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Category: biotech/medical – Page 180

Cells Use Lightning-Like Electricity to Kill Their Weakest Neighbors

Scientists have discovered that the protective cell layers lining our organs operate like an electrical surveillance system, using lightning-like flashes to identify and eliminate their most energy-depleted neighbors. This cellular quality control mechanism, revealed in a new Nature study, could reshape our understanding of diseases from cancer to stroke.

The research team from King’s College London and the Francis Crick Institute uncovered this process while studying epithelial cells – the tightly packed cellular barriers that line every organ in the human body. These cells constantly turnover to maintain healthy protective layers, but researchers had long puzzled over which specific cells get selected for elimination in crowded tissues.

Using specialized microscopy, the scientists noticed something unexpected: brief, lightning-like electrical flashes around cells just before they were squeezed out and died. This electrical signature, they discovered, wasn’t random but represented a sophisticated energy-sensing mechanism that targets the cellular equivalent of the weakest links.

New study sheds light on how exercise helps lose weight

Researchers have provided new insights into how exercise helps lose weight. They discovered a mechanism by which the compound Lac-Phe, which is produced during exercise, reduces appetite in mice, leading to weight loss. The findings appeared in Nature Metabolism.

“Regular exercise is considered a powerful way to lose weight and to protect from obesity-associated diseases, such as diabetes or heart conditions,” said co-corresponding author Dr. Yang He, assistant professor of pediatrics—neurology at Baylor and investigator at the Duncan NRI. “Exercise helps lose weight by increasing the amount of energy the body uses; however, it is likely that other mechanisms are also involved.”

The researchers previously discovered that Lac-Phe is the most increased metabolite—a product of the body’s metabolism—in blood after intense exercise, not just in mice but also in humans and racehorses. The team’s previous work showed that giving Lac-Phe to obese mice reduced how much they ate and helped them lose weight without . But until now, scientists didn’t fully understand how Lac-Phe works to suppress .

Researchers trace genetic code’s origins to early protein structures

Genes are the building blocks of life, and the genetic code provides the instructions for the complex processes that make organisms function. But how and why did it come to be the way it is?

A recent study from the University of Illinois Urbana-Champaign sheds new light on the origin and evolution of the , providing valuable insights for genetic engineering and bioinformatics. The study is published in the Journal of Molecular Biology.

“We find the origin of the genetic code mysteriously linked to the dipeptide composition of a proteome, the collective of proteins in an organism,” said corresponding author Gustavo Caetano-Anollés, professor in the Department of Crop Sciences, the Carl R. Woese Institute for Genomic Biology, and Biomedical and Translation Sciences of Carle Illinois College of Medicine at U. of I.

‘Virtual clinical trials’ may predict success of heart failure drugs

Mayo Clinic researchers have developed a new way to predict whether existing drugs could be repurposed to treat heart failure, one of the world’s most pressing health challenges. By combining advanced computer modeling with real-world patient data, the team has created “virtual clinical trials” that may facilitate the discovery of effective therapies while reducing the time, cost, and risk of failed studies.

“We’ve shown that with our framework, we can predict the clinical effect of a drug without a . We can say with high confidence if a drug is likely to succeed or not,” says Nansu Zong, Ph.D., a biomedical informatician at Mayo Clinic and lead author of the study, which was published in npj Digital Medicine.

New system dramatically speeds the search for polymer materials

MIT researchers developed a fully autonomous platform that can identify, mix, and characterize novel polymer blends until it finds the optimal blend. This system could streamline the design of new composite materials for sustainable biocatalysis, better batteries, cheaper solar panels, and safer drug-delivery materials.

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