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Category: biotech/medical – Page 1,340

Alzheimer’s disease biomarkers can predict postoperative delirium

Clinical studies have demonstrated a strong association between Alzheimer’s disease (AD) and delirium. A change to the Tau protein, which can lead to the formation of tangles in brain, is one of the hallmarks of AD pathology, and Tau phosphorylation at threonine 217 (Tau-PT217) and threonine 181 (Tau-PT181) are new plasma biomarkers that can detect early-stage AD. A clinical study led by investigators at Massachusetts General Hospital (MGH) has shown that plasma Tau-PT217 and Tau-PT181 are associated with incidence and severity of postoperative delirium. The findings are published in Annals of Surgery.

Early studies from the same research group at MGH have shown that the ratio of beta amyloid (which causes AD’s signature plaques) to Tau in cerebrospinal fluid is associated with . Recent studies in other labs have reported that plasma Tau-PT181 concentration distinguishes AD dementia from other neurological disorders. Plasma levels of Tau-PT217 are associated with the changes in levels of Tau-PT217 and AD development.

In this current study, the team at MGH developed a novel method to measure Tau-PT217 and Tau-PT181 concentrations in plasma of patients, called nanoneedle technology, in collaboration with NanoMosaic (Woburn, MA). “The nanoneedle technology is ultrasensitive, requires a small volume, and can measure low concentrations of molecules, including Tau-PT217 and Tau-PT181,” says lead author Feng Liang, MD, Ph.D., in the Department of Anesthesia, Critical Care and Pain Medicine at MGH. “More than 20,000 nanoneedles are integrated on a silicon substrate assigned to detect one analyte. Each nanoneedle is a single molecule biosensor functionalized with antibodies,” says Liang.

Researchers decode patterns that make our brains human

The human brain may be the most complex piece of organized matter in the known universe, but Allen Institute researchers have begun to unravel the genetic code underlying its function. Research published this month in Nature Neuroscience identified a surprisingly small set of molecular patterns that dominate gene expression in the human brain and appear to be common to all individuals, providing key insights into the core of the genetic code that makes our brains distinctly human.

“So much research focuses on the variations between individuals, but we turned that question on its head to ask, what makes us similar?” says Ed Lein, Ph.D., Investigator at the Allen Institute for Brain Science. “What is the conserved element among all of us that must give rise to our unique cognitive abilities and human traits?”

Researchers used data from the publicly available Allen Human Brain Atlas to investigate how gene expression varies across hundreds of functionally distinct brain regions in six human brains. They began by ranking genes by the consistency of their expression patterns across individuals, and then analyzed the relationship of these genes to one another and to brain function and association with disease.

The omicron subvariant now dominating the US is ‘the worst version of the virus that we’ve seen’

New immune-evading Omicron subvariant BA.5 is now dominant in the U.S.—and previous heavy hitter “stealth Omicron” is now a shadow of its former self, according to federal health data released Tuesday.

BA.5 is estimated to have caused nearly 54% of COVID infections in the U.S. last week, according to data from the U.S. Centers for Disease Control and Prevention. Along with twin variant BA.4, it swept South Africa this spring thanks to its ability to evade immunity from both prior infection and vaccination.

The week before that, the two variants combined made up slightly more than half of U.S. cases. But last week, BA.5 accomplished the same feat alone, without the help of BA.4, which came in third at 16.5%.

Miniature, Implantable Nerve Coolers for Targeted Pain Relief

Summary: Researchers have developed a new implantable device that can “cool” nerves and provide on-demand pain relief for those suffering from neuropathic or chronic pain.

Source: AAAS

An implantable device designed to “cool” nerves can provide targeted, on-demand pain relief, researchers report. When tested on rats with neuropathic pain, the device produced highly localized cooling.

Antibiotic Treatments May Make Us More Susceptible to Negative Emotions

Summary: Recent antibiotic use impacts the way in which people pay attention to negative facial expressions. Findings shed light on how antibiotic use can increase the risks of depression.

Source: Lieden University.

People who have taken antibiotics in the past three months pay more attention to negative facial expressions, according to research by postdoc Katerina Johnson and assistant professor Laura Steenbergen. This may explain how antibiotics increase the risk of developing depression.

New gene profiling technology reveals melanoma biomarkers

A new UC Davis-led study sheds light on cell type-specific biomarkers, or signs, of melanoma. The research was recently published in the Journal of Investigative Dermatology.

Melanoma, the deadliest of the common skin cancers, is curable with and treatment. However, diagnosing clinically and under the microscope can be complicated by what are called melanocytic nevi—otherwise known as birth marks or moles that are non-cancerous. The development of melanoma is a multi-step process where “melanocytes,” or the cells in the skin that contain melanin, mutate and proliferate. Properly identifying melanoma at an early stage is critical for improved survival.

