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Earth’s magnetic field creates a previously undetected pocket of protection from radiation on the moon

High-energy particles called galactic cosmic rays (GCRs) bombard unprotected objects in space, often causing damage. Earth, however, is protected by its magnetic field, which creates a protective shell around the planet that can deflect dangerous charged particles, like GCRs.

The moon is known to pass through the tail-like part of Earth’s magnetosphere, but a new study, published in Science Advances, suggests the moon might experience additional protection at another point in its orbit. Although this pocket of protection exists when the moon is outside of the magnetosphere, researchers believe the effects are still due to Earth’s magnetic field.

An anomalous dip in particle counts When the research team analyzed data taken from the Lunar Lander Neutron and Dosimetry (LND), onboard China’s Chang’E-4 lander, they were surprised to find that the LND experienced a 20% dip in GCR particles hitting detectors while the lander was on the moon’s far side. This occurred at a specific time during the lunar “morning” and only for about 2 days each lunar cycle. Since the LND took data over 31 cycles, the team could see that this was not just a one-off occurrence. This was unexpected because it was previously assumed that GCRs are evenly distributed in the space between Earth and the moon, outside Earth’s magnetosphere.

From stillage to storage: Turning bourbon byproducts into supercapacitors

The state of Kentucky produces 95% of the world’s bourbon, and all that bourbon leaves behind an enormous amount of waste grain, called stillage. Now, researchers at the University of Kentucky have developed a process to transform that stillage into electrodes. With the bourbon byproduct electrodes, they created supercapacitors that could store more nergy than similarly sized commercial devices. The researchers will present their results at the spring meeting of the American Chemical Society (ACS Spring 2026), held in Atlanta from March 22 to 26.

Turning bourbon stillage into carbon Josiel Barrios Cossio, a graduate student who will be presenting the work, first learned about the scale of American whiskey’s waste problem while working on a research traineeship to examine food, energy and water issues in Kentucky. “From the final volume of bourbon produced, you get 6 to 10 times that amount of stillage as waste,” says Barrios Cossio, “so it’s a big deal.”

This stillage is a sloppy mash that’s typically sold to farmers as livestock feed or a soil additive. But it is difficult to transport while wet, and it is expensive to dry.

Lawrence Krauss — Is the Universe Fine-Tuned for Consciousness?

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That the universe is fine-tuned for life, with multiple physical laws required to be within small ranges, is generally accepted. But can we then make the additional argument that the universe is somehow required to contain consciousness? Such a conclusion may not follow. But the key question is this: Is consciousness wholly contingent or somehow special?

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Lawrence Maxwell Krauss is a Canadian-American theoretical physicist and cosmologist who is a Foundation Professor of the School of Earth and Space Exploration, and director of the Origins Project at Arizona State University.

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Martin Rees — Is the Universe Fine-Tuned for Life and Mind?

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If the deep laws of the universe had been ever so slightly different human beings wouldn’t, and couldn’t, exist. All explanations of this exquisite fine-tuning, obvious and not-so-obvious, have problems or complexities. Natural or supernatural, that is the question.

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Martin John Rees, Baron Rees of Ludlow, is a British cosmologist and astrophysicist. He has been Astronomer Royal since 1995 and Master of Trinity College, Cambridge from 2004 to 2012. He was President of the Royal Society between 2005 and 2010.

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Radiation-induced autophagy regulates fibroblast mitochondrial metabolism and crosstalk with triple-negative breast cancer cells

Although radioresistant and circulating tumor cell survival has been attributed to altered metabolism, the metabolic impact of radiation therapy on stromal cells is unknown. Corn et al. demonstrate radiation-induced mitochondrial and metabolic changes in fibroblasts that are regulated by autophagy and drive growth in triple-negative breast cancer.

Lifestyle-Driven Variations in Nutrimiromic MicroRNA Expression Patterns across and beyond Genders

The importance of diet and lifestyle in maintaining overall health has long been recognised. MicroRNAs (miRNAs) have emerged as key players in the intricate interplay between health and disease. This study, including 305 participants, examined the role of miRNAs from capillary blood as indicators of individual physiological characteristics, diet, and lifestyle influences. Key findings include specific miRNAs associated with inflammatory processes and dietary patterns. Notably, miR-155 was associated with subjects with metabolic diseases and upregulated in age. Additionally, the study revealed diet-related miRNA expressions: high consumption of vegetables, fruits, and whole grains correlated with increased levels of miR-let-7a and miR-328, both implicated in anti-inflammatory pathways, and decreased expression of pro-inflammatory miR-21.

Activated neutrophils are a hallmark of acute lung injury

Here, Dolly Mehta & team find loss of ERG in endothelial cells alters neutrophil transcriptome towards inflammatory lineage via IL8/CXCR2 and CXCR2 blockade with Reparixin reduces inflammation, neutrophil infiltration, and improves survival in a pneumonia model.

