Lifeboat Foundation

Background: The medical agent #MK615 is produced from #JapaneseApricot and contains a number of cyclic triterpenes. Antitumor activity of MK615 and its additive effect when combined with gemcitabine in pancreatic cancer cell line. MIAPaCa-2 was previously reported by our group. The objective of this phase I trial was to evaluate safety and feasibility of combined MK615 and gemcitabine therapy in patients with advanced or metastatic pancreatic cancer.

Conclusions: Combined MK615 and gemcitabine therapy was well-tolerated and showed antitumor activity in patients previously treated without gemcitabine or untreated patients with advanced or metastatic pancreatic cancer. Currently, we are planning phase II trials for elderly or frail people.

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Continue reading “A phase I fixed-dose feasibility study of MK615 and gemcitabine in patients with advanced or metastatic pancreatic cancer” »

A scientist from Harvard has used Ai to create a method for successfully predicting the folded shape of any protein. The work could have massive implications for the design and development of life-saving medicine.

Antibiotics have saved hundreds of millions of lives. But their continued, widespread use has led to mutated bacteria that are resistant to these drugs.

…from 2017/2018 that helped me understand the creation of Master Splinter.

Inserting human “mini-brains” into rodents has the potential to broaden scientists’ understanding of neurological disease, but raises quandaries about consciousness.

Arab American University congrats and is proud of Dr. Thabat Al-Khatib and researcher in Applied Neuroscience, Dr. Al-Khatib graduated from the Faculty of Sciences and Arts at Arab American University in 2012. She succeeded to add her name on the list of innovators in Britain after the invention of a drug treatment for Alzheimer’s disease and received two patents.

Al Khatib is currently working at the University of Aberdeen – Faculty of Medicine as a researcher in Neuroscience dept. and aspires to be a lecturer in Palestine to add value to students and the community.

Al-Khatib said commenting on the two inventions:

Continue reading “The University Is Proud and Congratulates Its Graduate Dr. Thabat Al-khatib and Researcher in Applied Neuroscience for Receiving Two Patents of Medicine for the Treatment of Alzheimer’s Disease” »

Biomedical pictures for April 2019.

Patients recovering from a stroke can slash their risk of blood clots by wearing a small “half wrist-watch” around their leg, a trial has shown.

A study at Royal Stoke University Hospital found the geko device could reduces the risk of clots compared to standard treatment, is comfortable to wear and could save the NHS cash.

Approved for use on the NHS for other conditions, the geko is a battery-powered, disposable, device designed to increase blood flow in the deep veins of the legs.

Continue reading “Small ‘half-watch’ worn on leg could transform recovery from stroke” »

In a proof-of-principle study in mice, scientists at Johns Hopkins Medicine report the creation of a specialized gel that acts like a lymph node to successfully activate and multiply cancer-fighting immune system T-cells. The work puts scientists a step closer, they say, to injecting such artificial lymph nodes into people and sparking T-cells to fight disease.

In the past few years, a wave of discoveries has advanced new techniques to use T-cells – a type of white blood cell – in cancer treatment. To be successful, the cells must be primed, or taught, to spot and react to molecular flags that dot the surfaces of cancer cells. The job of educating T-cells this way typically happens in lymph nodes, small, bean-shaped glands found all over the body that house T-cells. But in patients with cancer and immune system disorders, that learning process is faulty, or doesn’t happen.

To address such defects, current T-cell booster therapy requires physicians to remove T-cells from the blood of a patient with cancer and inject the cells back into the patient after either genetically engineering or activating the cells in a laboratory so they recognize cancer-linked molecular flags.

Continue reading “Scientists advance Creation of ‘Artificial Lymph node’ to fight Cancer, other diseases” »

A medical miracle happened about 170 years ago when scientists discovered general anesthesia that enables millions of patients to undergo invasive, life-saving surgeries without pain. However, in spite of decades of research, scientists cannot understand why general anesthesia works.

In a new study published online in Neuron, scientists believe they have discovered the part of the answer. A team of researchers from a Duke University found that several different general anesthesia drugs knock out the patient by hijacking the neural circuitry that the person falls asleep.

They traced this neural circuitry to a tiny cluster of cells at the base of the brain responsible for churning out hormones to regulate bodily functions, moods, and sleep. The discovery is one of the first to indicate a role for the hormones in maintaining the state of general anesthesia and provides valuable insights for generating newer drugs that could put people to sleep with fewer side effects.

Continue reading “Scientists Discovered Where Anesthesia Works On the Brain” »