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Category: biotech/medical – Page 1,342

Chemotherapy could increase disease susceptibility in future generations

A common chemotherapy drug could carry a toxic inheritance for children and grandchildren of adolescent cancer survivors, Washington State University-led research indicates.

The study, published online in iScience, found that male rats who received the ifosfamide during adolescence had offspring and grand-offspring with increased incidence of disease. While other research has shown that cancer treatments can increase patients’ chance of developing disease later in life, this is one of the first-known studies showing that susceptibility can be passed down to a third generation of unexposed offspring.

“The findings suggest that if a patient receives , and then later has children, that their grandchildren, and even great-grandchildren, may have an increased disease susceptibility due to their ancestors’ chemotherapy exposure,” said Michael Skinner, a WSU biologist and corresponding author on the study.

How generative AI could create assets for the metaverse

Check out the on-demand sessions from the Low-Code/No-Code Summit to learn how to successfully innovate and achieve efficiency by upskilling and scaling citizen developers. Watch now.

The metaverse skyrocketed into our collective awareness during the height of the pandemic, when people longed for better ways to connect with each other than video calls. Gaming’s hot growth during the pandemic also pushed it forward. But the metaverse became so trendy that it now faces a backlash, and folks aren’t talking about it as much.

Yet technologies that will power the metaverse are speeding ahead. One of those technologies is generative AI, which uses deep learning neural networks to produce creative concept art and other ideas based on simple text prompts.

Highly integrated watch for noninvasive continual glucose monitoring

This article reports a highly integrated watch for noninvasive continual blood glucose monitoring. The watch employs a Nafion-coated flexible electrochemical sensor patch fixed on the watchband to obtain interstitial fluid (ISF) transdermally at the wrist. This reverse iontophoresis-based extraction method eliminates the pain and inconvenience that traditional fingerstick blood tests pose in diabetic patients’ lives, making continual blood glucose monitoring practical and easy. All electronic modules, including a rechargeable power source and other modules for signal processing and wireless transmission, are integrated onto a watch face-sized printed circuit board (PCB), enabling comfortable wearing of this continual glucose monitor. Real-time blood glucose levels are displayed on the LED screen of the watch and can also be checked with the smartphone user interface.

Apple Watch could gain long-sought glucose tracking with Rockley Photonics deal: report

Year 2021 face_with_colon_three

While the Apple Watch has evolved from a fashionable phone accessory to a high-tech health monitor—capable of scanning for heart conditions and calling for help after injuries—future generations may tap into a deeper set of features to track the body’s inner workings.

This could include long-rumored blood sugar readings, from the wrist-worn gadget, plus blood pressure measurements, hydration levels and more, following newly divulged arrangements with the sensor maker Rockley Photonics.

As first reported by The Daily Telegraph, Rockley now lists Apple as its biggest customer and contributor of the lion’s share—or potentially nearly all—of its revenues dating back to 2019.

The neural architecture of language: Integrative modeling converges on predictive processing

The neuroscience of perception has recently been revolutionized with an integrative modeling approach in which computation, brain function, and behavior are linked across many datasets and many computational models. By revealing trends across models, this approach yields novel insights into cognitive and neural mechanisms in the target domain. We here present a systematic study taking this approach to higher-level cognition: human language processing, our species’ signature cognitive skill. We find that the most powerful “transformer” models predict nearly 100% of explainable variance in neural responses to sentences and generalize across different datasets and imaging modalities (functional MRI and electrocorticography). Models’ neural fits (“brain score”) and fits to behavioral responses are both strongly correlated with model accuracy on the next-word prediction task (but not other language tasks). Model architecture appears to substantially contribute to neural fit. These results provide computationally explicit evidence that predictive processing fundamentally shapes the language comprehension mechanisms in the human brain.

The Friedmann equations, and how they are related to protests in China

NEW DELHI: Among all the protests that have erupted across China following the strict quarantine measures enforced by the government for Covid-19, one form that has stood out is the display of a physics equation.

In images widely being circulated on social media, students of Beijing’s Tsinghua University can be seen holding sheets on which is written one of the Friedmann equations.

What these equations have to do with the subject of the protests is open to speculation. Many on social media have suggested that it is a play on the words “free man”. Another view is that it symbolises a free and “open” China, because the Friedmann equations describe an “open” (expanding) universe.

Novel method automates the growth of brain tissue organoids on a chip

A team of engineers at UC Santa Cruz has developed a new method for remote automation of the growth of cerebral organoids—miniature, three-dimensional models of brain tissue grown from stem cells. Cerebral organoids allow researchers to study and engineer key functions of the human brain with a level of accuracy not possible with other models. This has implications for understanding brain development and the effects of pharmaceutical drugs for treating cancer or other diseases.

In a new study published in the journal Scientific Reports, researchers from the UCSC Braingeneers group detail their automated, internet-connected microfluidics system, called “Autoculture.” The system precisely delivers feeding liquid to individual in order to optimize their growth without the need for human interference with the .

Cerebral organoids require a high level of expertise and consistency to maintain the precise conditions for cell growth over weeks or months. Using an , as demonstrated in this study, can eliminate disturbance to cell culture growth caused by human interference or error, provide more robust results, and allow more scientists access to opportunities to conduct research with human brain models.

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