The figure shows mouse lungs 30 minutes after antibody administration, with increased number of neutrophils (green) in Erg-null mice compared with Ergfl/fl mice. Endothelium (red).


1Department of Pharmacology and Regenerative Medicine, and.

2Division of Pulmonary, Critical Care, Sleep and Allergy, University of Illinois Chicago, College of Medicine, Chicago, Illinois, USA.

Address correspondence to: Dolly Mehta, Department of Pharmacology and Regenerative Medicine, University of Illinois, Chicago, College of Medicine, 835 S. Wolcott Avenue, Chicago, Illinois 60,612, USA. Phone: 312.355.0236; Email: [email protected].

Immune system uses a conveyor belt-like process to edit defective antibodies, new research finds

The immune system’s B cells create antibodies that can mount a response against just about anything—either destroying a pathogen or instructing the rest of the immune system to go after the offender. But what happens when these antibodies malfunction?

Researchers at Boston Children’s Hospital have identified the previously unknown mechanism for how immune cells can go back and self-edit the genes that code for these antibodies, essentially recycling them into newer versions.

The workings of this new mechanism, published in Nature, were uncovered in the laboratory of Frederick Alt, Ph.D., of the Program in Cellular and Molecular Medicine at Boston Children’s and a Howard Hughes Medical Center Investigator.

CRISPR Technology: Transforming the Future of Medicine and Diagnostics

Among the many promising possibilities of using CRISPR-based therapeutics, their translational use in monogenic human genetic diseases has the potential to provide long-term therapy after a single treatment. Genetic disorders can be treated with the help of CRISPR by editing the defective (disease-causing) gene or by editing the enhancer or regulator of the defective gene. Numerous studies, which are summarized in the table below (Table ), have shown promising results by using these two approaches.

3. Examples of CRISPR-Based Therapeuticsfor the Treatment of Genetic Disorders.

DiseaseCRISPR targetapproachmajor outcome of the studyreferenceDuchenne muscular dystrophydystrophin gene (DMD)single or multiplexed sgRNAs were developedto restore thedystrophin reading frame by targeting the mutational hotspot at exons45–55 and introducing shifts within exons or deleting one ormore exonsdystrophin expression is restored in vitroOusterout et al. Huntington’sdiseaseHuntingtin gene (HTT)HTT 5′ UTR was targetedimpropermaturation of the transcript and reducing the expressionof the disease-causing alleleKolli et al.a dual sgRNA approachwas used in vitro toexcise a 44kb promoter region upstream of a mutant HTT gene to silence its expressionexpression of the Huntington’sdisease-causing variant wasablatedShin et al.glaucomamyocilin gene (MYOC)Knocked down the expression of mutant MYOC in a mouse model of primary open-angle glaucomareductionof ER stress, lower intraocular pressure, and thepreventability of further glaucomatous damage in mouse eyes was observed. The authors also demonstrated the feasibility of utilizing CRISPR/Cas9in human eyes with glaucomaJain et al.hereditary tyrosinemiatype Ifumarylacetoacetate hydrolase gene (FAH)HDR-mediated point mutation correction in mouse hepatocytes.a significant proportion of alleles were correctedVanLith et al. Leber congenital amaurosis type 10 (LCA10)centrosomalprotein 290 gene (CEP290)AAV5-basedtherapy (EDIT-101) encapsulates Staphylococcusaureus Cas9 (SaCas9) and two sgRNAs targeting genomic locationsupstream and downstream of the intronic CEP290 pointmutation. The two sgRNAs enable cutting around the mutation to induceits removal or inversionnormal splicing of CEP290 pre-mRNA was restoredMaeder et al. Noonan syndromeleucine zipper like post translational regulator 1 gene (LZTR1)intron 16 of LZTR1 was targetedthe gene editing process could overcomethe disease phenotypeassociated with Noonan syndrome-associated cardiomyopathy in iPSC-derivedcardiomyocytes in vitroHanses et al. Angelman syndromeUBE3A-ATS Inc. RNAUBE3A-ATS Inc. RNA was targetedin cultured human neurons andin a mouse model of the diseasetargeting of UBE3A-ATSablated its function, leading to expressionof the paternal UBE3A gene and rescuing the diseasephenotypeWolter et al.congenital muscular dystrophy type 1A (MDC1A)laminin subunit alpha 1 gene (LAMA1)CRISPR activator mediated gene upregulation3.6-foldupregulation of LAMA1 was observedKemaladevi et al.genetic deafnesstransmembrane channel like 1gene (TMC1)non-homologous end joining(NHEJ)-mediated mutant Tmc alleledisruptiondeafness was prevented in mouse models upto one year postinjectionGyörgy et al.

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