Joseph P. Mizgerd & team provide a Commentary on Christina Malainou et al.: https://doi.org/10.1172/JCI185390
2Department of Virology, Immunology, and Microbiology.
3Department of Medicine, and.
4Department of Biochemistry and Cell Biology, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts, USA.
This diagnostic study validates the biological comparability of brain amyloid thresholds used in AlzheimerDisease diagnostics across racial and ethnic subgroups of older adults, with no significant differences by sex or APOE4 status.
Further research should determine whether uniform thresholds yield comparable prognostic utility in clinical practice.
Here, Jennifer M. Lund & team report immune cells mobilize and co-localize in the vaginal epithelium, expressing cytotoxic, inflammatory and immunoregulatory genes that may promote tissue homeostasis to limit damage:
The image shows visualization of cells on a representative tissue section for spatial transcriptomics.
Address correspondence to: Jennifer M. Lund, 1,100 Fairview Ave. N., E5-110, Seattle, Washington 98,109, USA. Phone: 206.667.2217; Email: [email protected]. Or to: Jairam R. Lingappa, 908 Jefferson St., Box 359,927, Seattle, Washington 98,104, USA. Phone: 206.520.3822; Email: [email protected].
Adding coronary CT angiography (CCTA) data to traditional risk scores and coronary artery calcium scoring improved risk prediction for first coronary events over nearly 8 years of follow-up.
While the clinical impact was modest in a low-risk population, CCTA enhanced risk discrimination and reclassification, particularly among those considered low risk by conventional models.
This cohort study assesses whether coronary computed tomography angiography improves risk prediction beyond traditional risk factors and coronary artery calcium score in identifying individuals at risk of first coronary events.
Secondary bacterial infections are a common complication in influenza A infection, but targets for prevention are lacking.
Here, Susanne Herold & team suggest that targeting neutrophil-driven alveolar macrophage death in severe influenza pneumonia strengthens host defense and prevents the transition to secondary bacterial infection:
The figure shows leukocyte infiltration in mouse lung tissue caused by pneumococcal infection a week after influenza A infection.
1Department of Medicine V, Internal Medicine, Infectious Diseases and Infection Control, Universities of Giessen and Marburg Lung Center (UGMLC), member of the German Center for Lung Research (DZL), member of the German Center for Infection Research (DZIF), Justus Liebig University Giessen, Giessen, Germany.
2Institute of Lung Health (ILH), Justus Liebig University Giessen, Giessen, Germany.
3Excellence Cluster Cardio-Pulmonary Institute (CPI), Hessen, Germany.
Dr. Martin Picard tells the ‘story behind the paper’ for “A human brain map of mitochondrial respiratory capacity and diversity”. An amazing effort with a valuable dataset as the result!
(https://martinpicard.substack.com/p/voxelizing-the-human-brain)
This is the story of how we produced the first brain map of mitochondria—or the human brain bioenergetic landscape. The paper was published in the journal Nature.
