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Molecular quantum nanosensors reveal temperature and radical signals inside living cells

Researchers at the National Institutes for Quantum Science and Technology (QST), Japan, and The University of Tokyo, Japan, in collaboration with Kyushu University, Japan, have developed a new class of biocompatible molecular quantum nanosensors (MoQNs) that operate inside living cells.

The study demonstrates that these nanosensors enable absolute temperature measurements with subcellular spatial resolution and detect radical-related spin signals in both the cytoplasm and nucleus of living cancer cells. The study was published in the journal Science Advances.

Hidden 3D atomic structure of relaxor ferroelectrics revealed for first time

Materials called relaxor ferroelectrics have been used for decades in technologies like ultrasounds, microphones, and sonar systems. Their unique properties come from their atomic structure, but that structure has stubbornly eluded direct measurement.

Now a team of researchers from MIT and elsewhere has directly characterized the three-dimensional atomic structure of a relaxor ferroelectric for the first time. The findings, reported in Science, provide a framework for refining models used to design next-generation computing, energy, and sensing devices.

“Now that we have a better understanding of exactly what’s going on, we can better predict and engineer the properties we want materials to achieve,” says corresponding author James LeBeau, MIT’s Kyocera Professor of Materials Science and Engineering.

Astronomers explore the surface composition of a nearby super-Earth

Using MIRI (Mid-Infrared Instrument) on board the James Webb Space Telescope (JWST), a team of researchers led by former MPIA (Max Planck Institute for Astronomy, Heidelberg, Germany) Ph.D. student Sebastian Zieba (Center for Astrophysics | Harvard & Smithsonian, Cambridge, U.S.) and Laura Kreidberg, MPIA Director and study PI (principal investigator), analyzed the surface composition of the rocky exoplanet LHS 3844 b.

Starting DNA Synthesis: Initiation Processes during the Replication of Chromosomal DNA in Humans

The initiation reactions of DNA synthesis are central processes during human chromosomal DNA replication. They are separated into two main processes: the initiation events at replication origins, the start of the leading strand synthesis for each replicon, and the numerous initiation events taking place during lagging strand DNA synthesis. In addition, a third mechanism is the re-initiation of DNA synthesis after replication fork stalling, which takes place when DNA lesions hinder the progression of DNA synthesis. The initiation of leading strand synthesis at replication origins is regulated at multiple levels, from the origin recognition to the assembly and activation of replicative helicase, the Cdc45–MCM2-7–GINS (CMG) complex.

A bright moon may dim the Eta Aquarid meteor shower made up of Halley’s comet debris

The Eta Aquarid meteor shower soon will light the sky with debris from Halley’s comet. But a bright moon will spoil the fun this year, making the display harder to glimpse.

The shower will peak Tuesday night into Wednesday morning. Viewers from the Southern Hemisphere typically see 50 meteors per hour during the peak, but the interfering moon could cut that number by half. In the north, skywatchers will likely see fewer than 10 per hour.

“For us in the Northern Hemisphere, it’s not going to be as impressive,” said Teri Gee, manager of the Barlow Planetarium in Wisconsin. “The farther south you are, the better you’ll see it.”

Brain motion is driven by mechanical coupling with the abdomen

UNIVERSITY PARK, Pa. — The brain is more mechanically connected to the body than previously appreciated, scientists reported today (April 27) in Nature Neuroscience. Through a study using mice and simulations, the team found a potential biological mechanism underlying why exercise is thought to benefit brain health: abdominal contractions compress blood vessels connected to the spinal cord and the brain, enabling the organ to gently move within the skull. This swaying facilitates the surrounding cerebrospinal fluid to flow over the brain, potentially washing away neural waste that could cause problems for brain function.

According to Patrick Drew, professor of engineering science and mechanics, of neurosurgery, of biology and of biomedical engineering at Penn State, the work builds on previous studies detailing how sleep and neuron loss can influence how and when cerebrospinal fluid flushes through the brain.

“Our research explains how just moving around might serve as an important physiological mechanism promoting brain health,” said Drew, corresponding author on the paper. “In this study, we found that when the abdominal muscles contract, they push blood from the abdomen into the spinal cord, just like in a hydraulic system, applying pressure to the brain and making it move. Simulations show that this gentle brain movement will drive fluid flow in and around the brain. It is thought the movement of fluid in the brain is important for removing waste and preventing neurodegenerative disorders. Our research shows that a little bit of motion is good, and it could be another reason why exercise is good for our brain health.”

Drew, who also holds the title of associate director of the Huck Institutes of the Life Sciences, explained how in a hydraulic system, a pump creates pressure that drives fluid flow. In this case, the pump is the abdominal contraction — which can be as light as the tensing prior to sitting up or taking a step. The contraction puts pressure on the vertebral venous plexus, a network of veins that connect the abdominal cavity to the spinal cavity, causing the brain to move.

Abstract: Nature Neuroscience Brain motion is driven by mechanical coupling with the abdomen.

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