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Nectandrin B (Found In Nutmeg) Extends Lifespan As Much As Rapamycin

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Some patients could use special eyedrops instead of reading glasses as they age, researcher says

Everybody develops presbyopia as they age—a difficulty in focusing on near objects and text—and often must resort to reading glasses. However, the solution might be as simple as using special eye drops two or three times a day.

A retrospective study of 766 patients presented at the 43rd Congress of the European Society of Cataract and Refractive Surgeons (ESCRS) has found that the majority could read an extra two, three or more lines on the eye chart used for testing near visual acuity (the Jaeger chart) after using specially formulated eye drops. This improvement was sustained for up to two years.

Dr. Giovanna Benozzi, director of the Center for Advanced Research for Presbyopia, in Buenos Aires, Argentina, said, We conducted this research due to the significant unmet medical need in presbyopia management. Current solutions such as reading glasses or surgical interventions have limitations, including inconvenience, social discomfort, and potential risks or complications.

Unlocking the immune system’s instruction manual: How T follicular helper cells mount a flexible response

Scientists have uncovered how a key type of immune cell adapts its behavior depending on the type of infection, paving the way for better vaccines and advancing research into immune-related diseases.

In their study published in Nature Immunology, a WEHI-led research team has revealed how T follicular helper (Tfh) cells tailor their instructions to the depending on the pathogen they encounter.

The findings shed light on the molecular “instruction manual” that guides and long-term immunity, offering new tools to improve vaccine design and develop targeted therapies for immune-related conditions and other major health challenges, including cancer.

Visualization of blood flow sharpens artificial heart design

Using magnetic cameras, researchers at Linköping University have examined blood flow in an artificial heart in real time. The results make it possible to design the heart in a way to reduce the risk of blood clots and red blood cell breakdown, a common problem in today’s artificial hearts.

The study, published in Scientific Reports, was done in collaboration with the company Scandinavian Real Heart AB, which is developing an .

“The heart is a muscle that never rests. It can never rest. The heart can beat for a hundred years without being serviced or stopping even once. But constructing a pump that can function in the same way—that’s a challenge,” says Tino Ebbers, professor of physiology at Linköping University.

Home high-intensity aerobic training outperforms balance training for cerebellar ataxias

Columbia University Medical Center-led research reports that home high-intensity aerobic training improved ataxia symptoms, fatigue, and aerobic fitness more than dose-matched home balance training in individuals with cerebellar ataxias.

Cerebellar ataxias are a group of different disorders marked by progressive loss of coordination that leads to disability. About 150,000 people in the US live with these conditions, with mean annual health care costs above $18,000 per person. Ongoing trials are searching for treatments that slow disease progression and improve functional abilities. Clinical practice guidelines advise balance training for .

Previous work in ataxia has centered on balance-focused programs that can improve Scale for the Assessment and Rating of Ataxia (SARA) scores by 1.0 to 2.8 points when exercises are sufficiently challenging, a range that meets or exceeds the minimal clinically significant difference of 1.0 point.

Groove is in the brain: Music supercharges brain stimulation

Music affects us so deeply that it can essentially take control of our brain waves and get our bodies moving. Now, neuroscientists at Stanford’s Wu Tsai Neurosciences Institute are taking advantage of music’s power to synchronize brain waves to boost the effectiveness of a technique called transcranial magnetic stimulation (TMS), a promising tool for both basic brain research and treating neuropsychiatric disorders.

Specifically, institute affiliate Jessica Ross and colleagues used TMS pulses to induce movements in people’s hands—a common testing ground for new ideas in the field. By carefully timing those pulses to music, the team found they could double the impact of TMS.

“Because there’s this really strong connection to movement, music can engage motor pathways in the brain. If you’re listening to a certain kind of rhythm, there are going to be very specific times at which your brain is most ready for the TMS effect,” said Ross, an instructor in the Department of Psychiatry and Behavioral Sciences at Stanford Medicine.

Smart device uses AI and bioelectronics to speed up wound healing process

As a wound heals, it goes through several stages: clotting to stop bleeding, immune system response, scabbing, and scarring. A wearable device called “a-Heal,” designed by engineers at the University of California, Santa Cruz, aims to optimize each stage of the process. The system uses a tiny camera and AI to detect the stage of healing and deliver a treatment in the form of medication or an electric field. The system responds to the unique healing process of the patient, offering personalized treatment.

The portable, wireless device could make wound therapy more accessible to patients in remote areas or with limited mobility. Initial preclinical results, published in the journal npj Biomedical Innovations, show the device successfully speeds up the healing process.

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