“The biomarkers of early melanoma evolution and their origin within the tumor and its microenvironment are a potential key to early diagnosis of melanoma,” said corresponding author of the study Maija Kiuru, associate professor of clinical dermatology and pathology at UC Davis Health. “To unravel the mystery, we used high-plex spatial RNA profiling to capture distinct gene expression patterns across cell types during melanoma development. This approach allows studying the expression of hundreds or thousands of genes without disrupting the native architecture of the tumor.”

Neural prosthetics: Krishna Shenoy at TEDxStanford

Krishna Shenoy helps to restore lost function for disabled patients by designing prosthetic devices that can translate neural brain activity.

Krishna Shenoy directs the Neural Prosthetic Systems Lab, where his group conducts neuroscience and neuro-engineering research to better understand how the brain controls movement and to design medical systems to assist those with movement disabilities. Shenoy also co-directs the Neural Prosthetics Translational Lab, which uses these advances to help people with severe motor disabilities. Shenoy received his bachelor’s degree in electrical engineering from UC-Irvine and his master’s and doctoral degrees in the same field from MIT. He was a neurobiology postdoctoral fellow at Caltech in Pasadena and then joined Stanford University, where he is a professor of electrical engineering, bioengineering and neurobiology.

Scientists Create Programmable Nanoparticle Toothbrush

The basic design of the toothbrush hasn’t changed in a thousand years — sure, there are motors, different materials, and funky shapes, but they’re all still sticks with bristles attached. A team from the University of Pennsylvania believes it’s time to shake things up. In a new study, the researchers have shown that shapeshifting nanoparticles can successfully clean teeth, replacing all the manual labor with a nano-scale robotic dance. Not only can these particles be transformed into tooth-cleaning shapes, but their action can have antimicrobial effects that destroy plaque-causing bacteria.

This project came together quite by accident. A group from the Penn School of Dental Medicine under professor Hyun (Michel) Koo was interested in leveraging the catalytic activity of nanoparticles to release free radicals that could kill microbes on the teeth. Meanwhile, senior engineering researcher Edward Steagar was spearheading work at the Penn School of Engineering and Applied Sciences on assembling nanoparticles into robots. Bringing these projects together gave us the sci-fi gray goo toothbrush.

The combined team used magnetic fields to manipulate iron oxide nanoparticles, testing them first on a slab of tooth-like material. Next, the team moved to 3D-printed copies of teeth. Finally, they tested the nanoparticle brushes on real teeth that were mounted in a realistic way to simulate a human mouth. The tests show these nanoparticles can form brush-like shapes capable of scrubbing off the biofilms that lead to tooth decay. They can also flow between teeth like floss. All the while, the nanoparticles promote the production of free radicals that further eliminate bacteria.

Graphene tattoo provides cuffless blood pressure monitoring

Near-invisible graphene tattoos deliver high-speed and long-term continuous monitoring of blood pressure with high accuracy.

Wrapping a cuff around a patient’s arm and inflating it to measure blood pressure is one of the most routinely performed medical tests. It provides a quick and reliable assessment of cardiovascular health, as blood pressure is an independent predictor of all-cause mortality. But such arm cuffs are bulky and uncomfortable, making them impractical for continuous monitoring outside of clinics.

For this reason, researchers are developing cuffless alternatives with the goal of unlocking new possibilities for patient diagnostics and management, as well as providing new understanding of physiology. However, none of these tools has become a mainstay yet.

One option, acoustic sensors, slide during movements and are too large to be easily incorporated into untethered ambulatory sensors. Meanwhile, optical modalities such as smart watches are limited by the low penetration of light into tissues, which hinders their ability to capture haemodynamic parameters in the arteries. Studies also show that optical sensors are sometimes inaccurate when used with darker skin tones or larger wrists.

Shinzo Abe Attacker Tetsuyo Yamagami Used A 3D Printed Gun, Shot From 10 Feet. Chilling Details Emerge

Tokyo/New Delhi: Tetsuya Yamagami, who shot Shinzo Abe in Nara City, used a handmade gun to attack the former Japanese Prime Minister, said reports. The 41-year-old shooter, a resident of Nara City in Japan shot Abe in his chest from 10 feet away, said reports. For the unversed, Abe was shot during live address in Western Japan. The attack was a shock in one of the world’s safest countries with some of the strictest gun control laws. During interrogation, the attacker has confessed that he was dissatisfied with Abe.

NHK public broadcaster aired dramatic footage of Abe giving a speech outside of a train station in the western city of Nara. He is standing, dressed in a navy blue suit, raising his fist, when a gunshot is heard. Footage then shows Abe collapsed on the street, with security guards running toward him. He holds his chest, his shirt smeared with blood.

Second video shows the attempted assassination of former Japanese Prime Minister Shinzo Abe.