A subtle shift in how materials are engineered may be redefining the future of superconductivity.
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Navia discloses data breach impacting 2.7 million people
Navia Benefit Solutions, Inc. (Navia) is informing nearly 2.7 million individuals of a data breach that exposed their sensitive information to attackers.
An investigation into the incident revealed that the hackers had access to the organization’s systems between December 22, 2025, and January 15, 2026. However, the company discovered the suspicious activity on January 23.
Navia says that it responded immediately and launched an inquiry to determine the potential impact of the incident.
New ‘PolyShell’ flaw allows unauthenticated RCE on Magento e-stores
A newly disclosed vulnerability dubbed ‘PolyShell’ affects all Magento Open Source and Adobe Commerce stable version 2 installations, allowing unauthenticated code execution and account takeover.
There are no signs of the issue being actively exploited in the wild, but eCommerce security company Sansec warns that “the exploit method is circulating already” and expects automated attacks to start soon.
Adobe has released a fix, but it is only available in the second alpha release for version 2.4.9, leaving production versions vulnerable. Sansec says that Adobe offers a “sample web server configuration that would largely limit the fallout,” but most stores rely on a setup from their hosting provider.
Using mRNA to Fight Tau Aggregation in Alzheimer’s
Researchers publishing in Cell Reports Medicine have described the development of a lipid nanoparticle (LNP) that delivers mRNA to neurons in order to stop the formation of tau aggregates and fight Alzheimer’s disease.
Tau and amyloids
Amyloid beta deposition between neurons and tau aggregation within neurons are both hallmarks of Alzheimer’s disease, and evidence suggests that the latter is potentially more significant than the former [1]. While some potential therapies have been discovered that may disaggregate these tau tangles after they have formed [2], no therapy has yet been approved by the FDA to do this.
How ageing promotes metastasis
The study shows how aging alters the biology of lung cancer and makes tumors more prone to spreading. The researchers identified a molecular signaling pathway, a complex chain of reactions and interactions, in which a specific stress-response protein, ATF4, plays a central role.
Under normal physiological conditions, ATF4 acts as a hub for the “integrated stress response” that responds to events such as nutrient deprivation, viral particles, or the accumulation of misfolded proteins, activating protective and corrective responses, explains the author.
“In older patients, this stress response is hijacked by the tumor, allowing cancer cells to reprogram their metabolism. The tumor does not grow faster, but this metabolic rewiring enables the cancer cells to spread and form metastases in other parts of the body,” the author says.
Tumors from older individuals in the study, both mice and humans, showed higher levels of ATF4. High ATF4 levels were also associated with increased recurrence after lung surgery and poorer survival among patients with lung adenocarcinoma, the most common form of lung cancer.
“Our results suggest that ATF4 is not only part of the mechanism behind the spread of lung cancer but may also serve as a marker of more aggressive disease,” says another author.
The study opens the door to a treatment strategy targeting the age-related signaling system that the tumor has hijacked. By blocking ATF4, or a specific metabolic process controlled by ATF4, with drugs, the researchers were able to dramatically reduce the spread of old tumors in mice.
Previously, it has been unclear why studies using similar drugs have largely failed when tested in humans. The new findings suggest that these treatments may need to be targeted more precisely to the right patient groups. ScienceMission sciencenewshighlights.