Over the past two decades, a powerful but highly specialized branch of control engineering—known as negative imaginary (NI) systems theory—has quietly evolved into a key tool for stabilizing complex, vibration-prone systems, from flexible structures to advanced robotics.
Now, a new study reveals how fast and in what direction this field is growing. By analyzing more than 400 scientific publications from 2004 to 2024 across the world’s leading academic databases, the researchers uncovered a clear trend: NI systems are no longer just a theoretical concept. The work is published in the International Journal of Systems Science.
The field is expanding rapidly, with increasing global participation and a strong shift toward real-world applications such as multi-robot coordination, aerospace systems and nanotechnology.
Large language models (LLMs), the computational models that underpin conversational agents such as Gemini and ChatGPT, are now widely used by people worldwide to rapidly find information, summarize documents and generate texts for specific purposes. Some computer scientists are now combining two or more of these models to create multi-agent systems, which prompt multiple artificial intelligence (AI) agents to interact, cooperate and/or compete with the goal of completing specific tasks.
In some scenarios, however, AI agents could have different objectives and might have access to more or less information than the other agents they are interacting with. Understanding how AI agents typically behave in these situations could help shed more light on the potential benefits and risks of multi-agent systems.
Researchers at Mila, Université de Montréal and McGill University recently set out to explore how the hidden goals of individual AI agents could influence a multi-agent system’s performance, using a framework inspired by the multiplayer social deduction game Werewolf.
One of the most iconic visual representations in biological science is the double helix – the twisting, twin-stranded ladder that defines the shape of DNA molecules.
But not all DNA follows this same recognizable pattern. Alternative kinds of DNA structures do exist, and new technologies are helping to reveal them.
In a study last year, scientists identified where these “non-canonical” forms of DNA (aka non–B DNA) emerge in human and other primate genomes.
Like spies evading detection by mastering disguises, many cancer cells are adorned with a copious coat of sugar-derived molecules that throws the proverbial hounds of the immune system off the scent.
Scientists at Sanford Burnham Prebys Medical Discovery Institute and collaborators across North America published findings Aug. 7, 2026, in Science Advances showing that cancer cells’ cloaking costumes can result from changes in the nearby neighborhood of immune cells, connective tissue, blood vessels, proteins and carbohydrates called the tumor microenvironment. The researchers also found a way to thin this sugary shroud, enabling cancer cells to be recognized and eliminated by the immune system.
Lead and corresponding author Kevin Tharp, Ph.D., knew that cells squeezed by their surroundings change their mitochondrial function in surprising ways. He realized that a key place where cells would experience this kind of physical pressure was in the tumor microenvironment.
Parkinson’s disease affects more than 10 million people worldwide. The disease is characterized by the buildup of abnormal clumps of the protein alpha-synuclein inside brain cells, but scientists have long struggled to understand exactly how these toxic forms of the protein cause neurons to malfunction and eventually die.
Researchers from the Tofaris lab, part of the Nuffield Department of Clinical Neurosciences and based in the Kavli Institute for Nanoscience Discovery, combined advanced molecular analyses of human stem cell models of Parkinson’s disease with studies of postmortem brain tissue from people with Parkinson’s disease to investigate the earliest stages of the disease process.
The study is published in the journal Nature Communications.
Cancer adapts and overcomes many different obstacles in order to survive. Since tumors are masses of rapidly growing cells, it takes a lot of nutrients, signaling, and proteins to help maintain proliferation. Over the last two decades, researchers have discovered that nerves provide tumors with signals, neurotransmitters, growth factors, and molecules to aid in cancer genesis, growth, survival, and progression. This process of nerves growing around and within the tumor is known as ‘tumor innervation’ or ‘nerve hacking’. This provides a source of nutrients for the tumor and makes the tumor microenvironment (TME) more complex or difficult to treat. Solid tumors in particular benefit from nerve hacking and more nerves innervating the tumor correlate with worse outcomes in patients. Therefore, researchers are working on understanding this process and how to best treat patients with increased tumor innervation.
Novel research published by scientists at the University of Oklahoma demonstrated how breast cancer cells can attract nerves to fuel their growth. It has been a mystery how nerves get to the tumor, until recently. This new study in Cell Death & Differentiation concludes that triple negative breast cancer (TNBC) uses the body’s own immune system to interconnect with nerves. The study performed by Dr. Maureen A. Cox and others clearly show that a specialized immune cell, known as a macrophage, is directly responsible for nerve hacking and tumor progression.
Cox is an Assistant Professor in the Department of Microbiology & Immunology within the College of Medicine at the University of Oklahoma. Her work focuses on the nervous systems and how nerves and immune cells interact to respond to cancer. Specifically, Cox investigates how immune cells facilitate nerve growth and subsequently promote cancer through indirect mechanisms.
What if everything you think you know about reality is only the surface? His followers believe Dr. Jacobo Grinberg may have unlocked a hidden world beneath our everyday experience, one where consciousness reshapes reality itself.
On December 8, 1994, this brilliant neuroscientist vanished without a trace, disappearing into thin air while investigating mysteries most scientists dared not touch.
Dr. Jacobo Grinberg was no ordinary scientist. He was a bold explorer of the mind, a pioneer in consciousness, on a quest to unlock new chapters of reality. But was Dr. Grinberg’s disappearance the end of his story, or the beginning of something far stranger?