Westhoff & colleagues found that PTEN inhibition reduces cardiac fibrosis caused by the high blood pressure hormone AngII. Learn how to fight fibrosis from hypertension at.
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Engineers have created a 1-square-millimeter chip that can project a photograph onto an area smaller than the size of two human egg cells. This precise laser control could have applications in augmented reality, biomedical imaging, and quantum computing.
MEMS array to steer lasers for quantum computer finds other uses.
A detector buried deep in Antarctic ice has captured the first experimental evidence of a predicted but never-before-seen phenomenon: radio pulses generated when high-energy cosmic rays slam into the ice sheet and trigger particle cascades inside it. Through results published in Physical Review Letters, astronomers of the Askaryan Radio Array (ARA) Collaboration have validated a key technique, which they hope will eventually allow them to detect some of the rarest and most energetic particles in the universe.
In 1962, Soviet physicist Gurgen Askaryan predicted that high-energy particles passing through a dense material should produce a distinctive burst of radio waves. When such a particle strikes an atom, it triggers a cascade of secondary particles that sweeps up electrons from the surrounding material, creating a negatively charged shower front that radiates at radio frequencies.
This “Askaryan radiation” was later confirmed in lab experiments and detected in air, but observing it in ice proved far more challenging. This is partly due to the difficulty of distinguishing genuine signals from the many sources of radio noise in polar environments, and partly because the simulations needed to model the effect in ice have only recently become sophisticated enough to make such rigorous analysis possible.
Li et al. show that putting gold nanoparticles inside of LNPs causes marked improvements in endosomal escape efficiency, describe a likely mechanism, and test their complexes with two therapeutic contexts in mice. A simple innovation which could greatly enhance LNP delivery!
Lipid Nanoparticles (LNPs) effectively deliver mRNA to cells but suffer have low levels of endosomal release. Here the authors report on core-shell LNPs with ionizable lipid–coated gold nanoparticle cores with enhanced pH-responsive membrane disruption, endosomal escape, and cytosolic mRNA delivery improving therapeutic efficiency.
That would mean generations upon generations of human lifetimes, all lived out on board a rocket ship travelling across space, in the hope of a comfortable utopia waiting for us when we arrive.
Now, a team of researchers say they’ve demonstrated a form of light-driven propulsion that could one day get us to Alpha Centauri in 20 years.
A team of researchers at the J. Mike Walker ’66 Department of Mechanical Engineering at Texas A&M University say they’ve demonstrated lasers can be used to lift and steer objects without physical contact.
While doing research during the works of the SRI 4th World Congress, I am trying to deepen my knowledge of the immense work done by Gerard K. O’Neill and his Space Studies Institute (SSI) during the second half of the past century.
Gerry took the work where Tsiolkovsky, Oberth, von Braun, and others had left it, on the great theme of rotating habitats in free space. And more, the SSI, founded by him, has developed an incredible amount of very high-profile studies about space manufacturing [1], covering many aspects of living in free-space habitats. Not only scientific and technical issues. According to the O’Neill teachings—as his main references, like Krafft Ehricke and others, had done—human requirements, attention to life and health protection, human rights, and social needs informed all of the developed studies and conceptual design.
Great outreachers like Isaac Asimov, Arthur Clarke, and Stanley Kubrick were ready to follow O’Neill and promote his concepts in their artworks and in their interviews to TV and media magazines.
Modern life depends on fast and reliable wireless connections. Video calls, streaming services, virtual reality, and smart devices all place growing demands on networks that already serve billions of users. Most wireless data today travels through radio-based technologies such as Wi-Fi and cellular systems.
While these approaches have been highly successful, they face mounting challenges, including crowded radio spectrum, interference in dense indoor spaces, and rising energy consumption as more devices come online.
A promising complementary approach is optical wireless communication, which uses light instead of radio waves to transmit data. Light offers far more bandwidth than radio frequencies, does not interfere with existing wireless systems, and can be directed precisely at specific locations.
“Asking the question of, where did the entire universe come from, is no longer a question for poets and theologians and philosophers. This is a question for scientists, and we have some amazing scientific answers to this question that have defied even the wildest of our expectations.” Subscribe to Big Think on YouTube ► / @bigthink Up next, The mind-blowing circle of life, explained by a biologist ►
• The mind-blowing circle of life, explained… Ethan Siegel, theoretical astrophysicist and science communicator, author of the James Webb Space Telescope book, “Infinite Cosmos,” and writer of the science blog, “Starts With A Bang” joins us to explore the cosmic origins of our universe. Read Ethan’s companion article: https://bigthink.com/starts-with-a-ba… — Where did the entire universe come from? 0:57 — A question for scientists 1:43 — The quest for the beginning of the universe 2:21 — Hubble’s telescope 4:09 — Extragalactic objects 5:11 — Blueshifted vs redshifted 6:53 — General theory of relativity 7:50 — The cosmic egg 8:26 — The origin of The Big Bang 9:55 — A cosmological constant 14:24 — Scale invariant spectrum 15:13 — Testing for Cosmic Inflation 19:34 — Our cosmic origins 21:03 — Ethan Siegel, kilt influencer Read the video transcript ► https://bigthink.com/series/the-big-t…
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About Ethan Siegel: Ethan Siegel is a Ph.D. astrophysicist and author of “Starts with a Bang!” He is a science communicator, who professes physics and astronomy at various colleges. He has won numerous awards for science writing since 2008 for his blog, including the award for best science blog by the Institute of Physics. His three books “Treknology: The Science of Star Trek from Tricorders to Warp Drive,” “Beyond the Galaxy: How humanity looked beyond our Milky Way and discovered the entire Universe,” and “Infinite Cosmos: Visions From the James Webb Space Telescope” are available for purchase at Amazon. Follow him on X @startswithabang.
What if civilizations outgrow consciousness itself? Explore post-human minds, machine societies, and a future where awareness may no longer be required.
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/ discord Credits: Post-Consciousness Civilizations: Evolving Beyond Human Awareness Written, Produced & Narrated by: Isaac Arthur Edited by: Lukas Konecny Select imagery/video supplied by Getty Images Music Courtesy of Epidemic Sound http://epidemicsound.com/creator Sergey Cheremisinov, “Labyrinth” Chris Zabriskie, “Unfoldment, Revealment”, “A New Day in a New Sector”, “Oxygen Garden” Stellardrone, “Red Giant”, “Billions and Billions“
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Credits:
Post-Consciousness Civilizations: Evolving Beyond Human Awareness.
Written, Produced & Narrated by: Isaac Arthur.
Edited by: Lukas Konecny.
Select imagery/video supplied by Getty Images.
Music Courtesy of Epidemic Sound http://epidemicsound.com/creator.
Sergey Cheremisinov, \