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Rim Lesions and Development of MS in Radiologically Isolated Syndrome

In #RadiologicallyIsolatedSyndrome, greater paramagnetic rim lesion burden on MRI was associated with increased risk and earlier development of clinical MultipleSclerosis.

Question Are paramagnetic rim lesions (PRLs) and central vein sign–positive white matter lesions (CVS+L) associated with developing clinical symptoms of multiple sclerosis (MS) in people with radiologically isolated syndrome (RIS)?

Findings In this cohort of 36 people with RIS, a higher PRL count was associated with a shorter time to developing clinical symptoms of MS and was an independent predictor of symptom onset; these findings were validated in an independent cohort of 43 people with RIS.

Meaning Results show that PRLs may have prognostic utility for risk stratification and help guide treatment decisions in people with RIS, the earliest detectable stage of MS.

Complement C5 Inhibitor Ameliorates a Case of Dysferlinopathy

Complement inhibition showed promising clinical improvement in this single case of dysferlinopathy.

Dysferlinopathy is a rare autosomal recessively inherited myopathy, presenting as several phenotypes, including a proximal weakness dominant limb-girdle muscular dystrophy R2 phenotype and a distal weakness dominant Miyoshi distal myopathy phenotype.1,2 Muscle weakness usually emerges in young adulthood, followed by a progressive motor decline over the first decade, which tends to be more rapid in individuals with earlier onset.3 Dysferlinopathy is caused by pathogenic variants of the DYSF gene that impair function of dysferlin, a protein that cooperates with others to repair membranes and restore skeletal muscle integrity after injury.4

To date, no effective treatment for dysferlinopathy has been clinically validated. Promising approaches, including exon skipping and gene editing targeting the DYSF gene, as well as myoblast transplantation, are still under investigation in preclinical models.5 Although dysferlinopathy often presents with inflammatory features on muscle pathology and is prone to misdiagnosis as myositis, it is characterized by the absence of focal MHC-I expression and complement C5b-9 deposition on nonnecrotic sarcolemma, which help distinguish it from other muscular dystrophies and inflammatory myopathies.6,7 Specially, complement C3 gene knockout in dysferlin-deficient mice has been demonstrated being able to reverse muscle pathology and improve motor function in the previous animal research.

Regulating the Impact of Hypertension on Stroke: Therapeutic Potential of a Peptide Mimetic of Tyrosine Phosphatase STEP

Even with delayed intervention, this neuroprotective agent delivers lasting protection to the hypertensive brain from ischemic injury.

BackgroundIn spite of the advances in understanding the pathophysiology of stroke, successful treatment remains a major challenge. The lack of consideration of preclinical studies with associated comorbidities is a primary factor for the translational failure, as ~94% of patients with stroke have ≥1 preexisting comorbidities. Because hypertension is the most common comorbid condition in patients with stroke and predisposition to hypertension is known to worsen stroke outcome, we evaluated the efficacy of a novel neuroprotective peptide derived from the brain‐enriched and neuron‐specific tyrosine phosphatase striatal enriched phosphatase (STEP) in attenuating ischemic brain damage under hypertensive conditions.

Morphological characteristics of healthy and aneurysmal internal carotid artery bifurcations

Internal carotid artery (ICA) bifurcation (ICAB) aneurysms carry high rupture risk, treatment challenges, and recurrence due to complex morphology and origination patterns. Given their relatively low incidence, research on ICAB morphology is limited. This study analyzed ICAB morphology in aneurysmal, contralateral, and healthy bifurcations, highlighting bilateral differences, anterior cerebral artery (ACA) dominance, and deviations from the vascular optimality principle (VOP).

A total of 194 angiographic volumes (40 aneurysmal, 28 contralateral, 126 healthy) were evaluated. ICAB morphology included parent/daughter vessel diameters and angle between the ICA and middle cerebral artery (MCA; ФMCA), angle between the ICA and ACA (ФACA), total ICAB angle (ФICAB; ФMCA + ФACA). Aneurysm characteristics (size, neck, origination) and VOP parameters (radius ratio [RR] and junction exponent [n]) were evaluated. Bilateral analysis accounted for ACA dominance.

Compared with controls, aneurysmal ICABs exhibited wider ΦMCA (57.22° ± 12.22° vs 43.74° ± 9.41°, p < 0.001; area under the curve [AUC] = 0.83) and ΦICAB (160.27° ± 16.16° vs 143.66° ± 10.74°, p < 0.001; AUC = 0.79), but not ΦACA, in univariate, multivariate (AUC = 0.85), and bilateral analyses. Angle thresholds of 51.7° for ΦMCA and 152.4° for ΦICAB were identified. Aneurysms originated predominantly off the apex (65%) and ACA (30%). Most occurred on ICABs with dominant (31%) and codominant (58%) A1 segments. Aneurysm neck, but not size, correlated with ΦMCA and ΦICAB, but not ΦACA. In controls, ΦMCA was larger and ΦACA smaller on the dominant A1 side, with no ΦICAB difference. There was no statistically significant difference in RR and n values regardless of aneurysm presence and dominance status.

