Lifeboat Foundation: Safeguarding Humanity
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Category: biotech/medical – Page 1952

Treating prostate cancer through traditional means such as surgery or radiotherapy carries certain risks, with some patients experiencing impotence, urinary problems and bowel trouble, among other unwanted side effects. Safer and less invasive treatment options could soon be on the table, however, including a novel MRI-guided ultrasound technique that eliminated significant cancers in 80 percent of subjects in a year-long study.

The new technique is called MRI-guided transurethral ultrasound ablation (TULSA) and has been under development for a number of years. The minimally invasive technology involves a rod that enters the prostate gland via the urethra and emits highly controlled sound waves in order to heat and destroy diseased tissue, while leaving healthy tissue unharmed.

These waves come from 10 heating elements built into the length of the rod to treat the entire prostate gland. An algorithm controls which of these elements emit the sound waves at any one time, along with their shape, direction and strength. All of this takes place within an MRI scanner, allowing doctors to keep a close eye on which tissues are being heated and by how much.

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Up to 10% of global GDP could be stored on blockchains by 2025, according to the World Economic Forum. From product identifiers, medical records to land registries, academic degrees and insurance contracts, blockchain and distributed ledger technologies (DLTs) are already functioning in many sectors.

What blockchain promises is no less than the technological backbone of the 21st century’s renaissance of the social commons, giving back power to the people. In this century more than ever, power comes from data. Blockchain promises to give control of data back to the people. But this requires one element: trust in the technology, trust that it does what it’s supposed to do.

The paradox here is that blockchain removes the need to trust the intermediary – i.e., notaries, insurers and bankers – by requiring us to trust the technology. But how likely are we to trust the technology if it is breached repeatedly?

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The quest to live longer and healthier is not new. But the concept of reversing aging has recently stunned both the scienftific community and the public in general. Scientists have been able to reverse aging by 2.5 years to some participants in a groundbreaking experiment in the field of age reversal.

World leading scientists in the field of aging like David Sinclair think that aging is the ultimate disease that needs a cure. If scientsits were able to shed 2.5 years to the participants genomic age, the question raises itself, are we going to see an age reversal of a decade or more in the coming years?

#reverseaging #science #sciencetime

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Researchers with Stanford University have published a study revealing that physical aging is not a smooth process, but rather something that happens in what they describe as a ‘herky-jerky trajectory.’ Using blood tests to look at specific proteins, the researchers found that human aging involves three distinct turning points, the first starting in one’s mid-thirties.

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In back-to-back papers in the December 4 Science Translational Medicine, scientists led by Daniela Kaufer, University of California, Berkeley, and Alon Friedman, Ben-Gurion University of the Negev, Beer-Sheva, Israel, report that age-related cracks in the blood-brain barrier allow an influx of serum protein albumin into the brain, where they activate TGFβ receptors, overexcite neuronal networks, and impair cognition. Breaches correlated with localized slowing of cortical activity in epilepsy, Alzheimer’s disease patients, and in mouse models of AD. Called paroxysmal slow-wave events, these activity changes correlated with cognitive impairment and interspersed with seizures in epilepsy patients.

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Dmitry Kaminskiy speaks as though he were trying to unload everything he knows about the science and economics of longevity—from senolytics research that seeks to stop aging cells from spewing inflammatory proteins and other molecules to the trillion-dollar life extension industry that he and his colleagues are trying to foster—in one sitting.

At the heart of the discussion with Singularity Hub is the idea that artificial intelligence will be the engine that drives breakthroughs in how we approach healthcare and healthy aging—a concept with little traction even just five years ago.

“At that time, it was considered too futuristic that artificial intelligence and data science … might be more accurate compared to any hypothesis of human doctors,” said Kaminskiy, co-founder and managing partner at Deep Knowledge Ventures, an investment firm that is betting big on AI and longevity.

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Melanie Matheu is the CEO of Prellis Biologics. As a scientist, entrepreneur and somebody with a huge vision about the future of organ replacement this podcast literally asks what if we could print life from light. Laser-printing organs and vascular systems to give everybody another chance has incredible value. It changes the dynamics of how to handle endemic diseases like diabetes and many other organ issues, liver, kidney and maybe eventually very complex systems like the nervous systems inside our bodies. It’s a two-part podcast because the range of ideas and possibilities this brings up are almost infinite.

What if you could get life from light? Our guest today is doing exactly that. From laser printing of vascular elements to eventual full laser printing of organs from kidneys to livers and maybe eventually nervous systems, the ideas today are well within the grasp of reality in ten years’ time. Just imagine how this will change our medical systems, what doctors focus on and how we solve major global health crisis like diabetes. Imagine how it could give huge numbers of us a second, third or even fourth career as it expands life into the 80s, 90s and beyond.

Everybody who listens to these two podcasts will be affected directly or indirectly by the ideas Melanie is bringing to life. There is a very different to the future of organs, one that is far closer than we might have thought possible. That also means the questions and ideas about how we manage our bodies are going to change, very quickly.

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Last week, a woman named Victoria Gray became the first person in the U.S. to have her cells edited with CRISPR. The 41-year-old patient was suffering from sickle cell anemia.

RELATED: FIRST HUMAN TRIAL USING CRISPR GENE-EDITING IN US BEGINS

The condition, caused by a genetic mutation that messes with the shape of red blood cells, causes havoc on patients, and to make things even worse, the options for treatment are very limited and ineffective. The only current treatment for sickle cell anemia patients is a donor transplant that works for just 10% of patients, but all that is about to change.

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