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Immune checkpoint inhibitor therapies for cancer can induce unintended immune related adverse events (irAEs)

Here, Deepak A. Rao & team use mass cytometry immune profiling to identify T cell features in pre-treatment blood samples from patients that are associated with irAEs after ICI therapy.

1Division of Rheumatology, Inflammation, Immunity, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA.

2Division of Rheumatology, Hospital for Special Surgery and Weill Cornell Medicine, New York, New York, USA.

3Memorial Sloan Kettering Center and Weill Cornell Medical College, New York, New York, USA.

Powering AI from space, at scale, with a passive tether design

Penn Engineers have developed a novel design for solar-powered data centers that will orbit Earth and could realistically scale to meet the growing demand for AI computing while reducing the environmental impact of data centers.

Reminiscent of a leafy plant, with multiple, hardware-containing stems connected to branching, leaf-like solar panels, the design leverages decades of research on “tethers,” rope-like cables that naturally orient themselves under the competing forces of gravity and centrifugal motion. This architecture could scale to the thousands of computing nodes needed to replicate the power of terrestrial data centers, at least for AI inference, the process of querying tools like ChatGPT after their training concludes.

Unlike prior designs, which typically require constant adjustments to keep solar panels pointed toward the sun, the new system is largely passive, its orientation maintained by natural forces acting on objects in orbit. By relying on these stabilizing effects, the design reduces weight, power consumption, and overall complexity, making large-scale deployment more feasible.

Real-time imaging reveals new mechanisms for pancreatic ductal establishment and remodeling

Abigail Laura Jackson, Silja Heilmann, Pia Nyeng (Roskilde Universitet – RUC) and colleagues use a new apical polarity reporter mouse & high-resolution live imaging to demonstrate that pancreatic tubulogenesis is driven by dynamic transformations of existing lumens, which establish and remodel the pancreatic duct.

Jackson and Heilmann et al. use a new apical polarity reporter mouse and high-resolution live imaging to demonstrate that pancreatic tubulogenesis is drive.

Highly stable Cu₄₅ superatom could transform carbon recycling

After years of trying, scientists have finally created a stable superatom of copper, a long-sought-after chemical breakthrough that could revolutionize how we deal with carbon emissions.

Copper is a cheap and common metal, and because of its ability to bind carbon atoms together (C-C coupling), scientists have wanted to use it to turn carbon dioxide into products like ethylene for plastics and fuels. However, it corrodes or falls apart almost immediately when exposed to air or harsh industrial conditions.

A superatom is a cluster of atoms that behaves like a single atom, but with greater stability. In this new study published in the Journal of the American Chemical Society, scientists from Tsinghua University in Beijing built a nanocluster made from 45 copper atoms (Cu45).

Capturing the moment of organelle handoff inside living cells

For the first time, researchers have directly visualized how newly formed cellular organelles leave the endoplasmic reticulum (ER) and transition onto microtubule tracks inside living cells. This new finding reveals that the ER plays an active and dynamic role in steering intracellular traffic rather than serving as a passive factory. The study is published in the journal ACS Nano.

For the study led by Director Cho Minhaeng at the Center for Molecular Spectroscopy and Dynamics within the Institute for Basic Science and Professor Hong Seok-Cheol at Korea University, the research team captured in real time the moment an autophagosome—an organelle responsible for cellular recycling—moves from the ER onto a neighboring microtubule. This long-sought observation provides direct experimental evidence for how intracellular transport is coordinated at nanoscopic contact sites within the crowded environment of living cells.

Autophagy is an essential cellular process in which damaged proteins and aged organelles are enclosed by double-membrane structures and delivered for degradation and recycling. The importance of autophagy was recognized by the 2016 Nobel Prize in Physiology or Medicine awarded to Yoshinori Ohsumi. Although scientists have long proposed that autophagosomes are transferred from the ER to microtubules at specialized contact sites, direct real-time experimental evidence of this cellular “handoff” had remained out of reach—until now.

Lieutenant Colonel Erin Maurer — Surviving The Unthinkable: NATO’s Frontline CBRN Defense

Surviving the unthinkable: nato’s frontline CBRN defense — lieutenant colonel erin maurer, CBRN defense lead, J3 force protection directorate, allied joint force command brunssum, NATO.

Lieutenant Colonel Erin Maurer is the CBRN Defense Lead, J3 Force Protection Directorate, at NATO Joint Force Command Brunssum, The Netherlands (https://jfcbs.nato.int/), a position she has held since July 2024.

LTC Maurer enlisted in the United States Army Reserves in 2004, and upon graduating from Penn State University in 2008, commissioned as a Second Lieutenant through the Reserve Officers Training Corps (ROTC), branched Chemical Corps. Her assignments have included:

Brigade chemical officer, company executive officer, and forward operating base operations officer, for 4th infantry brigade combat team, 3rd infantry division, fort stewart, georgia;

Headquarters Company Commander, Support Battalion, 1st Special Warfare Training Group (Airborne);

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