Meet the soft humanoid robot that can grow, shrink, fly and walk on water

Humanoid robots look impressive and have enormous potential to change our daily lives, but they still have a reputation for being clunky. They’re also heavy and stiff, and if they fall, they can easily break and injure people around them.

But that could be about to change. Researchers at the Southern University of Science and Technology (SUST) in Shenzhen have unveiled a soft humanoid robot that can change its size, squeeze through spaces, and even walk on water. The key to this outstanding flexibility is a system the team developed called GrowHR. The research, published in Science Advances, describes how the robot was inspired by the way human bones develop.

Dr. Natalie Yivgi-Ohana, Ph.D. — CEO, Minovia — Harnessing The Therapeutic Power Of Mitochondria

Dr. Natalie Yivgi-Ohana, Ph.D. — CEO, Minovia Therapeutics — Harnessing The Therapeutic Power Of Mitochondria

Is Co-Founder and CEO of Minovia Therapeutics (https://minoviatx.com/), a biotech company dedicated to rapidly advance life-changing therapies that address the unmet need of serious and complex mitochondrial diseases, and are the first clinical-stage company to develop a mitochondrial transplantation approach to treat a broad range of indications generated by a mitochondrial dysfunction which lead to rare-genetic or age-related diseases.

Dr. Yivgi-Ohana has twenty years of experience in mitochondrial research and received her Ph.D. in Biochemistry at The Hebrew University, after which she completed her postdoctoral fellowship at the Weizmann Institute of Science.

Dr. Yivgi-Ohana also has her B.Sc., Medical Sciences Ben-Gurion University of the Negev and her Master’s Degree, Human Reproduction Bar-Ilan University.

Dr. Yivgi-Ohana founded Minovia with a passion to help children and adults with mitochondrial diseases worldwide.

Continue reading “Dr. Natalie Yivgi-Ohana, Ph.D. — CEO, Minovia — Harnessing The Therapeutic Power Of Mitochondria” | >

Epic Games & Google Reveal $800 Million Deal Amid Lawsuit

During a recent hearing in San Francisco, Epic’s CEO Tim Sweeney revealed that the agreement is related to Fortnite’s metaverse: “Epic’s technology is used by many companies in the space Google is operating in to train their products, so the ability for Google to use the Unreal Engine more fullsome… sorry, I’m blowing this confidentiality.”

In this partnership, Epic will spend $800 million to buy some unannounced services from Google. However, this is not a joint product made by the companies. “This is Google and Epic each separately building product lines,” Sweeney said.

Sweeney doesn’t see anything wrong with paying Google “to encourage much more robust competition than they’ve allowed in the past,” he said. “We view this as a significant transfer of value from Epic to Google.”

Enzyme as Maxwell’s Demon: Steady-State Deviation from Chemical Equilibrium by Enhanced Enzyme Diffusion

NoteL This is elegant theoretical physics showing an intriguing possibility, not a confirmed biological mechanism. It’s a “what if” scenario that could change how we view enzymes, but only if the controversial premise (EED) turns out to be real.

Enhanced enzyme diffusion (EED), in which the diffusion coefficient of an enzyme transiently increases during catalysis, has been extensively reported experimentally, although its existence remains under debate. In this Letter, we investigate what macroscopic consequences would arise if EED exists. Through numerical simulations and theoretical analysis, we demonstrate that such enzymes can act as Maxwell’s demons: They use their enhanced diffusion as a memory of the previous catalytic reaction, to gain information and drive steady-state chemical concentrations away from chemical equilibrium. Our theoretical analysis identifies the conditions under which this process could operate and discusses its possible biological relevance.

Heisenberg-limited Quantum Sensing Achieves Noise Resilience Via Indefinite-Causal-Order Error Correction

The research extends beyond theoretical analysis by outlining a feasible experimental implementation using integrated photonics. This includes a detailed description of the required optical components and control sequences for realising the ICO gate and performing the quantum sensing measurements. By leveraging the advantages of integrated photonics, the proposed scheme offers a pathway towards compact and scalable quantum sensors with enhanced performance characteristics. The findings pave the way for practical applications in fields such as precision metrology, biomedical imaging, and materials science.

Indefinite Causal Order for Real-Time Error Correction

Realistic noisy devices present significant challenges to quantum technologies. Quantum error correction (QEC) offers a potential solution, but its implementation in quantum sensing is limited by the need for prior noise characterisation, restrictive signal, noise compatibility conditions, and measurement-based syndrome extraction requiring global control. Researchers have now introduced an ICO-based QEC protocol, representing the first application of indefinite causal order (ICO) to QEC. By coherently integrating auxiliary controls and noisy evolution within an indefinite causal order, the resulting noncommutative interference allows an auxiliary system to herald and correct errors in real time.

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