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Potential Anti-Cancer Fungal Compound Finally Synthesized After 55 Years

The fungal compound verticillin A, discovered more than 50 years ago, has long been regarded for its potential cancer-fighting capabilities. S cientists have now managed to artificially synthesize the compound for the first time, meaning they can study it in more detail and potentially develop new cancer treatments.

Being able to produce verticillin A on demand in the lab is a major step forward. In nature, it’s found only in small amounts in a microscopic fungus and is very difficult to extract.

Before now, the complex chemical structure and inherent instability of verticillin A made it tricky to synthesize, but researchers from MIT and Harvard Medical School have overcome both problems.

Astronomers Witness ‘Missing Link’ in Planet Formation

“What’s so exciting is that we’re seeing a preview of what will become a very normal planetary system,” said Dr. John Livingston.

How are the most common types of planets made? This is what a recent study published in Nature hopes to address as a team of scientists investigated the intricate processes responsible for the most common types of exoplanets—super-Earths and sub-Neptunes—to form and evolve. This study has the potential to help scientists better understand not only planetary formation and evolution, but for solar systems, as our solar system doesn’t have super-Earths or sub-Neptunes.

For the study, the researchers conducted a multi-year examination of the V1298 Tau system, which is an approximately 20-million-year-old system located about 350 light-years from Earth and hosts four growing exoplanets orbiting in a tight formation, and each being between 5 to 10 Earth radii. Given the young age of the system, as our solar system is about 4.5 billion-years-old, the goal of the study was to predict the sizes of the four planets when they stop evolving.

In the end, the researchers ascertained that while the four young planets are between 5–10 Earth radii right now, they will end up being between 1–4.5 Earth radii when they are done forming. They note this is due to the rapid cooling they underwent after initial formation due to their small masses and large radii, resulting in their shrinking while losing their atmospheres, with one of the researchers calling this the “missing link” in understanding the formation of super-Earth and sub-Neptunes, which are the most common types of exoplanets.

AI-generated sensors open new paths for early cancer detection

Detecting cancer in the earliest stages could dramatically reduce cancer deaths because cancers are usually easier to treat when caught early. To help achieve that goal, MIT and Microsoft researchers are using artificial intelligence to design molecular sensors for early detection.

The researchers developed an AI model to design peptides (short proteins) that are targeted by enzymes called proteases, which are overactive in cancer cells. Nanoparticles coated with these peptides can act as sensors that give off a signal if cancer-linked proteases are present anywhere in the body.

Depending on which proteases are detected, doctors would be able to diagnose the particular type of cancer that is present. These signals could be detected using a simple urine test that could even be done at home.

Single-cell and spatial profiling highlights TB-induced myofibroblasts as drivers of lung pathology

In a new study from Ian M. Mbano, Nuo Liu, Paul T. Elkington, Alex K. Shalek, Alasdair Leslie (University of KwaZulu-Natal) and colleagues, single-cell and spatial transcriptomics of human TB lung tissues from individuals in South Africa revealed that MMP1⁺CXCL5⁺ fibroblasts & SPP1⁺ macrophages are linked to TB disease & TB lung granuloma.

Ian M. Mbano, Nuo Liu, Marc H. Wadsworth, Mark J. Chambers, Thabo Mpotje, Osaretin E. Asowata, Sarah K. Nyquist, Kievershen Nargan, Duran Ramsuran, Farina Karim, Travis K. Hughes, Joshua D. Bromley, Robert Krause, Threnesan Naidoo, Liku B. Tezera, Michaela T. Reichmann, Sharie Keanne Ganchua, Henrik N. Kløverpris, Kaylesh J. Dullabh, Rajhmun Madansein, Sergio Triana, Adrie J.C. Steyn, Bonnie Berger, Mohlopheni J. Marakalala, Sarah M. Fortune, JoAnne L. Flynn, Paul T. Elkington, Alex K. Shalek, Alasdair Leslie; Single-cell and spatial profiling highlights TB-induced myofibroblasts as drivers of lung pathology. J Exp Med 2 March 2026; 223 : e20251067. doi: https://doi.org/10.1084/jem.20251067

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How energy, immune and vascular changes linked to ME/CFS

The study compared whole blood samples from 61 people meeting clinical diagnostic criteria for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) with samples from healthy age-and sex-matched volunteers.

White blood cells from ME/CFS patients showed evidence of ‘energy stress’ in the form of higher levels of adenosine monophosphate (AMP) and adenosine diphosphate (ADP), indicating reduced generation of adenosine triphosphate (ATP), the key energy source within cells.

Profiling of immune cell populations revealed a trend toward less mature subsets of T-lymphocyte subsets, dendritic cells and natural killer cells in people with ME/CSF.

Comprehensive analysis of plasma proteins highlighted disruptions of vascular and immune homeostasis in patients with ME/CFS. Levels of proteins associated with activation of the endothelium – the innermost lining of blood vessels – and remodelling of vessel walls were higher, while levels of circulating immunoglobulin-related proteins were lower.

Although cellular energy dysfunction and altered immune profiles have been noted before in patients with ME/CFS, previous studies have often focused on a single analytical platform without looking at concurrence and interactions.

“ME/CFS is a complex disorder with undefined mechanisms, limited diagnostic tools and treatments,” said the senior author of the study. “Our findings provide further insights into the clinical and biological complexity of ME/CFS.”

Continue reading “How energy, immune and vascular changes linked to ME/CFS” | >

Harnessing Wearable Tech in Gastrointestinal Care

Wearable technologies have the potential to transform gastrointestinal care by enabling continuous monitoring of activity in patients with cirrhosis and aiding in the early detection of hepatic encephalopathy. While these innovations provide valuable clinical insights, further efforts are needed to address challenges related to implementation and data management.

Current research into wearable technology in liver disease supports these possibilities. Studies of wrist-worn activity monitors have shown that reduced activity is associated with increased waitlist mortality among liver transplant candidates, as well as increased hospital admissions and mortality in patients with cirrhosis. Other investigations with wearables have linked sleep disturbances to poorer post-liver transplant outcomes and explored skin patches and transdermal sensors for detecting blood alcohol levels and inflammatory markers predictive of outcomes in cirrhosis, Buckholz said.

A major barrier to widespread implementation in clinical practices is the so-called “wearable paradox,” whereby early adopters of wearable technology tend to be relatively healthy, whereas those at highest risk are less likely to already use such devices, Buckholz noted. Increasing access, understanding, and uptake in vulnerable populations will therefore be critical.

Additional challenges include determining how to distill massive volumes of wearable data into concise formats that can be incorporated into electronic medical records (EMRs) and easily communicated to patients.

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