Lifeboat Foundation

Macroautophagy (hereafter autophagy) is a cellular recycling process that degrades cytoplasmic components, such as protein aggregates and mitochondria, and is associated with longevity and health in multiple organisms. While mounting evidence supports that autophagy declines with age, the underlying molecular mechanisms remain unclear. Since autophagy is a complex, multistep process, orchestrated by more than 40 autophagy-related proteins with tissue-specific expression patterns and context-dependent regulation, it is challenging to determine how autophagy fails with age. In this review, we describe the individual steps of the autophagy process and summarize the age-dependent molecular changes reported to occur in specific steps of the pathway that could impact autophagy.

Researchers in Abu Dhabi say they have found a faster way to search desert areas for important archaeological sites buried beneath the sand.

A new device at the University of Central Florida captures carbon dioxide and turns it into useful products.

It’s 7 billion years ago, and the universe’s heyday of star formation is beginning to slow. What might our Milky Way galaxy have looked like at that time? Astronomers using NASA’s James Webb Space Telescope have found clues in the form of a cosmic question mark, the result of a rare alignment across light-years of space.

“We know of only three or four occurrences of similar gravitational lens configurations in the observable universe, which makes this find exciting, as it demonstrates the power of Webb and suggests maybe now we will find more of these,” said astronomer Guillaume Desprez of Saint Mary’s University in Halifax, Nova Scotia, a member of the team presenting the Webb results.

While this region has been observed previously with NASA’s Hubble Space Telescope, the dusty red galaxy that forms the intriguing question-mark shape only came into view with Webb. This is a result of the wavelengths of light that Hubble detects getting trapped in cosmic dust, while longer wavelengths of infrared light are able to pass through and be detected by Webb’s instruments.

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The lack of water was particularly impacting Indigenous communities who depend on the river for food and transport, it added.

AFP has observed boats stranded around Leticia, capital of the southern Amazonas state, in recent days, with large swathes of land exposed by low water levels.

Continue reading “Drought reduces Amazon River in Colombia by as much as 90%: report” »

Her initial workup revealed enlarged mediastinal nodes, bilateral ground glass interstitial opacities with areas of septal thickening, an incidental 4-cm left lower lobe nodular mass, multiple hypermetabolic lesions in the liver (the largest was 2.8 cm with a standard uptake value of 43), and osseous metastatic disease.

Ultrasound-guided biopsy showed poorly differentiated metastatic lung adenocarcinoma (stage 4) with 5% tumor cells expressing PD-L1 and negative for EGFR/ALK gene alterations.

Artificial intelligence start-ups are making revenues more quickly than previous waves of software companies, according to new data that suggests that the transformative technology is also generating strong businesses at an unprecedented rate.

According to an analysis of payments information from fintech group Stripe, top AI groups are reaching millions of dollars in sales within a year — far faster in a start-up’s life cycle than comparable non-AI tech groups.

The findings come as investors raise questions about the economic benefits of generative AI and likely returns on Big Tech’s projected trillion-dollar investment in computing infrastructure to support the technology over the coming year.

EPFL researchers developed Handcrawler, a robot hand that grasps and crawls.

EPFL’s ‘Handcrawler’ is a robotic hand that detaches and crawls like a spider to retrieve objects, then seamlessly reattaches.

Continue reading “Handcrawler: Evil Dead-like robotic hand detaches, crawls, and grasps” »