aging as an endpoint, finally begins this November, reveals lead clinician Dr Nir Barzilai.

Physicists at LMU have developed a highly sensitive method for measuring the mechanical stability of protein conformations, and used it to monitor the early steps in the formation of blood clots.

As the central mediators of cell function in biological organisms, proteins are involved in the execution of virtually all cellular processes. They provide the internal scaffolding that gives cells their form, and enable cells to dynamically alter their morphology. They transport substrates back and forth across membranes, and they catalyze most of the chemical reactions that take place in cells. In the course of these tasks many proteins are subjected to external forces. Indeed, some “mechanosensitive” proteins effectively measure the strength of the forces acting upon them and are activated when the imposed force exceeds a given threshold value. Von Willebrand Factor (VWF), which initiates the formation of blood clots, is an important representative of this class.

The mechanical forces required to activate proteins like VWF are often so small that their magnitude could not be determined using existing methods. Now, a team of scientists led by LMU physicists Dr. Martin Benoit and Professor Jan Lipfert has developed a much more sensitive procedure. Their “magnetic tweezers” can quantify forces that are 100 times smaller than the commonly used alternative method currently available. As Lipfert and colleagues report in the journal PNAS, they have employed the technique to observe the unfolding of the VWF protein under the influence of low mechanical forces.

A series of genetic variants can influence handedness, according to a new paper.

No, researchers have not discovered a “handedness gene.” But through brain imaging of 9,000 people in the United Kingdom, researchers devised a list of genetic variations that contribute to the way different brain processes end up on either side of the brain. This, in turn influences handedness—and can also influence whether someone will develop certain neurological diseases, according to the paper published in the journal Brain.

Researchers at King Abdullah University of Science and Technology have recently developed a flexible and imperceptible magnetic skin that adds permanent magnetic properties to all surfaces to which it is applied. This artificial skin, presented in a paper published in Wiley’s Advanced Materials Technologies journal, could have numerous interesting applications. For instance, it could enable the development of more effective tools to aid people with disabilities, help biomedical professionals to monitor their patients’ vital signs, and pave the way for new consumer tech.

“Artificial skins are all about extending our senses or abilities,” Adbullah Almansouri, one of the researchers who carried out the study, told TechXplore. “A great challenge in their development, however, is that they should be imperceptible and comfortable to wear. This is very difficult to achieve reliably and durably, if we need stretchable electronics, batteries, substrates, antennas, sensors, wires, etc. We decided to remove all these delicate components from the skin itself and place them in a comfortable nearby location (i.e., inside of eye glasses or hidden in a fabric).”

The artificial skin, developed under the supervision of Prof. Jürgen Kosel, is magnetic, thin and highly flexible. When it is worn by a human user, it can be easily tracked by a nearby magnetic sensor. For instance, if a user wears it on his eyelid, it allows for his eye movements to be tracked; if worn on fingers, it can help to monitor a person’s physiological responses or even to control switches without touching them.

A joint study by researchers at the National Institutes of Health (NIH) and the University of Maryland (UMD) has revealed a previously undocumented protective function of the telomerase enzyme.

Telomerase is used by somatic cells too

It was thought for a long time that telomerase is only active in certain cell types, such as stem cells, immune cells, and embryonic cells, in order to protect them from aging. Aside from a few cell types and, of course, cancer cells, which are able to hijack the telomerase enzyme in order to replicate uncontrollably, researchers believed that the enzyme is switched off in other types of cells.

Providing a glimpse the hidden workings of evolution, a group of researchers at UC Santa Barbara have discovered that embryos that appear the same can start out with surprisingly different instructions.

“We found that a lot of undercover evolution occurs in early embryos,” said Joel Rothman, a professor in the Department of Molecular, Cellular, and Developmental Biology, who led the team.

Indeed, although members of the same species are identical across the vast majority of their genomes, including all the genetic instructions used in development, Rothman and his colleagues found that key parts of the assembly instructions used when embryos first start developing can differ dramatically between individuals of the same species.

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