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Retatrutide Reduces Knee Osteoarthritis Pain and Weight, Improves Physical Function
The investigational triple incretin agonist drug retatrutide was associated with significant improvement in knee osteoarthritis (OA) pain and physical function along with weight loss in people with painful knee osteoarthritis and obesity, data from two phase 3 trials showed.
“We saw very exciting amounts of pain reduction and function improvement over time. I think this is a big advance… Osteoarthritis has lacked effective therapies for so long,” study investigator Philip Conaghan, MBBS, PhD, director of the NIHR Biomedical Research Centre in Leeds and professor of musculoskeletal medicine at the University of Leeds, United Kingdom, told Medscape Medical News.
The data came from Eli Lilly’s TRIUMPH-4 trial, of once-weekly retatrutide in different doses compared with placebo for 68 weeks, and TRIUMPH-1-OA, a substudy of a larger trial investigating the triple GLP-1, GIP, and glucagon receptor agonist for treating obesity. Conaghan presented results from TRIUMPH-4 on November 8, 2026, and will present the TRIUMPH-1-OA data on November 10, 2026, both at the American College of Rheumatology (ACR) 2026 Annual Meeting in Orlando, Florida.
Scientists Simulated What Earth Would Be Like if Life Never Existed
We’re here. We’re not entirely sure how we got here, but we’re here.
But… what if we weren’t here?
That’s the question scientists posed in a new study, simulating an alternative vision of Earth where life, uh, never found a way.
GLP-1 drugs getting new labels warning of rare vision-loss condition
All GLP-1 drugs, which include popular brands like Ozempic and Wegovy, will soon carry new labels warning people taking the medications about a possible side effect that could lead to permanent vision loss.
Why you should care:
The Food and Drug Administration explained the labels will alert patients to a potential eye condition known as non-arteritic anterior ischemic optic neuropathy. While doctors do not know what causes the rare condition, it can lead to decreased blood flow through the optic nerve.
JAMA+ Trials Research, Education and Commentary from JAMA Network
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Why This Painful Disorder Can Take a Decade-Plus to Diagnose
A connective tissue disorder with wide-ranging symptoms, hypermobile Ehlers-Danlos syndrome can lead to serious complications and harm from a medical system that doesn’t understand it.
Directional VR passwords improve recall with a sense of place
Researchers have demonstrated a new password authentication technique for use in virtual reality (VR) settings, which allows users to choose directions rather than numbers. The approach supports the same number of possible combinations as a six-digit numeric password, but is much easier for users to remember.
“Passwords are a widely used element of the authentication process, giving users privacy and security,” says Yuxuan Huang, first author of a paper on the work and a postdoctoral researcher at North Carolina State University. “However, people often forget passwords or choose ones that are easy to remember, but less secure.
Immersive VR environments offer another approach, using directions or interactions with the environment in lieu of numbers and letters when entering a password, says Huang. This approach allows users to make use of their environmental context to help remember the password. Our goal was to make use of this approach to develop an authentication process that is memorable, but that also provides users with an efficient login process.
Did Life Begin in an RNA World?
Some believe the earliest life emerged from self-copying molecules that could mutate and even evolve. But that may not have been enough.
Prehistoric Britons may have made giant stone axes to show off
Unusually large handaxes weighing up to 3 kilograms have puzzled archaeologists because they are so unwieldy, but their function may have been purely symbolic
Nothing can be fully transparent, physicists discover
Quantum researchers show how materials inevitably absorb light