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New kind of dark tourism emerging in online ‘Backrooms,’ study shows

Digital culture is reshaping people’s experiences of fear, curiosity and belonging, according to new findings from Lancaster University. Researchers have explored why online environments like the “Backrooms”—mysterious empty spaces resembling uncharted office blocks, basements and corridors—have become so compelling, and why people are choosing to get lost in spaces that don’t exist.

Unlike traditional “dark tourism,” which focuses on physical sites and historical events, the “Backrooms” represent a new kind of experience that exists entirely online. They emerge from, and circulate through, the darker corners of the internet that are less visible, less regulated, and often more experimental in tone.

The research, co-authored by Dr. Sophie James and Professor James Cronin from Lancaster University Management School (LUMS), explains how, in these online spaces, people are not traveling to real locations, but entering shared digital environments that feel immersive, unsettling, and just out of reach.

Multiplexed MRI provides a comprehensive view of the human brain

New multiplexed imaging technology using standard clinical MRI systems can simultaneously map more than 20 biomarkers in high resolution, providing a comprehensive view of the brain with a single scan.

Researchers demonstrated the multiplexed MRI technology, or MRx, by characterizing brain tumors and multiple sclerosis lesions — revealing different structural, physiological and molecular changes within the diseases. The team reported its findings in the journal Nature.

“MRx can be a powerful tool for noninvasive tissue characterization, helping to advance personalized, precision and predictive medicine,” the author said. “By providing rich, multidimensional biomarkers to capture disease progression and treatment response, this capability could open new opportunities for more precise diagnosis, individualized treatment planning and improved patient outcomes.”

Recurrent Limitations of CAR-T Therapy in Gliomas: Evidence from Preclinical and Phase I Clinical Studies

In recent years, the development of new immunotherapy strategies has been a significant breakthrough in cancer treatment. Among these, engineered T cell therapy with chimeric antigen receptors (CAR-T) has produced notable clinical results, especially in hematological malignancies. This success has sparked growing interest in extending the application of CAR-Ts to solid tumors, including gliomas. Gliomas—in particular, glioblastoma multiforme (GBM)—are among the most aggressive primary brain tumors, associated with a poor prognosis and a median survival of approximately one year after diagnosis. However, the translation of CAR-T therapy to gliomas presents significant challenges, related to factors such as tumor heterogeneity, presence of the blood–brain barrier (BBB), and a strongly immunosuppressive tumor environment.

Neurotransmitter Systems in Alzheimer’s Disease

Alzheimer’s disease (AD), the leading cause of global dementia, is a multifactorial process that goes beyond the accumulation of β-amyloid (Aβ) plaques and tau protein tangles, including glia cell-mediated neuroinflammation, vascular dysfunction, metabolic alterations, and synaptic loss. Its complex etiology also involves oxidative stress and mitochondrial dysfunction. Multiple neurotransmitter systems involved in the pathogenesis and the various cognitive and non-cognitive symptoms of AD are thus altered. The cholinergic system, historically the first to be associated with AD, suffers early degeneration and loss of neurons/receptors, correlating with cognitive impairment. The glutamatergic system, the main excitatory system, exhibits excitotoxicity due to increased extracellular glutamate and alterations in NMDA/AMPA receptor distribution, exacerbating neuronal damage.

Unusual nonlinear thermoelectric effect appears in chiral tellurium, confirming theoretical predictions

An unusual thermoelectric effect has been observed in the semiconductor tellurium by RIKEN physicists for the first time. This demonstration points to the potential of similar materials to be used in applications such as energy harvesting and advanced heat management.

Thermoelectric materials can convert electricity into heat and vice versa. For most of them, doubling the voltage across them will double the heat they produce. But for some special thermoelectric materials, there is a nonlinear relationship between voltage and heat. Such nonlinear thermoelectric materials are useful for applications that require heat to flow in one direction and for generating electricity from thermal fluctuations.

Some theoretical calculations have predicted that even more exotic nonlinear thermoelectric effects will occur in materials where the atoms or molecules have a chiral arrangement. But they hadn’t been observed in the lab—until now.

Black holes may avoid singularities when charge and Hawking radiation combine, theoretical physicist argues

Black holes are regions in space where gravity is so strong that nothing, even light, can escape. Einstein’s theory of general relativity breaks down inside black holes, either by the presence of a so-called “curvature singularity” or “Cauchy horizon.”

A curvature singularity is a point where density and spacetime curvature become infinite, the laws of physics break down, and matter is crushed into an infinitely small space. A Cauchy horizon, on the other hand, is a boundary beyond which the future cannot be reliably predicted by known physics theories.

Francesco Di Filippo, a researcher at the Institute for Theoretical Physics in Frankfurt, recently carried out a theoretical study that challenges the assumption that black holes must inevitability possess either a singularity or a Cauchy horizon. His paper, published in Physical Review Letters, shows that the combination of electromagnetic repulsion from electric charge and quantum effects described by Stephen Hawking’s radiation theory could prevent the formation of singularities and Cauchy horizons in some black holes.

Quantum supremacy just ran into an unexpected rival: An ordinary laptop armed with new math

Using a conventional computer and cutting-edge mathematical tools and code, physicists at the Center for Computational Quantum Physics (CCQ) at the Simons Foundation’s Flatiron Institute and collaborators at Boston University have cracked a daunting quantum physics problem previously claimed to be solvable only by quantum computers.

The technique is so groundbreaking in its efficiency that the researchers were even able to use a personal laptop to solve the problem.

By enabling scientists to squeeze extra problem-solving power from classical computers, the breakthrough methodology is opening new avenues for research on quantum dynamics and may be useful as a protocol for solving problems about finding the optimal solution amid an abundance of feasible ones.

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