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The Thymus As A Key Target For Aging Intervention — Dr. Greg Fahy — EARD 2022

This is a followup trial result to the first trial that reported 2.5 years of epigenetic age reversal This has interesting reports from the actual patients about how they feel and the changes it made to them. After the first trial I sent an email to see if I could do this but I have IBS which Fahy said would disqualify me.


Dr. Greg Fahy gives an update on the TRIIM-X clinical trial at EARD 2022.

The TRIIM-X clinical trial aims to understand how to create a personalized thymus regeneration regimen. By regenerating the thymus, the researchers hope to be able to prevent or reverse certain aspects of immune system aging.

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Walking pneumonia: What does it mean?

Walking pneumonia is an informal term for pneumonia that isn’t severe enough to require bed rest or hospitalization. You may feel like you have a cold. The symptoms are generally so mild that you don’t feel you need to stay home from work or school, so you are out walking around.

Chances are you won’t see a doctor for your mild symptoms. If you do see a doctor, you may not seem sick enough to need a chest X-ray, which is the way to diagnose any kind of pneumonia.

Walking pneumonia is often caused by a type of bacterium that produces milder symptoms that come on more gradually than do those of other types of pneumonia. The illness often is brought home by young children who contract it at school. Family members of infected children typically begin having symptoms two or three weeks later. This kind of pneumonia can be treated with an antibiotic.

Methionine Restriction Extends Lifespan: Roles For SCFAs And FGF21, But Not Calorie Restriction

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World’s First Artificial Human Liver Grown In Lab

The world’s first artificial liver has been grown from stem cells by British scientists. The resulting “mini-liver” is the size of a small coin; the same technique will be further developed to create a full-size liver.

The mini-liver is useful as it is; within two years it can be used to test new drugs, reducing the number of animal experiments as well as providing results based on a human (rather than animal) liver.

Pancreas-on-a-Chip Technology for Transplantation Applications

Human pancreas-on-a-chip (PoC) technology is quickly advancing as a platform for complex in vitro modeling of islet physiology. This review summarizes the current progress and evaluates the possibility of using this technology for clinical islet transplantation.

PoC microfluidic platforms have mainly shown proof of principle for long-term culturing of islets to study islet function in a standardized format. Advancement in microfluidic design by using imaging-compatible biomaterials and biosensor technology might provide a novel future tool for predicting islet transplantation outcome. Progress in combining islets with other tissue types gives a possibility to study diabetic interventions in a minimal equivalent in vitro environment.

Although the field of PoC is still in its infancy, considerable progress in the development of functional systems has brought the technology on the verge of a general applicable tool that may be used to study islet quality and to replace animal testing in the development of diabetes interventions.

The Organ-on-a-Chip Revolution Is Here

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Not to mention the potential for cost-savings. If you have been severely sick, you will have felt the unfairness of the high cost of drugs. The latest drugs for cancer, cardiovascular or gastrointestinal diseases, nervous disorders, and rare conditions are so costly that even selling an expensive car won’t cover a year’s supply of them.

The most poignant example is that of cancer drugs, whose approval is by far the most wasteful process of all drug types: The FDA approves less than four percent of cancer drugs, meaning 96 percent of them spend more than a decade being tested in petri dishes, mice, and a small set of patients, before scientists finally realize that they aren’t suitable for human use. Each drug in the four percent that does get approved bears an average price tag of more than a billion dollars, a bill passed down to you, the patient-customer.

Given what is at stake, it is not surprising that a growing number of companies are offering their organs-on-chips to pharma, each with a different technology, patented chip design, or organ. The three oldest companies in this space — Hurel Corporation, Hepregen, and Organovo, founded in 2007 — are all from the United States. InSphero (Switzerland, 2009), TissUse (Germany, 2010), and Mimetas (Netherlands, 2011) were started shortly afterward. Nortis (Seattle, 2012) and Emulate (Boston, 2013, by Don Ingber) followed, and after them half a dozen startup companies are fighting to grow in this exciting cauldron. Thanks to the organs-on-chips pioneered by Grotberg, Huh, and Takayama, the day when most new drugs will be developed and tested directly (and only) using human tissues is fast approaching.

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