University of Florida neuroscientists have made a mechanistic discovery that paves the way to test immune-modulating medicines as a potential tool to break the cycle of methamphetamine addiction.
In a new preclinical study, a McKnight Brain Institute team led by Habibeh Khoshbouei, Ph.D., Pharm. D., examined the role of neuroinflammation in meth addiction to provide a deeper understanding of the mechanisms at work.
“Unlike alcohol or opioids, there currently is no medicinal therapeutic approach for methamphetamine addiction,” said Khoshbouei, a professor of neuroscience and psychiatry. “So this is an important societal issue.”
Scientists at Pacific Northwest Research Institute (PNRI) have overturned a long-held belief in genetics: that inheriting two harmful variants of the same gene always worsens disease. Instead, the team found that in many cases, two harmful variants can actually restore normal protein function.
Their work appears in the Proceedings of the National Academy of Sciences.
Parkinson’s disease (PD) is a debilitating and progressive neurodegenerative disorder caused by the loss of dopamine-producing neurons in the substantia nigra, a brain region essential for motor control. Clinically, it is marked by tremor, rigidity, bradykinesia and postural instability, symptoms that progressively erode independence and quality of life.
PD affects millions of people worldwide, including nearly one million individuals in the United States, making it one of the fastest-growing neurological disorders. In the U.S. alone, the disease imposes a profound health care and socioeconomic burden, with annual costs reaching tens of billions of dollars due to medical care, lost productivity and long-term disability.
While environmental factors contribute to disease risk, genetic drivers are increasingly recognized, with mutations in the leucine-rich repeat kinase 2 (LRRK2) gene representing one of the most common causes of both familial and sporadic PD. Understanding how LRRK2 mutations drive disease is therefore central to developing therapies that go beyond symptoms control.
A new study from Karolinska Institutet, published in Nature Communications, reveals how rhythmic brain waves known as alpha oscillations help us distinguish between our own body and the external world. The findings offer new insights into how the brain integrates sensory signals to create a coherent sense of bodily self.
What makes you feel that your hand is yours? It might seem obvious, but the brain’s ability to tell self from non-self is a complex process.
Using a combination of behavioral experiments, brain recordings (EEG), brain stimulation, and computational modeling with a total of 106 participants, researchers from Karolinska Institutet investigated how the brain combines visual and tactile signals to create the feeling that a body part belongs to oneself—a phenomenon known as the sense of body ownership.
As we age, we don’t recover from injury or illness like we did when we were young. But new research from UCSF has found gene regulators—proteins that turn genes on and off—that could restore the aging body’s ability to self-repair.
The scientists looked at fibroblasts, which build the scaffolding between cells that give shape and structure to our organs.
Fibroblasts maintain this scaffolding in the face of normal wear, disease, and injury. But over time, they slow down, and the body suffers.
Huang made his feelings about AI skeptics, haters, and doom-mongers clear on a recent episode of the No Priors podcast.
The boss of the world’s most valuable company said “the battle of the narratives” between those who think AI will benefit society and those who believe it will degrade or even destroy it was one of his biggest takeaways from 2025.
Huang did admit that “it’s too simplistic” to dismiss either of these views entirely, but he believes some naysayers’ views are having a detrimental effect.
This video explores aliens, mind uploading to other species, genetic engineering, and future robots.
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💡 Future Business Tech explores the future of technology and the world.
Examples of topics I cover include:
• Artificial Intelligence & Robotics.
• Virtual and Augmented Reality.
• Brain-Computer Interfaces.
• Transhumanism.
• Genetic Engineering.
SUBSCRIBE: https://bit.ly/3geLDGO
This video explores the future of ChatGPT and 10 ways it could change society. Other related terms: aliens, alien species, advanced civilization, genetic engineering, robot, mind upload, mind uploading, brain computer interface, artificial intelligence, ai, future business tech, future technology, future technologies, etc.