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Legendary former Tekken boss says people don’t ‘properly evaluate’ Hidetaka Miyazaki’s ‘remarkable’ FromSoft career
“From that perspective, I can say that Dark Souls didn’t suddenly become a massive success overnight,” Harada said. “It was the result of everything Miyazaki and his team had built up through their previous titles.”
According to Harada, the acclaim that FromSoft enjoys feels like “almost complete reversals in attitude” compared to “the days when [Miyazaki] and his team were struggling the most.” It was a contributing factor to his own exhaustion with people who he says can only judge a game’s merits “by saying things like, ‘That title cost X billion yen to make and sold Y million copies.’”
The Sleepy Scientist
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Structural insight into the mechanism of bacterial pili retraction
Every year bacteria kill more than a million people worldwide through infections that no longer respond to antibiotics. In many cases, why those bacteria are so hard to stop comes down to their uniquely powerful structure.
On the surfaces of many disease-causing bacteria, fibers thousands of times thinner than a human hair bristle, acting like biological grappling hooks. These fibers help bacteria latch onto body tissue, build biofilms, which are sticky bacterial communities that antibiotics struggle to penetrate, and reel in fragments of DNA from their environment, including genes that help them resist drugs.
Now, scientists have solved a key mystery about how those hooks work. A new study, published in the Proceedings of the National Academy of Sciences, reveals the molecular mechanism behind one of the most powerful mechanical actions in all of biology, the reeling in of tiny surface fibers called type IV pili.
New brush test detects oral cancer in one hour
A paper published in the journal Biomarker Research by a cross-university team led by Queen Mary University of London researchers validates the use of a noninvasive brush biopsy test that can detect oral cancer within one hour.
This test could revolutionize oral cancer detection and prevent more than 90% of unnecessary harmful scalpel biopsy procedures. These can be very painful, lead to infection and, in some areas of the mouth, such as the gum, are hard to carry out and may damage the underlying tooth and bone structure.
Oral cancer is a growing global killer. According to Global Burden of Disease data, lip and oral cancer are among the world’s most rapidly increasing causes of early death. More than 10,000 people in the UK were diagnosed with oral cancer last year, according to the charity Mouth Cancer, and 3,637 people died. Worldwide, it affects 650,000 people a year. Risk factors include tobacco use and smoking, alcohol, infection with the HPV virus, and sun damage. Unfortunately, more than half (53%) of all mouth cancers are diagnosed in stage IV, when the cancer is at its most advanced.
What’s at the center of Claude’s mind?
Out of everything happening in your brain right now, only a tiny fraction is consciously accessible — thoughts you can describe, hold in mind, and reason with.
Anthropic found a strikingly similar divide inside their AI model, Claude.
Their experiments were inspired by a leading theory in neuroscience: the global workspace theory. It holds that a thought becomes consciously accessible when it enters a shared “workspace” that’s broadcast across the brain.
They found a set of representations in Claude’s neural activity that play a similar role.
How a Revolutionary Cancer Treatment Could Reset the Immune Systems of Patients With Autoimmune Diseases
But there are other possible CAR T risks for autoimmune patients. In February, FDA officials published a paper endorsing CAR T’s potential in autoimmunity but warning of “unpredictable long-term toxicity.” CAR T treatment for cancer, the authors noted, has been linked to diverse long-term issues such as Parkinson’s disease. There have also been cases in which the bioengineered cells themselves turned malignant, causing new, T cell-based cancers.
Causing a secondary cancer may be an acceptable risk when treating a life-threatening cancer, but probably not for autoimmunity, says Matt Lunning, medical director for gene and cellular therapy at Nebraska Medicine, in Omaha. How to balance the risk between the impacts of an autoimmune disease, which can range widely in severity, and the difficult-to-quantify risk of future side effects or cancers remains a major open question.
Researchers are already working on second-and third-generation versions of CAR T that they expect to be safer for both cancer and autoimmunity. For example, James Howard, a neuromuscular neurologist at the University of North Carolina at Chapel Hill, is testing a technology from a company called Cartesian Therapeutics that encodes the CAR using molecules of mRNA, the short-lived genetic messenger used in Covid-19 vaccines, instead of long-lasting DNA. The CAR T cells should wipe out B cells for only as long as the mRNA persists, then lose their B cell-targeting abilities. With no chance for genetically modified T cells to hang around long-term, there should be no cancer risk.
Antibiotics reverse damage caused to blood stem cells by chronic Salmonella
2 Helen Diller Comprehensive Cancer Center, UCSF, San Francisco, California, USA.
3Department of Computational Biology, St. Jude Children’s Research Hospital, Memphis, Tennessee, USA.
4Department of Neurological Surgery, Malnati Brain Tumor Institute of the Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
PET scans reveal stage-linked tau signal in Huntington’s disease brains
A study conducted by the Sant Pau Research Institute (IR Sant Pau) and Hospital de Sant Pau has identified for the first time in living individuals a brain pattern related to the tau protein that changes according to the stage of Huntington’s disease. This discovery opens the door both to the use of new biomarkers for monitoring the disease and to the development of treatments for a condition for which no therapeutic options are currently available.
Using positron emission tomography—a molecular neuroimaging technique known as PET—and the second-generation radiotracer [¹⁸F]PI-2620, the researchers demonstrated that this signal can already be detected in some mutation carriers who have not yet developed clinically manifest disease and that, as the disease progresses, the signal increases and spreads according to an organized anatomical distribution.
The study, published in the European Journal of Nuclear Medicine and Molecular Imaging, provides new insights into the biological processes that occur between the genetic alteration responsible for the disease and the onset of its motor, cognitive and neuropsychiatric manifestations.